HIF1A, hypoxia inducible factor 1 subunit alpha, 3091

N. diseases: 1044; N. variants: 15
Disease: Tumor Angiogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE The results suggest that Trx-1 increases HIF-1alpha protein levels in cancer cells and increases VEGF production and tumor angiogenesis. 12208766 2002
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE In conclusion, our findings provide evidence that GAB2 is a novel regulator of tumor angiogenesis in NRAS-driven melanoma through regulation of HIF-1α and VEGF expressions mediated by RAS-RAF-MEK-ERK signaling. 22926523 2013
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Vascular endothelial growth factor A (VEGFA), a critical mediator of tumor angiogenesis, is a well-characterized target of hypoxia-inducible factor 1 (HIF-1). 20194889 2010
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Hypoxia-inducible factor 1 (HIF-1) participates in tumor angiogenesis by upregulating target genes, such as vascular endothelial growth factor (VEGF). 29416751 2018
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 GeneticVariation phenotype BEFREE Overexpression of the HIF-1 alpha subunit, resulting from intratumoral hypoxia and genetic alterations, has been demonstrated in common human cancers and is correlated with tumor angiogenesis and patient mortality. 12615733 2003
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Blocking HIF-1alpha activity should not only downregulate tumor angiogenesis, but also interfere with glycolytic metabolism and tumor cell growth. 16294030 2005
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE It is suggested that the post-transcriptional down-regulation of HIF-1alpha expression by this agent may result in a decrease of VEGF expression and tumor angiogenesis. 11749701 2001
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE HIF-1alpha overexpression has been observed in many common human cancers, including brain, breast, colon, lung, ovary, and prostate, and HIF-mediated genes, such as vascular endothelial growth factor (VEGF), inducible nitric oxide synthase (iNOS), and insulin-like growth factor (IGF)-1, are associated with tumor angiogenesis, metastasis, and invasion. 20378243 2010
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE We put a special focus on the transcription factor HIF-1α, a master regulator of tumor angiogenesis.The interaction of CDK5 with HIF-1α was tested by Western blot, PCR, reporter gene assay, immunohistochemistry, kinase assay, co-immunoprecipitation, mass spectrometry, and mutation studies. 27027353 2016
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. 20308559 2010
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Taken together, our results show that apigenin suppresses tumor angiogenesis through HIF-1 and VEGF expression. 17071632 2007
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Artificial overexpression of miR-199a-5p decreased cell proliferation, motility, and tumor angiogenesis and increased apoptosis in PCa cell liness PC-3 and DU145 by directly targeting the 3'-untranslated region (UTR) of HIF-1α mRNA, which reduced HIF-1α levels as well as downstream genes transactivated by HIF-1α (such as VEGF, CXCR4, BNIP3 and BCL-xL). 29137361 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE It is well established that hypoxia potently stimulates tumor angiogenesis by activating hypoxia inducible factor-1 (HIF-1)-induced proangiogenic factors, such as vascular endothelial growth factor. 15994919 2005
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Moreover, F2 suppressed vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 expressions, followed by the inhibition of tumor angiogenesis and cell invasion in a HIF-1α-dependent manner. 25385044 2015
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Using ovarian and endometrial cancer cell lines, we observed that TM downregulates HIF-1α protein levels and HIF-transcriptional targets involved in tumor angiogenesis and glycolysis, but did not affect HIF-1α protein synthesis. 26469226 2015
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE The induction of vascular endothelial growth factor (VEGF) is an essential feature of tumor angiogenesis, and the hypoxia-inducible factor-1 (HIF-1) transcription factor is known to be a key mediator of this process. 14996738 2004
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Expression of NOS and HIF-1alpha in human colorectal carcinoma and implication in tumor angiogenesis. 16937436 2006
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Hypoxia-inducible factor 1 (HIF-1) plays essential roles in tumor angiogenesis and growth by regulating the transcription of several key genes in response to hypoxic stress and growth factors. 19575748 2009
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE DEK promotes tumor angiogenesis and growth in nude mice in HIF-1α-dependent and -independent manners. 26988756 2016
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity. 25535357 2015
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Although many studies have described the relationship between tumor angiogenesis and hypoxic environment, the roles of HIF-1 in cell invasion have been barely elucidated in malignant gliomas. 17332917 2007
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE In vivo topoisomerase I inhibition attenuates the expression of hypoxia-inducible factor 1α target genes and decreases tumor angiogenesis. 22033674 2012
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Therefore, heparanase and HIF-1α facilitated tumor angiogenesis and promoted pulmonary metastasis of osteosarcoma. 20845995 2010
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Previous studies have shown that Histone Deacetylase Inhibitors (HDACi) block tumor angiogenesis through the inhibition of HIF-1α expression. 25166596 2014
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. 30339780 2019