|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7.
|
6593703 |
1984 |
|
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7.
|
6593703 |
1984 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using these assays we show that determination of pS2 gene expression allows the definition of subclasses of estrogen-receptor-containing breast cancers that may be used to more precisely identify estrogen-dependent tumors.
|
3321071 |
1987 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The human pS2 gene, whose expression is restricted to breast cancer cells, and whose transcription is induced by oestrogen in the human breast cancer cell line MCF-7, has been cloned from both placental and MCF-7 cell DNA.
|
3822834 |
1987 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of the estrogen-induced pS2 protein secreted by the human breast cancer cell line MCF-7.
|
3665845 |
1987 |
|
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The human pS2 gene, whose expression is restricted to breast cancer cells, and whose transcription is induced by oestrogen in the human breast cancer cell line MCF-7, has been cloned from both placental and MCF-7 cell DNA.
|
3822834 |
1987 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of the estrogen-induced pS2 protein secreted by the human breast cancer cell line MCF-7.
|
3665845 |
1987 |
|
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of the pS2 gene, which is induced by estrogen in the breast cancer cell line MCF-7, has been investigated in breast cancers by using pS2 mRNA determination in tumor specimens and immunocytochemistry to identify pS2 protein in paraffin-embedded sections.
|
3321071 |
1987 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Using these assays we show that determination of pS2 gene expression allows the definition of subclasses of estrogen-receptor-containing breast cancers that may be used to more precisely identify estrogen-dependent tumors.
|
3321071 |
1987 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.
|
3041593 |
1988 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 gene is transcriptionally induced by oestrogen in the human breast cancer cell line MCF-7.
|
2450536 |
1988 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 gene is transcriptionally induced by oestrogen in the human breast cancer cell line MCF-7.
|
2450536 |
1988 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.
|
3041593 |
1988 |
|
Breast Fibrocystic Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The experiments described in this study examined responsiveness of peripheral blood lymphocyte mononuclear (MNC) cells, natural killer (NK) cells, T-helper (THC) cells, and NILL (cells obtained from patients with advanced breast cancer) cells from 10 of each age-matched subjects from 10 healthy adults and patients, 10 with benign breast diseases (BBD), and 10 from patients from each of the breast carcinoma pathological stage BCa PS I, BCa PS II, BCa PS III, and BCa PS IV.
|
2460238 |
1988 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of the estrogen-regulated breast-cancer-associated pS2 gene was examined in 75 stomach resections taken from 45 patients.
|
2583860 |
1989 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of the pS2 gene which is transcriptionally controlled by oestrogens in the breast cancer cell line MCF-7 is oestrogen independent in stomach mucosa.
|
2498085 |
1989 |
|
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of the pS2 gene which is transcriptionally controlled by oestrogens in the breast cancer cell line MCF-7 is oestrogen independent in stomach mucosa.
|
2498085 |
1989 |
|
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of the estrogen-regulated breast-cancer-associated pS2 gene was examined in 75 stomach resections taken from 45 patients.
|
2583860 |
1989 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
The 5' flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.
|
2498085 |
1989 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A 3.5 kb c-myb transcript band was detected in 108 (64%) tumours. c-myb expression was found to be associated with good prognostic factors (lowest histopathologic grade (P = 0.01), oestrogen and progesterone receptor status (P less than 10(-4)) and pS2 gene expression (P less than 10(-4)) and negatively correlated with breast cancers of poorer prognosis, namely IBC (P = 0.03) and NBC with multiple involved nodes (P = 0.15).
|
2181374 |
1990 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 protein purified from conditioned medium of MCF-7 cells was S-pyridylethylated and digested with TPCK-trypsin.
|
2185238 |
1990 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 protein purified from conditioned medium of MCF-7 cells was S-pyridylethylated and digested with TPCK-trypsin.
|
2185238 |
1990 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 gene encodes for a small cysteine-rich protein, and was originally found by differential screening of a cDNA library from the human breast carcinoma cell line, MCF-7.
|
2290113 |
1990 |
|
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.
|
2303034 |
1990 |
|
Carcinoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In the present study, the expression of the pS2 gene was analyzed in 111 gynecological carcinomas.
|
2306733 |
1990 |