Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
We combined these results with our previous studies on HNF4alpha and TCF1 and explicitly tested for gene-gene interactions among these variants and with several known type 2 diabetes susceptibility loci, and we found no genetic interactions between these six genes.
|
17327436 |
2007 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
During the course of our search for susceptibility genes contributing to the more common late-onset NIDDM forms, we observed nominal evidence for linkage between NIDDM and markers in the region of the HNF-4alpha/MODY1 locus in a subset of French families with NIDDM diagnosed before 45 yr of age.
|
9449683 |
1998 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
We recommend inclusion of exon 1E and nearby DNA sequences in screening for HNF4alpha mutations and polymorphisms in genetic analyses of MODY1 and T2DM.
|
19353766 |
2009 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
Biomarker
|
disease |
BEFREE |
MODY is a form of NIDDM inherited as an autosomal dominant condition.
|
1628771 |
1992 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the HNF4A gene cause MODY1 and are associated with an increased risk of Type 2 diabetes mellitus.
|
30862908 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Genetic analysis revealed a novel variant (p.Pro190Leu) in HNF4A, which is located in the ligand binding domain of the transcription factor, and the p.Glu23Lys variant in KCNJ11, which is associated with type 2 diabetes.
|
26315042 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Neither PPARG2 Pro12Ala nor any of the nine HNF4A SNPs were independently associated with type 2 diabetes-related quantitative traits.
|
18162503 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Two low-frequency, non-synonymous variants in HNF4A (V255M, minor allele frequency [MAF] ~0.1%; T130I, MAF ~3.0%)-known to influence downstream HNF-4A target gene expression-are of interest, but previous type 2 diabetes association reports were inconclusive.
|
20878384 |
2011 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The four polymorphisms, rs4810424, rs1884613, rs1884614 and rs2144908, in the HNF‑4α gene were not the susceptible loci for type 2 diabetes in the Bai population of Dali city, however, the haplotype, CCTA, built from the four SNPs may increase the risk of type 2 diabetes in this population.
|
26781905 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
All 13 known MODY genes, genes identified from a genome-wide linkage study or genome-wide association studies as increasing the risk of type 2 diabetes and genes causing diabetes in animal models, were included in the custom panel.
|
25048417 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
Biomarker
|
disease |
BEFREE |
Our findings functionally link the miR-24/MODY gene regulatory pathway to the onset of type 2 diabetes and create a novel network between nutrient overload and genetic diabetes via miR-24.
|
23761103 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
MODY is genetically heterogeneous with five different genes identified to date: hepatocyte nuclear factor-4 alpha (HNF-4 alpha) [MODY1]; glucokinase [MODY2]; hepatocyte nuclear factor-1 alpha (HNF-1 alpha) [MODY3]; insulin promoter factor-1 (IPF-1) [MODY4]; and hepatocyte nuclear factor-1 beta (HNF-1 beta) [MODY5].
|
11058894 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
Biomarker
|
disease |
BEFREE |
This study considers the phenotypes that result from glucokinase defects and the relationship of MODY to NIDDM, and it estimates the role of glucokinase defects in NIDDM in general.
|
1397713 |
1992 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
A genome-wide association study reported FITM2-R3H domain containing like-HNF4A locus to be associated with type 2 diabetes (T2DM) in East Asian populations.
|
30020828 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
Biomarker
|
disease |
BEFREE |
Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY.
|
10588527 |
1999 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine whether alterations in known MODY genes and two MODY candidate genes contribute to the development of early-onset type 2 diabetes in Pima Indians.
|
10868855 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The results of the present analysis revealed that the HNF4A gene might be a type 2 diabetes susceptibility gene common to different ethnic groups.
|
16644680 |
2006 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Congenital hyperinsulinism and glycogenosis-like phenotype due to a novel HNF4A mutation.
|
28242437 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
LHGDN |
Half of clinically defined maturity-onset diabetes of the young patients in Denmark do not have mutations in HNF4A, GCK, and TCF1.
|
15928245 |
2005 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Concerning the Gly15Gly polymorphism, the TT genotype was found in 275 subjects (79.9%), the TG genotype in 67 subjects (19.5%) and the GG genotype in 2 subjects (0.6%): one with maturity onset diabetes of young age (MODY-diabetes) and one with Lipoatrophic Diabetes Syndrome (LPDS).
|
11029602 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
Biomarker
|
disease |
BEFREE |
Genetic association studies have provided evidence for a common genetic background (upstream transcription factor 1, activating transcription factor 6, transcription factor 7-like 2 and hepatocyte nuclear factor 4 alpha) between FCHL and T2DM.
|
20739883 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
Biomarker
|
disease |
BEFREE |
These monogenic forms of MODY have been used as model systems to investigate the inheritance and pathophysiology of type 2 diabetes.
|
10609119 |
1999 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the hepatocyte nuclear factor-1alpha gene in MODY and early-onset NIDDM: evidence for a mutational hotspot in exon 4.
|
9032114 |
1997 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The study included 72 patients with HNF1A-MODY, 72 with GCK-MODY, 53 with type 1 diabetes (T1DM), 70 with type 2 diabetes (T2DM), and 65 controls.
|
26347889 |
2015 |