|
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
These four clones were transplanted into the ischemic core or penumbra of rats that had undergone middle cerebral artery occlusion (MCAO).
|
12075990 |
2002 |
|
Brain Ischemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
In experimental studies, the ischemic penumbra area can be targeted by gene transfer even after ischemic insult, and post-ischemic gene therapy seems effective in attenuation of ischemic damage in both global and focal brain ischemia.
|
12543276 |
2003 |
|
Brain Ischemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture.
|
12511777 |
2003 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Autoradiographic local cerebral blood flow (LCBF) studies at 2 hours of occlusion define the penumbra as a region of intermediate CBF depression (20% to 40% of control) surrounding the densely ischemic core (5% to 20% of control) and constituting one half of the entire lesion.
|
12511777 |
2003 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Autoradiographic local cerebral blood flow (LCBF) studies at 2 hours of occlusion define the penumbra as a region of intermediate CBF depression (20% to 40% of control) surrounding the densely ischemic core (5% to 20% of control) and constituting one half of the entire lesion.
|
12511777 |
2003 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Autoradiographic local cerebral blood flow (LCBF) studies at 2 hours of occlusion define the penumbra as a region of intermediate CBF depression (20% to 40% of control) surrounding the densely ischemic core (5% to 20% of control) and constituting one half of the entire lesion.
|
12511777 |
2003 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Following the onset of cerebral ischemia there is an increase in both tPA activity and neuroserpin expression in the area surrounding the necrotic core (ischemic penumbra), and treatment with neuroserpin following ischemic stroke or overexpression of the neuroserpin gene results in a significant decrease in the volume of the ischemic area as well as in the number of apoptotic cells.
|
14983220 |
2004 |
|
Acute Cerebrovascular Accidents
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We suggest that up-regulation of FGF-2 is one of the mechanisms that leads to angiogenesis and neuro-protection in the penumbra region after acute stroke in man.
|
16132618 |
2005 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previous work has demonstrated that angiogenesis occurs in the damaged brain tissue of patients surviving acute ischaemic stroke and increased microvessel density in the penumbra is associated with longer patient survival.
|
16132618 |
2005 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Our findings provide the first FISH evidence supporting the mapping of human Penumbra to 7q31.2 approximately q32 and demonstrate the potential of the Penumbra probe in the detection of 7q31 approximately q32-related deletions in myeloid malignancies.
|
16213355 |
2005 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This mechanism could be relevant in the pathogenesis of the electrophysiological changes in the penumbra region after stroke.
|
17053973 |
2006 |
|
Acute Cerebrovascular Accidents
|
0.100 |
Biomarker
|
disease |
BEFREE |
The target of acute stroke therapy is that portion of the ischemic region that is still potentially salvageable, i.e. the ischemic penumbra.
|
16651816 |
2006 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, they provide trophic support to tissue at risk in the penumbra surrounding the infarct area, enhance vasculogenesis, and help promote survival, migration, and differentiation of the endogenous precursor cells after stroke.
|
17474298 |
2007 |
|
Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Penumbra(-/-) mice develop massive splenomegaly, basophilic macrocytic red blood cells, and anemia as they age.
|
17158226 |
2007 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The human PENUMBRA gene is mapped to chromosome 7q32, a hot spot for deletions in myelodysplastic syndromes and acute myelogenous leukemias.
|
17158226 |
2007 |
|
MYELODYSPLASTIC SYNDROME
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The human PENUMBRA gene is mapped to chromosome 7q32, a hot spot for deletions in myelodysplastic syndromes and acute myelogenous leukemias.
|
17158226 |
2007 |
|
Cerebral Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the neuroprotective effects induced by transplantation of human embryonic neural stem cells (NSCs) into the cortical penumbra 24 h after focal cerebral ischemia.
|
19650809 |
2009 |
|
Acute Cerebrovascular Accidents
|
0.100 |
Biomarker
|
disease |
BEFREE |
These include the genetic factors in the aetiology and treatment of ischaemic stroke, the interplay between microvessels, neurons and glia (i.e., the microvascular unit) in the setting of acute stroke, a critical review of various neuroimaging techniques to visualize ischaemic tissue that is still viable (the ischaemic penumbra), recanalization strategies by means of intravenous thrombolysis as well as future recanalization techniques by, for example, intra-arterial or mechanical thrombolysis and sonothrombolysis by a transcranial approach.
|
20175862 |
2010 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
These include the genetic factors in the aetiology and treatment of ischaemic stroke, the interplay between microvessels, neurons and glia (i.e., the microvascular unit) in the setting of acute stroke, a critical review of various neuroimaging techniques to visualize ischaemic tissue that is still viable (the ischaemic penumbra), recanalization strategies by means of intravenous thrombolysis as well as future recanalization techniques by, for example, intra-arterial or mechanical thrombolysis and sonothrombolysis by a transcranial approach.
|
20175862 |
2010 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
The presence of apoptotic neurons in the ischemic penumbra and perihematoma area may account for poor prognosis, but whether the highly variable stroke outcome reflects differences in genetic susceptibility to apoptosis is elusive.
|
21357744 |
2011 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we show for the first time that treatment with TRC051384 significantly reduces stroke associated neuronal injury (87% reduction in area of penumbra recruited to infarct, and 25% reduction in brain edema) and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia.
|
21167846 |
2011 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show for the first time that treatment with TRC051384 significantly reduces stroke associated neuronal injury (87% reduction in area of penumbra recruited to infarct, and 25% reduction in brain edema) and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia.
|
21167846 |
2011 |
|
Cerebral Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
The compensatory angiogenesis that occurs after cerebral ischemia increases blood flow to the injured area and limits extension of the ischemic penumbra.
|
22833359 |
2012 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
This review highlights preclinical microarray findings of the ischemic brain, discusses the transcriptome of cerebral preconditioning and emphasizes the importance of further characterizing the role of the neurovascular unit and peripheral white blood cells in mediating stroke damage and repair within the penumbra.
|
22381515 |
2012 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
Further, EGFL7 became upregulated in vessels of the stroke penumbra using a mouse model of reversible middle cerebral artery occlusion.
|
23386126 |
2013 |