|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The results showed FBG, FINS and HOAM-IR in CUG-FGR group were higher than those in high fat feeding control group (NC+HF), but the content of IGF-1 in blood was lower than that in NC + HF group.
|
29442728 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
There was no significant difference in the levels of transcripts for IGF1, insulin receptor, or IGF2R between normal and IUGR term placentas.
|
9491374 |
1998 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
LHGDN |
There was a significant positive correlation between aIMT and gestational age, whereas a significant negative correlation was determined between aIMT and IGF-I in the IUGR neonates.
|
17957164 |
2007 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
There were significantly lower concentrations of glucose, insulin, IGF-1, and IGF-II in the fetal cord blood of pregnancies with IUGR (p<0.05).
|
20106611 |
2010 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
These findings strongly suggest that this mutation leads to failure of processing of the IGF-IR proreceptor to mature IGF-IR and causes short stature and IUGR.
|
15928254 |
2005 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
These results demonstrate that the molecular machinery necessary for transcriptional control of proliferation remains intact in IUGR fetal myoblasts, indicating that in vivo factors such as reduced insulin and IGF1, hypoxia and/or elevated counter-regulatory hormones may be inhibiting muscle growth in IUGR fetuses.
|
28053000 |
2017 |
|
Fetal Growth Retardation
|
0.400 |
Therapeutic
|
phenotype |
RGD |
To investigate the effects of early nutritional intervention on the serum insulin-like growth factor-1 (IGF1), insulin-like growth factor binding protein 3 (IGFBP3), intestinal development, and catch-up growth of intrauterine growth retardation (IUGR) rats by giving the IUGR new born rats different protein level diet.
|
15506645 |
2004 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
RGD |
To investigate the expressions of the insulin receptor (IR), insulin receptor substrate-1 (IRS-1), insulin receptor substrate-2 (IRS-2), phosphatidyl inositol 3-kinase (PI3K) and insulin-like growth factor-1 (IGF-1) of the livers of the male adult rats born with intrauterine growth retardation (IUGR),and to find out the relationship between IUGR and insulin resistance in their adult life.
|
19088829 |
2008 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Various mechanisms leading to the increased transcription of IGF-I and PGH mRNA in IUGR placenta are discussed.
|
11228249 |
2001 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We investigated the effects of intra-amniotic IGF1 administration to ovine fetuses with uteroplacental embolisation-induced FGR on phenotypical and physiological characteristics in the 2 weeks after birth.
|
29235113 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
With the first descriptions of patients born small for gestational age carrying mutations within the insulin-like growth factor type 1 receptor (IGF-1R) gene, genetic defects at the lower end of the GH-IGF-1 axis were identified as a monogenetic cause of intrauterine growth retardation.
|
23182819 |
2012 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Women in the IUGR group were smaller than in the control group (p < 0.05), and, using the covariance test (p < 0.05), this was found to be correlated with IGF-I levels but not with EGF or TGF-beta levels.
|
11903419 |
2001 |