|
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further, EGFL7 became upregulated in vessels of the stroke penumbra using a mouse model of reversible middle cerebral artery occlusion.
|
23386126 |
2013 |
|
Brain Infarction
|
0.020 |
Biomarker
|
disease |
BEFREE |
Hyperlipidemia dose-dependently attenuated vascular endothelial growth factor-induced capillary formation and pericyte coverage of brain endothelial cells, abolishing the improvement of cerebral blood flow during subsequent stroke, resulting in the loss of the metabolic penumbra and increased brain infarction.
|
23559636 |
2013 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases.
|
24211713 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TSPAN33 is also expressed in some autoimmune diseases where B cells participate in the pathology, including rheumatoid arthritis patients, systemic lupus erythematosus (SLE), and in spleen B cells from MRL/Fas(lpr/lpr) mice (a mouse model of SLE).
|
24211713 |
2013 |
|
Lymphoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma.
|
24211713 |
2013 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases.
|
24211713 |
2013 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma.
|
24211713 |
2013 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma.
|
24211713 |
2013 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In a rat permanent middle cerebral artery occlusion model, TRPM4 was upregulated in the vascular endothelium within the penumbra region after stroke.
|
24043570 |
2014 |
|
Neuromyelitis Optica
|
0.010 |
Biomarker
|
disease |
BEFREE |
The penumbra was absent with NMO-IgG lacking both CDC and antibody-dependent cellular cytotoxicity (ADCC) effector functions.
|
24190619 |
2014 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Some cells from the oligodendroglioma grade III tumor proper shared molecular characteristics with the cells from the penumbra of the same tumor suggesting that a subpopulation of cells within the oligodendroglioma grade III tumor consisted of normal brain cells.
|
25249434 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the ischemic penumbra APN levels increased and peaked in T1DM-2W mice, and reduced to normal in T1DM-8W mice, while the APN receptor 1 (AdipoR1) expression change was the opposite.
|
26611106 |
2015 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fresh tumor tissue was obtained from one astrocytoma grade IV and one oligodendroglioma grade III tumor as well as the tumor penumbra of the latter tumor.
|
25249434 |
2015 |
|
oligodendroglioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Some cells from the oligodendroglioma grade III tumor proper shared molecular characteristics with the cells from the penumbra of the same tumor suggesting that a subpopulation of cells within the oligodendroglioma grade III tumor consisted of normal brain cells.
|
25249434 |
2015 |
|
Adult Oligodendroglioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Some cells from the oligodendroglioma grade III tumor proper shared molecular characteristics with the cells from the penumbra of the same tumor suggesting that a subpopulation of cells within the oligodendroglioma grade III tumor consisted of normal brain cells.
|
25249434 |
2015 |
|
Childhood Oligodendroglioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Some cells from the oligodendroglioma grade III tumor proper shared molecular characteristics with the cells from the penumbra of the same tumor suggesting that a subpopulation of cells within the oligodendroglioma grade III tumor consisted of normal brain cells.
|
25249434 |
2015 |
|
Well Differentiated Oligodendroglioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Some cells from the oligodendroglioma grade III tumor proper shared molecular characteristics with the cells from the penumbra of the same tumor suggesting that a subpopulation of cells within the oligodendroglioma grade III tumor consisted of normal brain cells.
|
25249434 |
2015 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
A previous animal study demonstrated an increased expression of the endocannabinoid receptor 1 (CB1R) in the penumbra area surrounding the ischemic core, suggesting a crucial role in inflammation/reperfusion after stroke.
|
27425766 |
2016 |
|
Cerebral Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nitrites and BDNF may represent potential biomarkers for cortisol negative effects on the area of cerebral ischemia and penumbra, potentiating ischemic cell damage.
|
28982330 |
2017 |
|
Cerebral Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dodecafluoropentane emulsion (DDFPe), an advanced oxygen transport drug, given IV at 90-min intervals maintains viability in the penumbra during cerebral ischemia in the standard rabbit anterior stroke model (STND).
|
27501802 |
2017 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
Variation in collateral extent significantly alters infarct volume expansion, transiently affects perfusion and diffusion magnetic resonance imaging signatures, and impacts salvage of ischemic penumbra after stroke onset.
|
28188261 |
2017 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
Our experience indicates that CEA performed early after IVT for acute ischemic stroke, aiming not only to reduce the risk of stroke recurrence but also to achieve neurological improvement by reperfusion of the ischemic penumbra, may be safe and can lead to favorable outcomes.
|
28479465 |
2017 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
The results revealed that SIRT2 was mainly expressed in the cytoplasm and neurites of neurons in the brains of normal subjects, while an elevated expression and nuclear translocation of SIRT2 were detected in the ischemic penumbra of cerebral stroke.
|
27796760 |
2017 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
Improvement in acute 24-hour National Institutes of Health Stroke Scale was also significantly related to the degree of reperfused penumbra (<i>R</i><sup>2</sup>, 0.31; P<0.0001).
|
28887396 |
2017 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
This study was to investigate the efficacy of puerarin on autophagy in the ischemic penumbra after cerebral stroke.
|
28192195 |
2017 |