GC, GC vitamin D binding protein, 2638

N. diseases: 219; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 Biomarker disease BEFREE The concentrations of free Gc-globulin in plasma collected from patients diagnosed with AD (509.6 ±87.6 mg/L) and ALS (455.5 ±99.8 mg/L) did not differ significantly between each other, but were significantly higher compared to the reference group (311.7 ±87.5 mg/L) (p < 0.001 and p < 0.006, respectively) as well as to MS (310.8 ±66.6 mg/L) (p < 0.001 and p < 0.001, respectively) and TBE (256.7 ±76 mg/L) (p < 0.001 and p < 0.003, respectively). 29905407 2018
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 Biomarker disease BEFREE Vitamin D-binding protein and multiple sclerosis: Evidence, controversies, and needs. 30113253 2018
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 GeneticVariation disease BEFREE Vitamin D-Binding Protein Polymorphisms, 25-Hydroxyvitamin D, Sunshine and Multiple Sclerosis. 29414925 2018
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 Biomarker disease BEFREE CF = cystic fibrosis DBP = vitamin D binding protein ELISA = enzyme-linked immunosorbent assay ESLD = end-stage liver disease HC = hormone contraceptives iPTH = intact parathyroid hormone LC-MS = liquid chromatography-mass spectrometry MS = multiple sclerosis 25(OH)D = 25-hydroxyvitamin D PHPT = primary hyperparathyroidism RIA = radioimmunoassay. 28095044 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 GeneticVariation disease BEFREE In conclusion, our findings do not support a role of an independent effect of the investigated vitamin D-related gene variants, VDBP and CYP27B1, in the risk of MS. 27904983 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 Biomarker disease CTD_human Increased circulating levels of vitamin D binding protein in MS patients. 25590278 2015
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 Biomarker disease BEFREE The emerging role of vitamin D binding protein in multiple sclerosis. 21042807 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 GeneticVariation disease BEFREE We found no clear association between MS and frequencies of phenotypes or alleles of Gc protein. 3218452 1988
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.350 Biomarker disease BEFREE Two proteins, namely serum amyloid A4 and vitamin D binding protein, showed high performance in distinguishing patients with rheumatoid arthritis from healthy controls. 31491989 2019
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.350 AlteredExpression disease BEFREE VDBP levels were not significantly different between the races and did not significantly correlate with BMD, 25(OH)D overall, or DAS28 in RA patients. 28217867 2018
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.350 Biomarker disease BEFREE SAA4, gelsolin, and vitamin D-binding protein were validated as potential biomarkers of RA for screening and drug efficacy monitoring of RA. 30662913 2018
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.350 GeneticVariation disease BEFREE The proteomic approach detected significantly decreased expression of vitamin D-binding protein (VDBP) in the synovial membranes from patients with RA, which was confirmed with western blot analysis. rs2282679 was significantly associated with RA and AS (p=0.026794 and 0.007566, respectively). 22704802 2012
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.350 Biomarker disease BEFREE A possible physiological basis between the association of vitamin D binding protein and rheumatoid arthritis is discussed. 3874814 1985
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.350 Biomarker disease CTD_human Gc (vitamin D binding protein) subtypes in rheumatoid arthritis. 3874814 1985
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.330 GeneticVariation disease BEFREE In a retrospective analysis of the double-blind trial of intravenous N-acetylcysteine (NAC) for ALF not because of acetaminophen, sera on days 1 and 3 or days 2 and 4 following admission were available to measure AFP in 70 patients and Gc in 66 patients. 31421008 2019
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.330 AlteredExpression disease LHGDN We measured actin-free Gc globulin levels with a novel, rapid assay in 61 cases of acute liver failure (ALF) and in 91 patients with cirrhosis (40 of whom were clinically unstable with extrahepatic organ dysfunction), and studied associations with liver dysfunction, extrahepatic organ dysfunction, indices of disseminated coagulation, and outcome. 17763400 2007
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.330 AlteredExpression disease LHGDN Predicting outcome in acute liver failure: are we there yet? 17763397 2007
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.330 Biomarker disease CTD_human Furthermore, low levels of Gc globulin in patients with fulminant hepatic failure and multiple trauma have been found to correlate with the morbidity and mortality of patients. 17852808 2007
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.330 Biomarker disease CTD_human In 77 patients with fulminant hepatic failure (FHF) (excluding patients treated with liver transplantation), admission levels of serum Gc-globulin and degree of complexing with monomeric actin (complex ratio) were determined to evaluate their predictive values in relation to survival/nonsurvival. 8666322 1996
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.320 AlteredExpression disease BEFREE The results show that vitamin D status and VDBP levels are associated with liver cirrhosis severity and patients' mortality, possibly through a proinflammatory immune response. 31789949 2019
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.320 Biomarker disease BEFREE Compared with controls, patients diagnosed with LC had significantly lower VDBP and total 25(OH)D concentrations (all <i>P</i> < 0.001) while pregnant women had significantly higher VDBP concentrations (<i>P</i> < 0.001). 30774661 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease CTD_human Effects of olanzapine on serum protein phosphorylation patterns in patients with schizophrenia. 25821032 2015
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.320 GeneticVariation disease BEFREE In conclusion, genetic differences in the VDR gene may be involved in the development of AITD and the activity of GD, whereas the genetic differences in the GC and CYP2R1 genes may be involved with the intractability of GD. 25046415 2014
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.320 Biomarker disease CTD_human Chronic CCl4 intoxication causes liver and bone damage similar to the human pathology of hepatic osteodystrophy: a mouse model to analyse the liver-bone axis. 24381012 2014
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.320 GeneticVariation disease BEFREE A polymorphism within the vitamin D-binding protein gene is associated with Graves' disease but not with Hashimoto's thyroiditis. 12050214 2002