|
Polyendocrinopathies, Autoimmune
|
0.010 |
AlteredExpression
|
group |
BEFREE |
APS significantly reduced the index of the liver and spleen as well as the ALT and AST levels in serum (P < 0.05).
|
31220694 |
2019 |
|
Alcohol abuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
In alcoholics, compared to the controls, we found: a significant increase in serum: AST (p = 0.0014), ALT (p = 0.0071), AST/ALT ratio (p < 0.000); significantly lower plasma free carnitine (FC) (p = 0.0316) and total carnitine (TC) (p = 0.0349); and a significant negative correlation between FC (r = -0.6200; R<sup>2</sup> = 0.3844; p = 0.0007), TC (r = -0.4365; R<sup>2</sup> = 0.1905; p = 0.0258), and time of alcohol dependence, suggesting carnitine as an indirect marker of alcohol abuse.
|
31029632 |
2019 |
|
Allergic asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The overall results confirmed that AST with TWDS prescription had a significant protective effect against OVA-induced allergic asthma in guinea pig.
|
30668368 |
2019 |
|
HELLP Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
We concluded that the APRI score was robustly predicted HELLP syndrome than AST alone in this study.
|
30777375 |
2019 |
|
Malignant ascites
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Hence, in this study, the efficacy and toxicity of KPC and KA on normal rats and MA rats were firstly evaluated by serum liver enzymes (ALT and AST), oxidative damage indicators (GSH, SOD, MDA and LDH), inflammatory indexes (TNF-α, IFN-γ and IL-2) and the volume of ascites.
|
30947126 |
2019 |
|
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
<b>Results</b>: Our findings revealed that Eth pretreatment significantly improved the IA memory impairment induced by PTZ (<i>P</i> < 0.001), and indicated no change in locomotion and serum ALT, but significantly differed for AST between the PTZ and PTZ groups (<i>P</i> = < 0.05).
|
30967097 |
2019 |
|
Cholestasis of pregnancy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Likewise, laboratory parameters such as transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) and total bilirubin levels were significantly higher in the ICP group (<i>p</i> < 0.005).There were no statistically significant differences in the fetal complications.
|
31430816 |
2019 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
With regard to the antitumor activity of Co-SLD, inhibited cell growth and migration capability were outstandingly observed in oral squamous cell carcinoma treated with 10 and 20 μM Co-SLD, which could be mainly attributed to the Co-SLD-elicited mitochondrial damage as marked by the depression of mitochondrial membrane potential, ROS accumulation and ATP depletion.
|
31062618 |
2019 |
|
Obstruction of biliary tree
|
0.010 |
Biomarker
|
disease |
BEFREE |
Regarding biochemical parameters, the exposure to the test mixture caused non-monotonic increases of AST and ALT, a decrease of PChE in males and plausibly a monotonic biliary obstruction in both sexes.
|
30999039 |
2019 |
|
Forgetful
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
<b>Results</b>: Our findings revealed that Eth pretreatment significantly improved the IA memory impairment induced by PTZ (<i>P</i> < 0.001), and indicated no change in locomotion and serum ALT, but significantly differed for AST between the PTZ and PTZ groups (<i>P</i> = < 0.05).
|
30967097 |
2019 |
|
Auricular swelling
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Despite the transient ear swelling and local cell infiltration, no alterations in AST, ALT and creatinine serum levels was induced by d-AmB/PLGA.
|
31331828 |
2019 |
|
Dissection of proximal aorta
|
0.010 |
Biomarker
|
disease |
BEFREE |
In multivariable analysis, APACHE II score [Score 21-25: HR =9.5 (1.2-74.4), P=0.032; Score >25: HR =51.0 (6.7-387.7), P=0.0001], AST >80 µmol/L [HR =2.3 (1.1-4.8), P=0.0251], aortic cross-clamping time >120 min (HR =2.9 (1.1-7.7), P=0.0315) remained significant in predicting TAAD in-hospital mortality.
|
31656662 |
2019 |
|
Diabetic peripheral neuropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
ALB = albumin; ALT = alanine transaminase; AST = aspartate transaminase; AUC = area under the curve; AUCc-p/AUCglu = AUC of C-peptide/AUC of glucose; BMI = body mass index; BP = blood pressure; CI = confidence interval; Cr = creatinine; DBP = diastolic blood pressure; DPN = diabetic peripheral neuropathy; FC-P = fasting C-peptide; FPG = fasting plasma glucose; FFA = free fatty acid; γ-GGT = γ-glutamyl transferase; HbA1c = glycated hemoglobin A1c; HDL-C = high-density-lipoprotein cholesterol; ISI = insulin sensitivity index; ISSI-2 = insulin secretion-sensitivity index-2; LDL-C = low-density-lipoprotein cholesterol; MNCS = motor nerve conduction velocity; OGTT = oral glucose tolerance test; PG = plasma glucose; SAT = subcutaneous adipose tissue; SBP = systolic blood pressure; SNCS = sensory nerve conduction velocity; T2DM = type 2 diabetes mellitus; TC = total cholesterol; TG = triglyceride; UA = uric acid; VAT = visceral adipose tissue; WC = waist circumference.
|
30913011 |
2019 |
|
Abdominal Infection
|
0.010 |
Biomarker
|
group |
BEFREE |
This new guideline from the AST IDCOP reviews intra-abdominal infections (IAIs), which cause substantial morbidity and mortality among abdominal SOT recipients.
|
31102546 |
2019 |
|
Renal Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
The addition of AST-120 to conventional treatments may delay the progression of renal dysfunction in diabetic nephropathy.
|
31001934 |
2019 |
|
CATARACT, ANTERIOR POLAR
|
0.010 |
Biomarker
|
disease |
BEFREE |
Low leukocytes count and high AST values were also significantly associated with H1N1 CAP.
|
31007805 |
2019 |
|
Tumour rupture
|
0.010 |
Biomarker
|
disease |
BEFREE |
Grade 4 adverse events (according to the Common Terminology Criteria for Adverse Event version 4.0) of AST, ALT and tumor rupture were found in 8, 4 and 1 patients, respectively.There were no treatment-related deaths.
|
31338551 |
2019 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Leukocytes, glucose, aspartate aminotransferase (AST (SGOT)), alanine aminotransferase (ALT (SGPT)), alkaline phosphatase (ALP), total and direct bilirubin levels were significantly higher in the AP group (<i>p</i> < 0.05, all).
|
29593801 |
2018 |
|
Esophageal Varices
|
0.010 |
Biomarker
|
disease |
BEFREE |
Univariate analysis of patients taking β-blockers showed an association of PVT with grade of esophageal varices (p < 0.01), CP class (p < 0.02), AST (p < 0.03), ALT and albumin (p < 0.02), PLT count and PLT/LD (p < 0.03), longitudinal diameter of the spleen (p < 0.005), ascites (p < 0.05), portal vein (p < 0.0001) and NSBB (OR 8.1; 95% CI 1.7-38.8).
|
30107378 |
2018 |
|
Fascioliasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Symptom onset one month before egg detection and normal levels of ALT and AST did not agree with the 3-4-month migratory period of fascioliasis.
|
29975653 |
2018 |
|
Hypergammaglobulinemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Also, the serum levels of IL-17A and IL-22 were correlated positively with liver injury (ALT/AST), whereas the serum levels of IL-10 were correlated negatively with hypergammaglobulinaemia (IgG, IgM) in AIH patients.
|
30050955 |
2018 |
|
Lassa Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
Quantitative PCR to detect Lassa RNA, and clinical chemistry to detect high liver enzymes (AST/ALT) are commonly used to diagnose Lassa fever.
|
28986826 |
2018 |
|
Liver neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In nanoDEN-induced HCC mice treated with LSW-ET by oral (po) or intragastric gavage (ig), we observed an alleviation of serum ALT and AST levels, amelioration in histopathological stainings, and an inhibition in liver tumor growth.
|
30356380 |
2018 |
|
Liver Failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
COP ameliorated the LPS/D-GalN-induced liver failure by lowering serum levels of ALT and AST, raising hepatic GSH and SOD levels, and maintaining the morphology of hepatocytes, along with an increase in miR-122 expression in mice.
|
29253766 |
2018 |
|
Hypogammaglobulinemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Hypogammaglobulinemia and imaging features in a patient with infantile free sialic acid storage disease (ISSD) and a novel mutation in the SLC17A5 gene.
|
30243016 |
2018 |