HIF1A, hypoxia inducible factor 1 subunit alpha, 3091

N. diseases: 1044; N. variants: 15
Disease: Tumor Angiogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 GeneticVariation phenotype BEFREE Overexpression of the HIF-1 alpha subunit, resulting from intratumoral hypoxia and genetic alterations, has been demonstrated in common human cancers and is correlated with tumor angiogenesis and patient mortality. 12615733 2003
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 GeneticVariation phenotype BEFREE DNA sequence variations in hypoxia-inducible factor-1alpha (HIF-1alpha) gene, which have been demonstrated to be correlated with tumor angiogenesis, may yield changes both in the production outcomes and in the activities of the gene. 18279708 2008
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 GeneticVariation phenotype BEFREE Overexpression of the HIF-1 alpha subunit, resulting from intratumoral hypoxia and genetic alterations, has been demonstrated in common human cancers and is correlated with tumor angiogenesis and patient mortality. 17418979 2007
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 GeneticVariation phenotype BEFREE Furthermore, hypoxia induces hypoxia-inducible factor-1 (HIF-1), which in turn increases tumor angiogenesis. 17563752 2007
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Vascular endothelial growth factor A (VEGFA), a critical mediator of tumor angiogenesis, is a well-characterized target of hypoxia-inducible factor 1 (HIF-1). 20194889 2010
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Hypoxia-inducible factor 1 (HIF-1) participates in tumor angiogenesis by upregulating target genes, such as vascular endothelial growth factor (VEGF). 29416751 2018
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE We put a special focus on the transcription factor HIF-1α, a master regulator of tumor angiogenesis.The interaction of CDK5 with HIF-1α was tested by Western blot, PCR, reporter gene assay, immunohistochemistry, kinase assay, co-immunoprecipitation, mass spectrometry, and mutation studies. 27027353 2016
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. 20308559 2010
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Artificial overexpression of miR-199a-5p decreased cell proliferation, motility, and tumor angiogenesis and increased apoptosis in PCa cell liness PC-3 and DU145 by directly targeting the 3'-untranslated region (UTR) of HIF-1α mRNA, which reduced HIF-1α levels as well as downstream genes transactivated by HIF-1α (such as VEGF, CXCR4, BNIP3 and BCL-xL). 29137361 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE It is well established that hypoxia potently stimulates tumor angiogenesis by activating hypoxia inducible factor-1 (HIF-1)-induced proangiogenic factors, such as vascular endothelial growth factor. 15994919 2005
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Moreover, F2 suppressed vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 expressions, followed by the inhibition of tumor angiogenesis and cell invasion in a HIF-1α-dependent manner. 25385044 2015
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Hypoxia-inducible factor 1 (HIF-1) plays essential roles in tumor angiogenesis and growth by regulating the transcription of several key genes in response to hypoxic stress and growth factors. 19575748 2009
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE DEK promotes tumor angiogenesis and growth in nude mice in HIF-1α-dependent and -independent manners. 26988756 2016
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Although many studies have described the relationship between tumor angiogenesis and hypoxic environment, the roles of HIF-1 in cell invasion have been barely elucidated in malignant gliomas. 17332917 2007
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Therefore, heparanase and HIF-1α facilitated tumor angiogenesis and promoted pulmonary metastasis of osteosarcoma. 20845995 2010
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. 30339780 2019
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE HIF-1α expression varied with FBXO22, indicating that FBXO22 regulated the expression of HIF-1α and VEGFA and that FBXO22 was a regulator of HIF-1α and VEGF for the control of tumor angiogenesis. 30887251 2020
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Vascular endothelial growth factor (VEGF), a crucial factor in tumor angiogenesis, has been reported to be transcriptionally regulated by hypoxia-inducible factor-1 (HIF-1). 30906512 2019
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE RLIP76 plays an essential role in tumor angiogenesis through the regulation of pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1 (HIF-1). 30999946 2019
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Collectively, our data provide evidence of a positive cross-talk between HIF-1alpha and MTA1, which is mediated by HDAC1 recruitment, and indicate a close connection between MTA1-associated metastasis and HIF-1-induced tumor angiogenesis. 16511565 2006
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Taken together, we suggest that Trx plays an important role in angiogenesis and, therefore, antisense-Trx might be applicable to the inhibition of tumor angiogenesis through the induction of pVHL-mediated HIF-1alpha degradation. 15754001 2005
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE These results demonstrate that BH4 domain of bcl-2 is required for the ability of this protein to increase tumor angiogenesis and progression and indicate that bcl-2 nuclear localization may be required for bcl-2-mediated induction of HIF-1/VEGF axis. 23836782 2013
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Recent studies show that HIF-1 plays a central role in angiogenesis, cancer and cardiovascular disease but also in bacterial infections. 27903434 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE This study aimed at determining the expression levels of HIF-1alpha and vascular endothelial growth factor (VEGF) in SW480 cells and in colorectal adenocarcinoma tissue and ascertaining whether HIF-1alpha and VEGF play important roles in tumor angiogenesis. 15498380 2004
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Herein, we have identified miR-519c as a hypoxia-independent regulator of HIF-1alpha, acting through direct binding to the HIF-1alpha 3' untranslated region and leading to reduced tumor angiogenesis. 20233879 2010