|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
(2) We examined the association of three polymorphisms in the 5-HT2A receptor gene (HTR2A) with TD susceptibility--T102C(3) and his452tyr(4) in the coding region and A-1438G(5) in the promoter--in matched schizophrenia patients with (n = 59, SCZ-TD-Y) and without TD (n = 62, SCZ-TD-N) and normal control subjects (n = 96).
|
11317227 |
2001 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
5-HT(1A) partial agonists and 5-HT(2A) antagonists have shown modest effectiveness in improving cognition in schizophrenia.
|
15205874 |
2004 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
5-HT2A receptors are altered in schizophrenia and represent drug target for antipsychotic therapeutic activity.
|
31618004 |
2019 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A genetic association between schizophrenia and a silent C/T(102) polymorphism in the 5-HT2A receptor gene (5-HT2AR) has been previously reported; however, the mechanisms underlying this association remain unknown.
|
11891796 |
2002 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A genetic variant of the 5-HT2A receptor may be associated with neuroleptic-induced tardive dyskinesia in schizophrenia.
|
11526996 |
2001 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A number of studies have assessed a relationship between the T102C polymorphism in the HTR2A gene with an increased risk of major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SCZ).
|
24962835 |
2014 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.
|
26758213 |
2016 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Alterations in 5-HT(1A,) 5-HT(1B), and 5-HT(2A) mRNA levels in the brains of subjects with both mood disorders and schizophrenia add further support for hypothesis of dysregulation of the serotonergic system in these psychiatric disorders.
|
14744462 |
2004 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Alterations in 5-HT(1A,) 5-HT(1B), and 5-HT(2A) mRNA levels in the brains of subjects with both mood disorders and schizophrenia add further support for hypothesis of dysregulation of the serotonergic system in these psychiatric disorders.
|
14744462 |
2004 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Alterations in the 5-HT2A receptor gene expression in the prefrontal cortex have been suggested to play a role in the pathophysiology and pharmacotherapy of schizophrenia.
|
10650880 |
2000 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
LHGDN |
Although the association of schizophrenia with the C allele of HTR2A was confirmed by a meta-analysis 5 years ago, there was a continuous debate because negative findings were also considerable, which may have been due to ethnic differences in association.
|
14741324 |
2004 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although the association of schizophrenia with the C allele of HTR2A was confirmed by a meta-analysis 5 years ago, there was a continuous debate because negative findings were also considerable, which may have been due to ethnic differences in association.
|
14741324 |
2004 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the 5'-flanking promoter region of the 5-HT2A receptor gene in schizophrenia.
|
9326752 |
1997 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Another 5-HT(2A) receptor polymorphism consists of the silent thymidine-cytosine substitution (102T>C), which has been controversially associated with schizophrenia.
|
15037867 |
2004 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach.
|
17521439 |
2007 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Association between the 102T/C polymorphism of serotonin-2A receptor gene and schizophrenia among south Indians.
|
12140776 |
2002 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Association of a serotonin receptor 2A gene polymorphism with cognitive functions in patients with schizophrenia.
|
17221846 |
2007 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of a serotonin receptor 2A gene polymorphism with cognitive functions in patients with schizophrenia.
|
17221846 |
2007 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
RGD |
Chronic administration of risperidone in a rat model of schizophrenia: a behavioural, morphological and molecular study.
|
23291154 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Could HTR2A T102C and DRD3 Ser9Gly predict clinical improvement in patients with acutely exacerbated schizophrenia? Results from treatment responses to risperidone in a naturalistic setting.
|
17924589 |
2008 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
LHGDN |
Could HTR2A T102C and DRD3 Ser9Gly predict clinical improvement in patients with acutely exacerbated schizophrenia? Results from treatment responses to risperidone in a naturalistic setting.
|
17924589 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Cytosine methylation of HTR2A at T102C polymorphic site in DNA derived from the saliva can potentially be used as a diagnostic, prognostic, and/or therapeutic biomarker in SCZ and BD.
|
21598376 |
2011 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Data from animal experiments to determine the effect of agonists/antagonists at 5-HT(1A), 5-HT(2A), and 5-HT(2C) receptors on behavioral performance in animal models of schizophrenia based on the glutamatergic hypothesis provide useful information.
|
18839076 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder.
|
17221840 |
2007 |