|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma.
|
12584565 |
2003 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings indicated that independent deregulation took place in imprinted genes and suggested that aberrant imprinting of IGF2 and MEST was involved in the development of lung adenocarcinoma.
|
11536368 |
2001 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical IGF-II expression was also more frequently detected in pT1 cancer (58.3%) than in adenoma (25.3%).
|
15585629 |
2004 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, IGF-II transcripts derived from the P3 promoter are highly expressed in salivary gland adenomas overexpressing PLAG1.
|
10646861 |
2000 |
|
Adenoma
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
In colon cancer, we have shown a pattern of age-related methylation for several genes, including ER, IGF2, N33 and MyoD, which progresses to full methylation in adenomas and neoplasms.
|
10963127 |
2000 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
IGF-2 was the most useful biomarker of malignancy irrespective of tumor grade and cytomorphologic features, as juxtanuclear Golgi-pattern IGF-2 reactivity optimized for high specificity was identified in up to 80% of carcinomas and in no adenomas.
|
28877067 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Persons with CRN (adenomas/cancer) had 5.1-fold (95% CI: 1.92-13.6) increased risk of having LOI of IGF2 in PBL compared with those without CRN.
|
15057734 |
2004 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
With the combination of stabilized β-catenin and elevated Igf2 expression, adrenal glands were larger, displayed earlier onset of hyperplasia, and developed more frequent macroscopic adenomas (as well as one carcinoma).
|
22800756 |
2012 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results suggest that overexpression of IGF-II played an important role in the progression of adenoma to carcinoma in this patient.
|
15490195 |
2005 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Very high IGF-II mRNA contents were detected in seven tumors (30%; 5 of the 6 carcinomas and 2 of the 17 adenomas).
|
7911125 |
1994 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We evaluated the association between LOI of IGF-II in normal colonic mucosal samples and adenomas in women participating in a colonoscopy screening study.
|
14996863 |
2004 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Distal adenoma risk was significantly increased for one SNP in IGF2 [per minor allele OR = 1.41; 95 % confidence interval (CI) = 1.16, 1.67; P (act) = 0.005] and decreased for an ESR2 SNP (per minor allele OR = 0.78; 95 % CI = 0.66, 0.91; P (act) = 0.041).
|
22645077 |
2012 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We examined the association of circulating levels of IGF-1, IGFBP-3 and IGFBP-1, and SNPs in the IGF-1 receptor (IGF1R), IGF-2 receptor (IGF2R), and insulin receptor genes with risk of adenomas in a sample of 410 incident adenoma cases and 1,070 controls from the Case Transdisciplinary Research on Energetics and Cancer (TREC) Colon Adenomas Study.
|
24194259 |
2014 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Constitutive loss of imprinting (LOI) of IGF2 has been associated with increased risks of colon cancer and adenoma, indicating its role in carcinogenesis.
|
20682317 |
2010 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Microarray gene expression and immunohistochemistry analyses of adrenocortical tumors identify IGF2 and Ki-67 as useful in differentiating carcinomas from adenomas.
|
19218281 |
2009 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Hormonally active adrenocortical carcinomas and virilizing adenomas express insulin-like growth factor II gene abundantly.
|
9694575 |
1998 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of ghrelin and IGF2 in a total of 84 adrenal tissue samples (30 adenoma, 12 hyperplasia, 8 myelolipoma, 20 pheochromocytoma, 7 carcinoma and 7 unchanged adrenal glands) were estimated.
|
29682767 |
2018 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We evaluated the methylation levels of IGF2 DMR0 and long interspersed nucleotide element-1 (LINE-1) in HPs (n = 115), SSAs (n = 120), SSAs with cytological dysplasia (n = 10), TSAs (n = 91), TSAs with high-grade dysplasia (HGD) (n = 15), non-serrated adenomas (n = 80), non-serrated adenomas with HGD (n = 105), and CRCs (n = 794).
|
25110432 |
2014 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
LHGDN |
IGF-II transcripts were overexpressed in both pediatric adrenocortical carcinomas and adenomas.
|
18611974 |
2008 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression levels of members of the insulin receptor family (INSR, IGF1R, IGF2R, GHR) and their ligands IGF1and IGF2 were quantified in macro- and microdissected tissue samples of normal canine mammary gland, adenomas, carcinomas and their lymph node metastases to evaluate their potential impact on the carcinogenesis of canine mammary tumours.
|
21062411 |
2010 |
|
Adenoma of large intestine
|
0.020 |
Biomarker
|
disease |
BEFREE |
These data suggest that selected genetic variability in IGF2 and ESR2 may be modifiers of CRA risk.
|
22645077 |
2012 |
|
Adenoma of large intestine
|
0.020 |
Biomarker
|
disease |
BEFREE |
Loss of insulin-like growth factor-II imprinting and the presence of screen-detected colorectal adenomas in women.
|
14996863 |
2004 |
|
Adenomatous Polyposis Coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
Quantitative methylation analysis using pyrosequencing was performed on three differentially methylated regions (DMRs): IGF2 DMR0 and DMR2 and the H19 DMR in DNA samples from sporadic colorectal cancer (n = 26), familial adenomatous polyposis (n = 35) and hereditary nonpolyposis colorectal cancer (n = 19) patients.
|
22121898 |
2010 |
|
Adenomatous Polyps
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
SFRP2 and IGF2 DMR0 showed significant methylation changes at the adenomatous polyp stage, followed by the CIMP markers CDKN2A and hMLH1 at the adenocarcinoma stage.
|
21068132 |
2011 |
|
Adrenal Cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Similarities exist between normal human fetal adrenal cortex and adrenal cancers, such as high expression of growth factors, including insulin-like growth factor II.
|
15949953 |
2005 |