|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
This study detected the clinical significance of DKK4 in epithelial ovarian cancer (EOC) patients and its role in invasion.
|
28666421 |
2017 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
DKK4-knockdown promoted inhibition of A549/DTX cell growth, and reduced the colony formation and invasion capacity of A549/DTX cells.
|
28981599 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
Biomarker
|
disease |
BEFREE |
Dickkopf-related protein 4 (DKK4) is a target of the β-catenin/transcription factor 4 complex in colorectal cancer.
|
28356933 |
2017 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
In function assays, stable DKK4 transfected into J7 or HepG2 cells decreased cell invasion in vitro.
|
21994129 |
2012 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Colorectal-cancer cell lines overexpressing DKK4 showed increased chemoresistance to fluorouracil but not irinotecan or oxaliplatin.
|
22216841 |
2012 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
Biomarker
|
disease |
BEFREE |
Like Dickkopf-1 (DKK1), DKK4 is a target of beta-catenin/Tcf-4 in colorectal cancer.
|
19059704 |
2009 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
DICKKOPF-4 and -2 genes are upregulated in human colorectal cancer.
|
19659606 |
2009 |
|
Tumor Cell Invasion
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Ectopic DKK-4 expression increased the migration and invasion properties of colon cancer cells and conditioned media (CM) from DKK-4-expressing cells enhanced the capacity to migrate and form capillary-like tubules of human primary microvascular endothelial cells.
|
18408752 |
2008 |
|
Tumor Cell Invasion
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Unexpectedly, DKK-4 is a target of the Wnt/beta-catenin pathway and is up-regulated in colorectal tumours, and it has been shown to increase cell migration and invasion and to promote a proangiogenic phenotype.
|
19035286 |
2008 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Aberrant accumulation of Dickkopf 4 promotes tumor progression via forming the immune suppressive microenvironment in gastrointestinal stromal tumor.
|
31353847 |
2019 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Role of DKK4 in Tumorigenesis and Tumor Progression.
|
29904276 |
2018 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
A more distinct comprehension about the effect of DKK4 on tumorigenesis and tumor process will shed light on biomedical research of DKK4 and tumor research.
|
29904276 |
2018 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
We demonstrate that activation of SHP (Small Heterodimer Partner), DKK4 (Dickkopf-4), and CADM4 (Cell Adhesion Molecule 4) by SRC-2 suppresses tumorigenesis in vitro and in vivo.
|
28273073 |
2017 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Here we report a novel mechanism by which secreted plasma glutamate carboxypeptidase(PGCP) negatively involves Wnt/β-catenin signaling by DKK4 regulation in liver cancer metastasis.
|
27806330 |
2016 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our in vitro and in vivo results indicate an important functional role of DKK4 in glucose facilitated HCC proliferation.
|
27272409 |
2016 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Metastases have higher DKK4 and NOTCH signaling levels and are more chemoresistant than paired subcutaneous xenografts.
|
26006007 |
2015 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
By activating other pathways apart from the Wnt/β-catenin pathway, DKK4 may play an important role in ccRCC tumorigenesis and metastasis.
|
24573574 |
2014 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
By activating other pathways apart from the Wnt/β-catenin pathway, DKK4 may play an important role in ccRCC tumorigenesis and metastasis.
|
24573574 |
2014 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
J7-DKK4 and J7-TRα1 overexpressing mice, which displayed growth arrest, lower lung colony formation index, and smaller tumor size than in control mice, supporting an inhibitory role of DKK4 in tumor progression.
|
21994129 |
2012 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
DKK4 was down-regulated in 67.5% of HCC cancerous tissues.
|
21994129 |
2012 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
To study the effect of DKK4 on cell growth and tumourigenicity, two stable HCC cell lines were established from PLC and 97L cells.
|
22249261 |
2012 |
|
Gastrointestinal Stromal Tumors
|
0.020 |
Biomarker
|
group |
BEFREE |
Our findings identified DKK4 as a proper tumor biomarker for prognosis predicting and recurrence monitoring, and suggested a novel immune-escape mechanism driving malignancy in GIST, which might be a potential therapeutic target to improve the effects of canonical RTK therapy and combined immunotherapy.
|
31353847 |
2019 |
|
Malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Survival tree analysis depicted DKK4 rs2073664 as the major contributor in predicting the survival of the lung cancer patients.
|
30346805 |
2018 |
|
Carcinoma of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Survival tree analysis depicted DKK4 rs2073664 as the major contributor in predicting the survival of the lung cancer patients.
|
30346805 |
2018 |
|
Primary malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Survival tree analysis depicted DKK4 rs2073664 as the major contributor in predicting the survival of the lung cancer patients.
|
30346805 |
2018 |