|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, our study clearly demonstrated that IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis and its expression is associated with DNA hypomethylation of exon 1.
|
17048309 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor samples with upregulated expression of IGFBP-rP1 in invading tumor cells showed an increased frequency of metastasis to the lymph node, an increased depth of infiltration and stronger staining of IGFBP-rP1 compared with other samples (P<0.05).
|
15027891 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Further analysis of RNA and protein expression in breast tumor cell lines and patient tissue samples revealed that: IGFBP-rP1 is down-regulated in invasive tumors whereas cyclin I protein is regulated by ubiquitination and is associated with ER-negative breast cancers.
|
12894577 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We hypothesize that IGFBP-rP1 has a tumor-suppressive effect on prostate cancer growth and its inactivation is through CpG hypermethylation.
|
14633696 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mac25 LNCaP cells had a marked decrease in tumor growth in nude mice compared to controls, but there was no difference in tumor growth in mac25 PC-3 cells compared to control.
|
12592389 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Over-expression of insulin-like growth factor binding protein-related protein-1(IGFBP-rP1/mac25) in the M12 prostate cancer cell line alters tumor growth by a delay in G1 and cyclin A associated apoptosis.
|
11791184 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, IGFBP-rP1 showed an inverse association with proliferation (Ki-67%) in estrogen receptor negative tumors as well as in cyclin E high tumors suggesting a separate cell cycle regulatory function for IGFBP-rP1 independent of interaction with the estrogen receptor or the pRb pathway.
|
11429696 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently it has been suggested that mac25 plays a tumor-suppressive role in various tumors.
|
10698042 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results indicated that the degree of methylation was inversely related to the expression level and is consistent with a role for DNA methylation in silencing mac25/Igfbp-7 gene expression and function for mac25/Igfbp-7 as a tumor suppressor gene.
|
10623583 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast to these results, tumor xenografts generated by direct intraosseous injection of LNCaP or C4-2 to bone marrow space resulted in tumors that stained positively for IGFBP-rP1.
|
10383131 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The M12 clones overexpressing IGFBP-rP1 had a dose-related increase in population doubling time, decreased colony formation in soft agar, an increased propensity to undergo apoptosis in response to 6-hydroxyurea, and decreased tumor formation in male athymic, nude mice.
|
10344746 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
T1A12/mac25 may therefore have a tumor suppressor-like function and its expression could indicate a disease with a more favorable status, having a better prognosis.
|
9627112 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, there is no evidence for compensation of p53 function by mac25 in the development of p53-deficient mice, as judged from the pattern of expression of mac25 in mice. mac25 might act as a tumor suppressor, modulating signaling of the TGF-beta family, as does alpha-inhibin.
|
8649839 |
1996 |