|
Epidermodysplasia Verruciformis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
As the receptor and key signaling of Ang-(1-7), next experiments found that Mas receptor expression and eNOS phosphorylation were decreased in mesenteric arteries from EVs-treated SD rats.
|
31328772 |
2020 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ang-(1-7) treatment attenuated Ang II-induced AAA via inhibiting vascular inflammation, extracellular matrix degradation and SMCs apoptosis.
|
31658493 |
2020 |
|
Salivary Gland Pleomorphic Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ang-1 and Ang-2 significantly enhanced TNF-induced expression of pro-inflammatory cytokines and chemokines in macrophages from healthy donors differentiated with RA and PsA SF and peripheral blood-derived macrophages from RA and PsA patients.
|
31377797 |
2020 |
|
Addison Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In patients suffering from primary AI, RAAS activity was highly increased with elevated concentrations of renin concentration (P = 0.027), angiotensin (Ang) I (P = 0.022), Ang II (P = 0.032), Ang 1-7 and Ang 1-5.
|
31075757 |
2019 |
|
Alveolar Bone Loss
|
0.010 |
Biomarker
|
disease |
BEFREE |
In vivo, Ang-(1-7) and DIZE decreased alveolar bone loss through improvement of osteoblast/osteoclast ratio.A-779 reversed such phenotype.
|
31442676 |
2019 |
|
Fatigue
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Compared with a thermoneutral control intervention, HT improved fatigue resistance of the knee extensors and enhanced the expression of the angiogenic mediators vascular endothelial growth factor and angiopoietin 1.
|
30605396 |
2019 |
|
Gastritis, Atrophic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, the gene expression of Ang-1 and Ang-2 was not significant difference between control rats and CAG rats, and WQD also had no significant effect on the gene expression of Ang-1 and Ang-2.
|
31320912 |
2019 |
|
Hyperglycemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this article, the ability of an engineered angiopoietin-1 variant (COMP-Ang1) to ameliorate the injurious effects of hyperglycemia on barrier integrity in a human retinal microvascular endothelial cell (HRMvEC) model is comprehensively investigated.
|
31415078 |
2019 |
|
Hyperinsulinism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Endometrial VEGFA was significantly decreased after treatment with high insulin in vivo and in vitro (p<0.05), whereas ANG-1 and TIE2 expression was significantly increased (p<0.05).
|
31412315 |
2019 |
|
Hypertension, Renovascular
|
0.010 |
Biomarker
|
disease |
BEFREE |
Very few studies investigated the role of components of the counterregulatory RAS axis (ACE2, Ang-(1-7) and Mas receptor) in renovascular hypertension and the results are controversial.
|
30950337 |
2019 |
|
Muscle Rigidity
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We find that the introduction of Ang1 not only accelerates the recovery of NP-induced endothelial leakiness (NanoEL) but also promotes cell rigidity by increasing tubulin acetylation, thereby remodels the endothelial cells to further mitigate the effects of NP exposure through the activation of the Akt pathway.
|
30776942 |
2019 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Moreover, our previous results suggested that the intrathecal (i.t.) administration of Ang (1-7), an N-terminal fragment of Ang II, may attenuate the Ang II-induced nociceptive behaviour through the inhibition of p38 MAPK phosphorylation via Mas receptors.Here, we investigated whether the i.t. administration of Ang (1-7) can attenuate STZ-induced diabetic neuropathic pain.
|
30421564 |
2019 |
|
Occupational Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Silicosis, caused by inhalation of silica dust, is the most serious occupational disease in China and the aim of present study was to explore the protective effect of Ang (1-7) on silicotic fibrosis and myofibroblast differentiation induced by Ang II.
|
31262387 |
2019 |
|
Oral Submucous Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the effects of Ang-(1-7) on OSF remain unknown.
|
30246378 |
2019 |
|
Systemic Scleroderma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum concentrations of Ang1 were significantly lower [mean (S.D.): 21516.04 (11,441.035) pg/ml], and Ang2 significantly increased [25,89.55 (934.225) pg/ml] in SSc as compared with the control group [Ang1: 28,457.08 (10,431.905) pg/ml; Ang2: 1556.23 (481.255) pg/ml, p < 0.01, respectively], whereas VEGF did not differ significantly.
|
31075243 |
2019 |
|
Silicosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggested that an imbalance between ACE-Ang II-AT1 axis and ACE2-Ang (1-7)-Mas axis may participate in the development of silicosis.
|
31346990 |
2019 |
|
Takayasu Arteritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate serum levels of a panel of angiogenic inducers (VEGF, FGF-2, Angiopoietin 1, -2, soluble VCAM-1) and inhibitors (angiostatin, endostatin, pentraxin-3) in patients with giant cell arteritis (GCA) and Takayasu's arteritis (TAK), in order to gain further insights into the molecular mechanisms driving angiogenesis dysregulation in large-vessel vasculitis (LVV).
|
31573481 |
2019 |
|
Giant Cell Arteritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate serum levels of a panel of angiogenic inducers (VEGF, FGF-2, Angiopoietin 1, -2, soluble VCAM-1) and inhibitors (angiostatin, endostatin, pentraxin-3) in patients with giant cell arteritis (GCA) and Takayasu's arteritis (TAK), in order to gain further insights into the molecular mechanisms driving angiogenesis dysregulation in large-vessel vasculitis (LVV).
|
31573481 |
2019 |
|
Uremia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Peritoneal Ang-1 protein expression and Tie-2 phosphorylation were significantly lower in uremic rats than in control rats and were further significantly reduced in uremia+PD rats.
|
31632561 |
2019 |
|
Addictive Behavior
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
After stimulation of VEGF or bradykinin, the addiction to equimolar amounts of wtANGPT1 and ANGPT1 p.A119S clearly reduced the expression of VE-cadherin on the endothelial cell surface (31% and 24% respectively).
|
30689269 |
2019 |
|
Squamous cell carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of ANGPT1 was significantly down-regulated in patients in lung squamous cell carcinoma and lung adenocarcinoma.
|
31385379 |
2019 |
|
Malignant tumor of peritoneum
|
0.010 |
Biomarker
|
disease |
BEFREE |
We aimed to assess whether trebananib, a peptibody that inhibits binding of angiopoietin 1 and 2 to Tie2, improved progression-free survival when added to carboplatin and paclitaxel as first-line therapy in advanced epithelial ovarian, primary fallopian tube, or peritoneal cancer in a phase 3 clinical trial.
|
31076365 |
2019 |
|
Adrenocortical carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aims of our study were to demonstrate the inhibitory role of Ang 1-7 in A-II-mediated aldosterone production by interacting with the MAS receptor in human adrenocortical carcinoma (HAC15) cells, and clarify the intracellular signaling mechanisms underlying the inhibition of aldosterone production by Ang 1-7.
|
30125658 |
2019 |
|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results show an anti-inflammatory effect of Ang-(1-7), inducing the return of pulmonary homeostasis and attenuation of the behavioral changes in experimental model of PE by elastase.
|
31837773 |
2019 |
|
Congenital posterior urethral valves
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased urinary levels of angiotensin-converting enzyme 2 and of Ang-(1-7) in fetuses with posterior urethral valve could represent a regulatory response to the intense inflammatory process triggered by posterior urethral valve.
|
29534877 |
2019 |