ANGPT1, angiopoietin 1, 284

N. diseases: 340; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.060 Biomarker disease BEFREE 3 weeks post AMI, data showed increase in capillary density (p < 0.01) and reduction in infarct sizes (p < 0.05) in Bac-NP(Ang1) compared to Bac(Ang1), NP(Ang1) and control groups due to enhanced myocardial Ang-1 expression at peri-infarct regions (1.65 times higher than Bac(Ang1)). 21840594 2011
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia 		0.010 Biomarker disease BEFREE BPD is associated with a shift from traditional angiogenic growth factors (vascular endothelial growth factor, angiopoietin-1) to alternative regulators such as endoglin, which may contribute to BPD-associated microvascular dysangiogenesis. 18420967 2008
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.010 Biomarker disease BEFREE BPD is associated with a shift from traditional angiogenic growth factors (vascular endothelial growth factor, angiopoietin-1) to alternative regulators such as endoglin, which may contribute to BPD-associated microvascular dysangiogenesis. 18420967 2008
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.080 Biomarker group BEFREE Diabetes-induced nephrin phosphorylation was also reduced in mice with angiopoietin-1 repletion. 24009238 2014
CUI: C0011847
Disease: Diabetes
Diabetes 		0.060 Biomarker disease BEFREE Diabetes-induced nephrin phosphorylation was also reduced in mice with angiopoietin-1 repletion. 24009238 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 GeneticVariation group BEFREE Hypertension was induced in adult Sprague-Dawley rats by infusion of aldosterone (ALDO; 0.75 μg/hour) for 4 weeks with or without co-treatment of Ang1-7 (1 mg/kg/day).Untreated rats served as controls. 30715105 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 AlteredExpression disease BEFREE Ang1 was then overexpressed in a human breast cancer cell line (MCF-7) on its own and in conjunction with FGF1, an angiogenic factor shown to be able to increase the tumorigenicity of MCF-7 cells. 11027428 2000
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.100 AlteredExpression disease BEFREE Ang1 was then overexpressed in a human breast cancer cell line (MCF-7) on its own and in conjunction with FGF1, an angiogenic factor shown to be able to increase the tumorigenicity of MCF-7 cells. 11027428 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Ang1 expression was found in a few astrocytes scattered in the tumor at all stages of astrocytoma progression. 11304469 2001
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.050 AlteredExpression disease BEFREE Ang1 expression was found in a few astrocytes scattered in the tumor at all stages of astrocytoma progression. 11304469 2001
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.020 AlteredExpression disease BEFREE Ang1 expression was found in a few astrocytes scattered in the tumor at all stages of astrocytoma progression. 11304469 2001
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 AlteredExpression disease BEFREE Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodeling. 11309342 2001
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.100 AlteredExpression disease BEFREE Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodeling. 11309342 2001
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.060 AlteredExpression disease BEFREE Ang-1 was the most highly expressed ligand in late stage RA synovial fibroblasts; however, in chronic inflamed synovial tissue, Ang-2 was predominant and was expressed at strikingly high levels (70 to 120-fold increase). 11838839 2002
CUI: C0003864
Disease: Arthritis
Arthritis 		0.040 Biomarker disease BEFREE Ang-1 may therefore be an important regulator of angiogenesis in inflammatory arthritis. 12525377 2003
CUI: C0700636
Disease: Focal nodular hyperplasia of liver
Focal nodular hyperplasia of liver 		0.020 Biomarker disease BEFREE Ang-1 protein was detected on Western blot of FNH and expressed by endothelial cells of dystrophic vessels and sinusoids as shown by immunohistochemistry. 12612904 2003
CUI: C0333980
Disease: Focal Nodular Hyperplasia
Focal Nodular Hyperplasia 		0.010 AlteredExpression disease LHGDN Ang-1 protein was detected on Western blot of FNH and expressed by endothelial cells of dystrophic vessels and sinusoids as shown by immunohistochemistry. 12612904 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 AlteredExpression disease BEFREE Ang-1 was expressed in 68% of HCCs, whereas Ang-2 was expressed in 81%, and was significantly higher in poorly differentiated HCCs characterised by high vascularity (p = 0.02), and in tumours with a peliotic change (p = 0.02). 14600132 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 Biomarker disease BEFREE Angiopoietin-1 and -2 cDNA were subcloned into the pcDNA3 vector and subsequently transfected into a human SMMC7721 hepatocellular carcinoma (HCC) cell line without detectable angiopoietin gene expression before transfection. 14607656 2003
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Angiopoietin-1 and Angiopoietin-2 have been shown to be involved in tumor angiogenesis. 15094228 2004
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.030 Biomarker group BEFREE Angiopoietin-1 causes reversible degradation of the portal microcirculation in mice: implications for treatment of liver disease. 15331413 2004
CUI: C0264694
Disease: Chronic myocardial ischemia
Chronic myocardial ischemia 		0.010 Biomarker disease BEFREE Angiopoietin-1 promotes functional neovascularization that relieves ischemia by improving regional reperfusion in a swine chronic myocardial ischemia model. 16547766 2006
CUI: C0008479
Disease: Chondrosarcoma
Chondrosarcoma 		0.010 AlteredExpression disease BEFREE Ang-1 presented as a low-level transcript with slightly elevated levels in chondrosarcomas (P < .05). 16565972 2006
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.030 Biomarker disease BEFREE Ang-1 and Tie2 positivity correlated with advanced gastric cancers (p<0.05) and larger cancers had higher positive rates of Ang-1, Ang-2, and Tie2 mRNA expression (p<0.001, =0.010 and =0.039, respectively). 16614513 2006
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.060 Biomarker disease BEFREE Ang-1 stimulates the ERK/MAPK and PI 3-kinase/Akt pathways cooperatively, but in a manner independent of each other, to directly potentiate synovium overgrowth and joint destruction in RA. 17599743 2007