|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
We hypothesized that overexpression of ACE2 provides cardioprotective effects against MI via inhibiting HMGB1 and inflammation.
|
26498282 |
2016 |
|
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, a significant upregulation of gene and protein expressions of HMGB1 and its related TLR4 and NF-κB were observed in the MI group when compared with the sham group.
|
31280453 |
2019 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Non-oxidizable HMGB1 induces cardiac fibroblasts migration via CXCR4 in a CXCL12-independent manner and worsens tissue remodeling after myocardial infarction.
|
28716707 |
2017 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
High-dose intramyocardial HMGB1 induces long-term cardioprotection in sheep with myocardial infarction.
|
30859393 |
2019 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
HMGB1 injection into the mouse heart, acutely after myocardial infarction (MI), improves left ventricular (LV) function and prevents remodeling.
|
21731608 |
2011 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
TLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis.
|
31209243 |
2019 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Aim of the present study was to verify whether and how autophagy and apoptosis were involved in HMGB1-induced heart repair following myocardial infarction (MI).
|
27580416 |
2017 |
|
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
HG resulted in exacerbation of myocardial infarct size by 19% with amplified activation of HMGB1-receptors of advanced glycation end products/toll like receptors-NF-κB pathway compared to NG following I/R, which all could be attenuated by EP.
|
29169909 |
2018 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
High mobility group box-1 in hypothalamic paraventricular nuclei attenuates sympathetic tone in rats at post-myocardial infarction.
|
30338842 |
2019 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cardiac function, angiogenesis, and VEGF expression were impaired in the diabetic TG mice, but they were ameliorated by the DPP4 inhibition to levels similar to those found in the non-diabetic TG mice.The DPP4 inhibitor ameliorated cardiac function by inhibiting the inactivation of HMGB1 in diabetic mice after MI.
|
28966327 |
2017 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, platelet HMGB1 did not significantly correlate with LVEF, neither at baseline nor at 6 months follow-up of the MI subgroup, and did not exert any significant effect on outcome (composite of ACD and/or MI as well as single events ACD and MI).
|
29041001 |
2017 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
A significant increase in the number of HMGB1 positive cells was observed in the P.g.-inoculated MI group compared to the PBS-injected MI group.Infection with P.g. after MI enhanced myocardial HMGB1 expression.
|
28966323 |
2017 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Plasma and sputum HMGB1 levels did not correlate to disease severity (pneumonia severity index or presence of sepsis), but high sputum HMGB1 level was correlated to pneumococcal aetiology (p = 0.002).
|
30194360 |
2018 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In an experimental rat model of sepsis caused by cecal ligation and puncture (CLP), Gu-4 administration prominently attenuated lung injury and improved the survival of the septic animals, which was positively correlated with the decrease of the serum HMGB1 level.
|
24603876 |
2014 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
It is interesting that the patterns of change of HMGB1 and SAA over time were distinctive for SIRS and SEPSIS groups.
|
28680349 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, we suggested that miR-181a-5p may play a role in regulating DC responses to HMGB1 and serve as evidence indicating that novel therapies targeting miRNAs may be useful for treating immune dysfunction in the setting of sepsis.
|
28947753 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
High-mobility group box 1 (HMGB1) is a nuclear protein that has been found to be a critical mediator of lethality in endotoxemia and sepsis.
|
19097991 |
2009 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
High mobility group box 1 (HMGB1) plays a central role in the pathogenesis of sepsis and multiple organ dysfunction syndromes.
|
26632390 |
2016 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Collectively, the present study indicates that PBX 3'UTR may induce inflammatory responses and sepsis via acting as a competing endogenous RNA for HMGB1.
|
29484406 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The ubiquitous nuclear protein, high mobility group box 1 (HMGB1), is released by activated macrophages and human umbilical vein endothelial cells (HUVECs) and functions as a late mediator of experimental sepsis.
|
26224030 |
2015 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
HMGB1 is implicated as a late mediator of sepsis and is also involved in inflammatory and autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.
|
24809802 |
2014 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data reveal that H<sub>2</sub> gas could suppress lung injury in septic mice through regulation of HO-1 and HMGB1 expression and that Nrf2 plays a main role in the protective effects of H<sub>2</sub> gas on lung damage caused by sepsis.
|
30660872 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
M-BSA ameliorated LPS-induced sepsis and dextran sulfate sodium (DSS)-induced colitis models in which HMGB1 has been shown to play progressive roles.
|
28338748 |
2017 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition, simvastatin effectively reduced the intestinal levels of tumor necrosis factor α, interleukin-6, high-mobility group box 1, and malondialdehyde and increased the activity of superoxide dismutase in rats with sepsis.
|
30463769 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, our data suggest that HMGB1 accumulation in the late phase of sepsis plays a specific role in the development of postsepsis immunosuppression and specifically affects neutrophil-dependent antibacterial defense mechanisms.
|
27965385 |
2017 |