Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of c-erbB2, TGF-beta 1 and pS2 genes in primary human breast cancers.
|
1350458 |
1992 |
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The human hSP gene, which contains a tandem duplication of the pS2 gene P domain and is coexpressed with the pS2 gene in normal stomach mucosa but not in breast cancers, is also expressed in Crohn's disease.
|
1985035 |
1991 |
Crohn Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The human hSP gene, which contains a tandem duplication of the pS2 gene P domain and is coexpressed with the pS2 gene in normal stomach mucosa but not in breast cancers, is also expressed in Crohn's disease.
|
1985035 |
1991 |
Mucosal ulcer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We suggest that pS2 gene expression may provide a useful marker for mucosal ulcerations of the digestive tract.
|
1985035 |
1991 |
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A 3.5 kb c-myb transcript band was detected in 108 (64%) tumours. c-myb expression was found to be associated with good prognostic factors (lowest histopathologic grade (P = 0.01), oestrogen and progesterone receptor status (P less than 10(-4)) and pS2 gene expression (P less than 10(-4)) and negatively correlated with breast cancers of poorer prognosis, namely IBC (P = 0.03) and NBC with multiple involved nodes (P = 0.15).
|
2181374 |
1990 |
Inflammatory Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A 3.5 kb c-myb transcript band was detected in 108 (64%) tumours. c-myb expression was found to be associated with good prognostic factors (lowest histopathologic grade (P = 0.01), oestrogen and progesterone receptor status (P less than 10(-4)) and pS2 gene expression (P less than 10(-4)) and negatively correlated with breast cancers of poorer prognosis, namely IBC (P = 0.03) and NBC with multiple involved nodes (P = 0.15).
|
2181374 |
1990 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 protein purified from conditioned medium of MCF-7 cells was S-pyridylethylated and digested with TPCK-trypsin.
|
2185238 |
1990 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 protein purified from conditioned medium of MCF-7 cells was S-pyridylethylated and digested with TPCK-trypsin.
|
2185238 |
1990 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 gene encodes for a small cysteine-rich protein, and was originally found by differential screening of a cDNA library from the human breast carcinoma cell line, MCF-7.
|
2290113 |
1990 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.
|
2303034 |
1990 |
Carcinoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In the present study, the expression of the pS2 gene was analyzed in 111 gynecological carcinomas.
|
2306733 |
1990 |
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
RNA blot hybridization analysis revealed that pS2 gene was expressed well in two (MKN-45 and KATO-III; derived from poorly differentiated adenocarcinoma) but not in three cell lines (MKN-1, MKN-28 and MKN-74; from well differentiated adenocarcinoma), suggesting that expression of the pS2 gene depends on the state of cell differentiation.
|
2311759 |
1990 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 gene is transcriptionally induced by oestrogen in the human breast cancer cell line MCF-7.
|
2450536 |
1988 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 gene is transcriptionally induced by oestrogen in the human breast cancer cell line MCF-7.
|
2450536 |
1988 |
Breast Fibrocystic Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The experiments described in this study examined responsiveness of peripheral blood lymphocyte mononuclear (MNC) cells, natural killer (NK) cells, T-helper (THC) cells, and NILL (cells obtained from patients with advanced breast cancer) cells from 10 of each age-matched subjects from 10 healthy adults and patients, 10 with benign breast diseases (BBD), and 10 from patients from each of the breast carcinoma pathological stage BCa PS I, BCa PS II, BCa PS III, and BCa PS IV.
|
2460238 |
1988 |
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of the pS2 gene which is transcriptionally controlled by oestrogens in the breast cancer cell line MCF-7 is oestrogen independent in stomach mucosa.
|
2498085 |
1989 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of the pS2 gene which is transcriptionally controlled by oestrogens in the breast cancer cell line MCF-7 is oestrogen independent in stomach mucosa.
|
2498085 |
1989 |
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
The 5' flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.
|
2498085 |
1989 |
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of the estrogen-regulated breast-cancer-associated pS2 gene was examined in 75 stomach resections taken from 45 patients.
|
2583860 |
1989 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of the estrogen-regulated breast-cancer-associated pS2 gene was examined in 75 stomach resections taken from 45 patients.
|
2583860 |
1989 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.
|
3041593 |
1988 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.
|
3041593 |
1988 |
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using these assays we show that determination of pS2 gene expression allows the definition of subclasses of estrogen-receptor-containing breast cancers that may be used to more precisely identify estrogen-dependent tumors.
|
3321071 |
1987 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of the pS2 gene, which is induced by estrogen in the breast cancer cell line MCF-7, has been investigated in breast cancers by using pS2 mRNA determination in tumor specimens and immunocytochemistry to identify pS2 protein in paraffin-embedded sections.
|
3321071 |
1987 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Using these assays we show that determination of pS2 gene expression allows the definition of subclasses of estrogen-receptor-containing breast cancers that may be used to more precisely identify estrogen-dependent tumors.
|
3321071 |
1987 |