|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results show an anti-inflammatory effect of Ang-(1-7), inducing the return of pulmonary homeostasis and attenuation of the behavioral changes in experimental model of PE by elastase.
|
31837773 |
2019 |
|
Acute colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
COMP-Ang1 decreases inflammatory-induced lymphangiogenesis in experimental acute colitis.
|
29610929 |
2018 |
|
Acute GVH disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Simvastatin improved the survival of aGVHD mice, attenuated the histopathological GVHD grades and plasma levels of Ang-2, and elevated the plasma levels of Ang-1 as well as the aortic endothelial levels of Ang-1 and Ang-2.
|
28122283 |
2017 |
|
Acute Megakaryocytic Leukemias
|
0.010 |
Biomarker
|
disease |
BEFREE |
The coexpression of Tie-2 and angiopoietin-1 in megakaryoblastic leukaemia cell lines suggests the existence of an autocrine ligand/receptor signalling loop in these cells.
|
9233584 |
1997 |
|
Acute myocardial infarction
|
0.060 |
Biomarker
|
disease |
BEFREE |
3 weeks post AMI, data showed increase in capillary density (p < 0.01) and reduction in infarct sizes (p < 0.05) in Bac-NP(Ang1) compared to Bac(Ang1), NP(Ang1) and control groups due to enhanced myocardial Ang-1 expression at peri-infarct regions (1.65 times higher than Bac(Ang1)).
|
21840594 |
2011 |
|
Acute myocardial infarction
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Compared with IV-UTMD, IC-UTMD can enhance Ang1 plasmid transfection efficiency after MI, promote gene expression and angiogenesis, and improve left ventricular remodeling without decreasing safety.
|
28679128 |
2017 |
|
Acute myocardial infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The intravenous administration of the Ang-1 gene was carried out by UTMD in rabbits with acute myocardial infarction (AMI).
|
26035181 |
2015 |
|
Acute myocardial infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that PF hydrogels can simultaneously provide mechanical support to attenuate adverse myocardial remodelling, and a pro-angiogenic benefit from the sustained VEGF and ANG1 delivery that culminates in a restorative effect following MI.
|
27756647 |
2017 |
|
Acute myocardial infarction
|
0.060 |
Biomarker
|
disease |
BEFREE |
To evaluate this hypothesis, a rat model with acute myocardial infarction and intramyocardially transplanted Ang1-expressing hASCs (hASC-Ang1), genetically modified by Bac-NP(Ang1), was used.
|
22334788 |
2012 |
|
Acute myocardial infarction
|
0.060 |
Biomarker
|
disease |
BEFREE |
Mesenchymal stem cells modified with angiopoietin-1 improve remodeling in a rat model of acute myocardial infarction.
|
17445769 |
2007 |
|
Acute pancreatitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
It was concluded that Ang‑(1‑7) may possess an inhibitory effect on CAE‑induced pancreatic acinar cell apoptosis and that appropriate interventions in RAS may attenuate pancreatic injury during AP.
|
28713987 |
2017 |
|
Acute pancreatitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Angiopoietin-1 gene-modified human mesenchymal stem cells promote angiogenesis and reduce acute pancreatitis in rats.
|
25120736 |
2014 |
|
Acute respiratory distress
|
0.010 |
Biomarker
|
disease |
BEFREE |
The balance between Ang II/AT1R and Ang-(1-7)/Mas plays a pivotal role in the development of lipopolysaccharides (LPS)-induced acute respiratory distress syndrome.
|
30537127 |
2019 |
|
Addictive Behavior
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
After stimulation of VEGF or bradykinin, the addiction to equimolar amounts of wtANGPT1 and ANGPT1 p.A119S clearly reduced the expression of VE-cadherin on the endothelial cell surface (31% and 24% respectively).
|
30689269 |
2019 |
|
Addison Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In patients suffering from primary AI, RAAS activity was highly increased with elevated concentrations of renin concentration (P = 0.027), angiotensin (Ang) I (P = 0.022), Ang II (P = 0.032), Ang 1-7 and Ang 1-5.
|
31075757 |
2019 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Importantly, MVD was lower in Ang-1-expressing adenocarcinoma tissues relative to Ang-1-negative tissues (p < 0.01).
|
17785951 |
2007 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Importantly, MVD was lower in Ang-1-expressing adenocarcinoma tissues relative to Ang-1-negative tissues (p < 0.01).
|
17785951 |
2007 |
|
Adenocarcinoma of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to characterize RAS expression in human colon adenocarcinoma and to investigate whether Ang1-7 exerts an antiproliferative effect on human colon adenocarcinoma cells.
|
22048948 |
2012 |
|
Adenocarcinoma of large intestine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the increased expression of Ang-2 and the decreased expression of Ang-1 may be responsible for blood vessel formation and rapid growth of the colorectal adenocarcinoma.
|
17785951 |
2007 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expression of ANGPT1 was significantly down-regulated in patients in lung squamous cell carcinoma and lung adenocarcinoma.
|
31385379 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Recent studies show that Ang1-7 has an antiproliferative action on lung adenocarcinoma cells.
|
22048948 |
2012 |
|
Adenocarcinoma of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
Microarray data showed that Ang-2 was upregulated in neuroendocrine tumors ( approximately 8 times more than normal) and adenocarcinoma of the pancreas ( approximately 5 times more than normal) although Ang-1 and Tie-2 were not differentially expressed.
|
15501112 |
2004 |
|
Adrenocortical carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aims of our study were to demonstrate the inhibitory role of Ang 1-7 in A-II-mediated aldosterone production by interacting with the MAS receptor in human adrenocortical carcinoma (HAC15) cells, and clarify the intracellular signaling mechanisms underlying the inhibition of aldosterone production by Ang 1-7.
|
30125658 |
2019 |
|
Adult Glioblastoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Using two patient-derived novel primary cell culture models (MTA10 and KW10), we developed a minimal but unique four-gene signature comprising genes vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor B (VEGF-B) and angiopoietin 1 (ANG1), angiopoietin 2 (ANG2) that effectively segregated the proneural (MTA10) and mesenchymal (KW10) glioblastoma subtypes.
|
28744448 |
2017 |
|
Adult Glioblastoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Coculture of glioblastoma cell lines producing Ang1 with endothelium demonstrated a key role of this ligand in the control of EC network organization.
|
11304469 |
2001 |