|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest a novel molecular mechanism responsible for the tumor suppressive function of IGFBP7 in cisplatin-resistant human lung cancer and could lead to the development of IGFBP7 as a cisplatin-sensitizing agent.
|
22277373 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Results demonstrate that CpG methylation of IGFBP7 may represent a novel biomarker of prostate cancer and pre-invasive neoplasms.
|
22906661 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Genome expression analysis revealed that STAT3 knockdown resulted in the down-regulation of multiple transcripts, including the tumor suppressor insulin-like growth factor binding protein 7.
|
22891351 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The important role of insulin-like growth factor binding protein 7 (IGFBP7) as a tumor suppressor in solid tumors has been revealed in several studies.
|
21040219 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Insulin-like growth factor-binding protein 7 (IGFBP7) has been identified as a tumor suppressor in solid tumors.
|
21413833 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Insulin-like growth factor binding protein 7 (IGFBP7) was considered a tumor suppressor gene in lung cancer.
|
21095038 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The present study focuses on analyzing potential tumor suppressor functions of IGFBP7 in HCC and the relevance of IGFBP7 downregulation in mediating AEG-1 function.
|
21908579 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Similar to oncogenic BRAF-positive common naevi without atypia, enhanced expression of the tumour suppressor IGFBP7 in oncogenic BRAF-positive AGN supports that they are biologically inert.
|
19919630 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to ascertain the utility of the RAF/RAS mutational status as a diagnostic adjunct in lesions with histologic features that deviate from a typical Spitz nevus and, to examine expression of Insulin growth factor binding protein 7 (IGFBP7), a tumor suppressor acting through autocrine/paracrine pathways to inhibit BRAF-MEK-ERK signaling, in the same.
|
19788444 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Loss of IGFBP7 expression is a critical step in the development of human tumors, including melanoma and colon cancer.
|
20440262 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Similarly, the anti-IGFBP7 sdAb-functionalised PEGylated Fe₃O₄ NP-Cy5.5 demonstrated enhanced tumour signal compared with non-targeted NPs.
|
20959824 |
2010 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Further functional analysis showed that the IGFBP7 -418A allele had significantly higher promoter and DNA-protein binding activities than did the G allele, suggesting a tumor suppressor role of this allelic change in the SCCHN etiology.
|
20599521 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In our previous studies, we have demonstrated that insulin-like growth factor binding protein-related protein1 (IGFBP-rP1) played its potential tumor suppressor role in colon cancer cells through apoptosis and senescence induction.
|
20977730 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Oncogenic BRAF has been shown to induce senescence/apoptosis by up-regulating the tumor suppressor IGFBP7, which acts through autocrine/paracrine pathways to inhibit BRAF-MEK-ERK signaling.
|
20233623 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of VL30-1 RNA is 5- to 8-fold higher in mouse tumor lines than in mouse fibroblast or myoblast lines, whereas expression of PSF mRNA does not decrease in the tumor lines, suggesting that tumorigenesis is driven by an increase of VL30-1 RNA rather than a decrease of PSF.
|
19805375 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The morphologic and immunohistochemical discrepancies between this intriguing melanotic tumor and other documented renal cell carcinomas bearing identical PSF-TFE3 gene fusion may suggest melanotic Xp11 translocation renal cancer is a distinct entity among the MiT/TFE family neoplasms.
|
19809274 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Restoration of IGFBP7 function by the addition of recombinant IGFBP7 (rIGFBP7) induces apoptosis in BRAF-positive human melanoma cell lines, and systemically administered rIGFBP7 markedly suppresses the growth of BRAF-positive primary tumors in xenografted mice.
|
19861408 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of angiomodulin (AGM), a vascular endothelial growth factor (VEGF)-A binding protein, was increased in the vasculature of several human tumors as compared to normal tissue, raising the hypothesis that AGM may modulate VEGF-A-dependent vascular patterning.
|
19542015 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
While PSF can function as a DNA-binding protein with a tumor suppressive function, its association with Hakai promotes PSF's RNA-binding ability and post-transcriptional influence on target mRNAs.
|
19855157 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Insulin-like growth factor-binding protein 7 (IGFBP7) is a selective biomarker of glioblastoma (GBM) vessels, strongly expressed in tumor endothelial cells and vascular basement membrane.
|
18711401 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results uncovered a novel molecular mechanism involving the altered expression of pRB and p53 for tumor suppressor gene IGFBP-rP1 in colorectal cancer.
|
18701096 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The data suggest that IGFBP-rP1 is a tumour suppressor inactivated by DNA methylation in human lung cancer.
|
17236181 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results demonstrate that IGFBP-rP1 strongly suppresses tumor growth by an insulin-independent or insulin-like growth factor-independent mechanism.
|
17465992 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Based on above results, we conclude that IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis.
|
17312390 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The analysis of 37 paired cancerous and normal mucosa samples confirmed the downregulation in the tumors, but revealed variable basal expression levels of IGFBP-7 in normal mucosal samples.
|
17136345 |
2007 |