|
Narcolepsy
|
0.600 |
Biomarker
|
disease |
MGD |
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes.
|
12797957 |
2003 |
|
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
HCRTR2-Abs are not common in narcolepsy unrelated to vaccination.
|
28364500 |
2017 |
|
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Among hypocretin replacement strategies, developing non-peptide hypocretin receptor agonists is currently the most encouraging since systemic administration of a newly synthesized, selective hypocretin receptor 2 agonist (YNT-185) has been shown to ameliorate symptoms of narcolepsy in murine models.
|
29623725 |
2018 |
|
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases.
|
29220370 |
2017 |
|
Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, 11 sporadic cases of canine narcolepsy and two additional multiplex families were investigated for possible Hcrt and Hcrtr2 mutations.
|
11282968 |
2001 |
|
Narcolepsy
|
0.600 |
Biomarker
|
disease |
CTD_human |
By using microarray technology we have screened the expression of 29760 genes in the brains of Doberman dogs with a heritable form of narcolepsy (homozygous for the canarc-1 [HCRTR-2-2] mutation), and their unaffected heterozygous siblings.
|
17521418 |
2007 |
|
Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study of American and Icelandic patients with narcolepsy, the authors found no significant association between narcolepsy and single-nucleotide polymorphisms in the genes for hypocretin or its two known receptors, hypocretin receptor-1 and hypocretin receptor-2.
|
11723285 |
2001 |
|
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
We detected autoantibodies against hypocretin in 3 patients, hcrtrl in 1 patient, and hcrtr2 in 5 patients with narcolepsy.
|
16774153 |
2006 |
|
Migraine Disorders
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Our study does not support a major contribution of the HCRTR2 G1246A polymorphism to the pathogenesis of migraine in contrast to its effects in cluster headache.
|
17883525 |
2007 |
|
Migraine Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
Our data suggest that the HCRTR2 gene is not a genetic risk factor in migraine.
|
17645762 |
2007 |
|
Mental Depression
|
0.030 |
Biomarker
|
disease |
BEFREE |
Moreover, 5-HT1AR and OX2R are involved in the pathogenesis of neurological diseases such as depression with deficiency of hippocampus plasticity.
|
30481562 |
2019 |
|
Mental Depression
|
0.030 |
Biomarker
|
disease |
BEFREE |
Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease).
|
27335043 |
2016 |
|
Mental Depression
|
0.030 |
Biomarker
|
disease |
BEFREE |
The results of the present study suggest that the C‑terminus of OX2R is important for its role in various physiological and pathological processes, and may therefore be associated with such disorders as depression and anorexia.
|
28487995 |
2017 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, OX2R is only detected in scattered malignant cells in high grade CaP.
|
24910418 |
2014 |
|
Hyperglycemia
|
0.200 |
Therapeutic
|
disease |
RGD |
Expressions of the prepro-orexin and orexin type 2 receptor genes in obese rat.
|
12217430 |
2002 |
|
Heart failure
|
0.030 |
Biomarker
|
disease |
BEFREE |
Indeed, OR-B, but not OR-A, by acting through orexin receptor-2 (OX2R), exerts direct cardioprotective effects in heart failure models.
|
30948623 |
2019 |
|
Heart failure
|
0.030 |
Biomarker
|
disease |
BEFREE |
Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure.
|
26653627 |
2015 |
|
Heart failure
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In human subjects with heart failure, there is a significant negative correlation between the expression of OX2R and the severity of the disease clinical symptoms, as assessed by the New York Heart Association (NYHA) functional classification.
|
30467191 |
2018 |
|
Excessive daytime sleepiness
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We discover loci associated with insomnia symptoms (near MEIS1, TMEM132E, CYCL1 and TGFBI in females and WDR27 in males), excessive daytime sleepiness (near AR-OPHN1) and a composite sleep trait (near PATJ (INADL) and HCRTR2) and replicate a locus associated with sleep duration (at PAX8).
|
27992416 |
2017 |
|
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
This loss was associated with hypermethylation of OX2R in EEC in comparison with normal endometrium (median CpG methylation percentages of 48.85% and 5.85%, respectively).
|
23482607 |
2013 |
|
Dyssomnias
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of the hypocretin/orexin receptor HCRTR2, which has been implicated in narcolepsy, correlated with sleep disturbance.
|
16376318 |
2006 |
|
Duration of sleep
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.
|
30846698 |
2019 |
|
Duration of sleep
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits.
|
27992416 |
2017 |
|
Depressive Symptoms
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Seltorexant (JNJ-42847922/MIN-202) is a selective antagonist of the human orexin-2 receptor (OX2R) that may normalize excessive arousal and thereby attenuate depressive symptoms.
|
31481683 |
2019 |
|
Depressive disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
Moreover, 5-HT1AR and OX2R are involved in the pathogenesis of neurological diseases such as depression with deficiency of hippocampus plasticity.
|
30481562 |
2019 |