|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
HIF-1alpha overexpression has been observed in many common human cancers, including brain, breast, colon, lung, ovary, and prostate, and HIF-mediated genes, such as vascular endothelial growth factor (VEGF), inducible nitric oxide synthase (iNOS), and insulin-like growth factor (IGF)-1, are associated with tumor angiogenesis, metastasis, and invasion.
|
20378243 |
2010 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
HIF-1α expression allows metabolic adaptation to low oxygen availability, partly through upregulation of VEGF and increased tumor angiogenesis.
|
21084864 |
2011 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
HIF-1α is a key regulator of the cellular response to hypoxia and is involved in tumor angiogenesis and cancer cell survival, glucose metabolism, and invasion.
|
24485121 |
2014 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
HIF-1 (hypoxia-inducible factor-1) regulates the expression of more than 70 genes involved in angiogenesis, tumor growth, metastasis, chemoresistance, and radioresistance.
|
27263528 |
2016 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
HIF-1α expression varied with FBXO22, indicating that FBXO22 regulated the expression of HIF-1α and VEGFA and that FBXO22 was a regulator of HIF-1α and VEGF for the control of tumor angiogenesis.
|
30887251 |
2020 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
A novel class of agents, the histone deacetylase (HDAC) inhibitors, has been shown to inhibit tumor angiogenesis and HIF-1 alpha protein expression.
|
16951198 |
2006 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53.
|
30339780 |
2019 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Although many studies have described the relationship between tumor angiogenesis and hypoxic environment, the roles of HIF-1 in cell invasion have been barely elucidated in malignant gliomas.
|
17332917 |
2007 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Artificial overexpression of miR-199a-5p decreased cell proliferation, motility, and tumor angiogenesis and increased apoptosis in PCa cell liness PC-3 and DU145 by directly targeting the 3'-untranslated region (UTR) of HIF-1α mRNA, which reduced HIF-1α levels as well as downstream genes transactivated by HIF-1α (such as VEGF, CXCR4, BNIP3 and BCL-xL).
|
29137361 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Because hypoxia-inducible factor-1alpha (HIF-1alpha), its downstream target vascular endothelial growth factor (VEGF), and other angiogenic factors such as interleukin-8 (IL-8) and cyclooxygenase 2 (COX-2) play critical roles in neovascularization, we tested the hypothesis that the inhibitory effect of T3 on tumor angiogenesis is via regulation of these angiogenic factors.
|
18936210 |
2008 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Blocking HIF-1alpha activity should not only downregulate tumor angiogenesis, but also interfere with glycolytic metabolism and tumor cell growth.
|
16294030 |
2005 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
But it is unclear whether inhibition of HIF-1 alone is sufficient to block tumor angiogenesis.
|
16127434 |
2005 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Collectively, our data provide evidence of a positive cross-talk between HIF-1alpha and MTA1, which is mediated by HDAC1 recruitment, and indicate a close connection between MTA1-associated metastasis and HIF-1-induced tumor angiogenesis.
|
16511565 |
2006 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1α mediated tumor angiogenesis and proliferation.
|
30250643 |
2018 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
DEK promotes tumor angiogenesis and growth in nude mice in HIF-1α-dependent and -independent manners.
|
26988756 |
2016 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Disruption of the microtubule cytoskeleton impairs tumor angiogenesis by inhibiting the hypoxia-inducible factor (HIF-1α) pathway.
|
22367210 |
2012 |
|
Tumor Angiogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
DNA sequence variations in hypoxia-inducible factor-1alpha (HIF-1alpha) gene, which have been demonstrated to be correlated with tumor angiogenesis, may yield changes both in the production outcomes and in the activities of the gene.
|
18279708 |
2008 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
During tumor progression, hypoxia-inducible factor 1 (HIF-1) plays a critical role in tumor angiogenesis and tumor growth by regulating the transcription of several genes in response to a hypoxic environment and changes in growth factors.
|
26297910 |
2015 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
EGFR is involved in the tumor angiogenesis of HNSCC via the HIF-1α and Notch1 pathways.
|
25723392 |
2015 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Especially, hypoxia-inducible factor-1 (HIF-1)-dependent EC-specific mechanism is an essential component of tumor angiogenesis.
|
18566226 |
2008 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Ethanol enhances tumor angiogenesis in vitro induced by low-dose arsenic in colon cancer cells through hypoxia-inducible factor 1 alpha pathway.
|
22872060 |
2012 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of NOS and HIF-1alpha in human colorectal carcinoma and implication in tumor angiogenesis.
|
16937436 |
2006 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
First, we showed Pro-EGCG inhibited tumor angiogenesis in xenograft models through down-regulation of vascular endothelial growth factor A (VEGFA) and hypoxia inducible factor 1 alpha (HIF1α) in tumor cells and chemokine (C-X-C motif) ligand 12 (CXCL12) in host stroma by immunohistochemical staining.
|
29024813 |
2018 |
|
Tumor Angiogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Furthermore, hypoxia induces hypoxia-inducible factor-1 (HIF-1), which in turn increases tumor angiogenesis.
|
17563752 |
2007 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Herein, we have identified miR-519c as a hypoxia-independent regulator of HIF-1alpha, acting through direct binding to the HIF-1alpha 3' untranslated region and leading to reduced tumor angiogenesis.
|
20233879 |
2010 |