|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results suggest that high AMY1 gene copy number protects against obesity in Portuguese young adults.
|
30200782 |
2018 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Copy number variation (CNV) of AMY1 has been implicated in human dietary adaptation, and in population association with obesity, but neither of these findings has been independently replicated.
|
28101908 |
2017 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The OR value of 1.19 per copy of AMY1 translates into about an eightfold difference in risk of obesity between subjects in the top (copy number > 9) and bottom (copy number < 4) 10% of the copy number distribution.
|
24686848 |
2014 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Yet, we also found a significant negative contribution of AMY1 activity at baseline to the change in BMI during the 9-year follow-up, and a significant contribution of AMY1A copy number to lower obesity risk in children, suggesting a bidirectional relationship between AMY1 activity and adiposity.
|
28228143 |
2017 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Obesity, starch digestion and amylase: association between copy number variants at human salivary (AMY1) and pancreatic (AMY2) amylase genes.
|
25788522 |
2015 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The global association between AMY1 copy number and reduced risk of obesity seemed to be mostly driven by the contribution of the highest AMY1 copy number.
|
25394825 |
2015 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
(Cell Host Microbe 2019;25;553-564.E7) reported that AMY1 copy number, associated with obesity, also impacts microbiome composition and function.
|
31056302 |
2019 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Low Copy Number of the AMY1 Locus Is Associated with Early-Onset Female Obesity in Finland.
|
26132294 |
2015 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
To further our understanding of this relationship, we: 1) examined the role of priming on physiological measures (e.g. salivary alpha amylase and skin conductance) in 70 college students by introducing positive and negative media images of individuals with obesity, and 2) assessed psychological measures (e.g. perceived stress, need to belong, and self-esteem, and Body Mass Index).
|
29084240 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In two further case-control cohorts (n = 932 and 145, for Chinese and Malays, respectively), we did not observe the previously reported association between AMY1 and obesity or body mass index.
|
27068483 |
2016 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Copy number of AMY1 is reported to be the largest genomic influence on obesity, although genome-wide association studies for obesity have found this locus unremarkable.
|
26098870 |
2015 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently studies have shown that the copy number of AMY1 is associated with obesity; however, the data varies with location.
|
31248128 |
2019 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, the highly polymorphic CNV in the salivary amylase (AMY1) gene, encoding an enzyme implicated in the first step of starch digestion, has been associated with obesity in adults and children.
|
27149670 |
2016 |
|
Anxiety
|
0.050 |
Biomarker
|
disease |
BEFREE |
The change of sAA after stroop test in GAD patients can predict the severity of anxiety, but subjective psychological perception can not.
|
31726179 |
2020 |
|
Anxiety
|
0.050 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> Salivary α-amylase (sAA), galvanic skin response (GSR) and anxiety were assessed over a 2-h operating flight.
|
29867525 |
2018 |
|
Anxiety
|
0.050 |
Biomarker
|
disease |
BEFREE |
We examined physiological stress responses (cortisol and salivary alpha-amylase [sAA]), negative emotional stress responses (anxiety and self-conscious emotions), and post-task ruminative thoughts.
|
31497984 |
2019 |
|
Anxiety
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The following outcomes will be recorded: completion of dental treatment, anxiety scores at baseline and after treatment using Frankl rating behavior scale and physiological anxiety related changes will be recorded using salivary Alpha Amylase and Cortisol levels.
|
31464945 |
2019 |
|
Anxiety
|
0.050 |
Biomarker
|
disease |
BEFREE |
We examined physiological stress responses (cortisol and salivary alpha-amylase [sAA]), negative emotional stress responses (anxiety and self-conscious emotions), and post-task ruminative thoughts.
|
30265076 |
2019 |
|
Mental Depression
|
0.020 |
Biomarker
|
disease |
BEFREE |
Child depression has been inconsistency linked to cortisol and salivary alpha-amylase (sAA) reactivity.
|
31707039 |
2020 |
|
Mental Depression
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Elevated salivary alpha-amylase levels at awakening in patients with depression.
|
30005283 |
2018 |
|
Depressive disorder
|
0.020 |
Biomarker
|
disease |
BEFREE |
Child depression has been inconsistency linked to cortisol and salivary alpha-amylase (sAA) reactivity.
|
31707039 |
2020 |
|
Depressive disorder
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Elevated salivary alpha-amylase levels at awakening in patients with depression.
|
30005283 |
2018 |
|
Stress, Psychological
|
0.020 |
Biomarker
|
disease |
BEFREE |
Moreover, the basic function of sympathetic-adrenal medulla system was hyperfunctional in GAD patients while theirs reactivity was limited, which showed the more serious the lesion was, the higher the baseline value of sAA was, and the less sAA secretion increase would be, or even decrease after mental stress.
|
31726179 |
2020 |
|
Stress, Psychological
|
0.020 |
Biomarker
|
disease |
BEFREE |
For this purpose, six healthy women with a similar body mass index, age, and fit, underwent different sAA stimulation tests, such as acetic acid stimulation, psychological stress using the standardized Trier social stress test, and physical effort using the Cooper treadmill test.
|
31388762 |
2020 |
|
Malnutrition
|
0.020 |
Biomarker
|
disease |
BEFREE |
Unchanged sAA indicates a partial adaptation of human organism to severe condition during malnutrition.
|
30880537 |
2019 |