|
Anorexia Nervosa
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Plasma levels of the pro-inflammatory cytokines TNF-α and IL-1β were significantly increased in patients with AN, while the levels of prostaglandins PGE<sub>2</sub> (proinflammatory) and 15d-PGJ<sub>2</sub>, (anti-inflammatory) were lower compared with controls.
|
31398429 |
2020 |
|
Constipation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our results suggest that neurotrophic factors and IL-1β are closely related to IBS-constipation and that decrease of ZO-1 is an important factor in female with IBS-diarrhea.
|
31623029 |
2020 |
|
Pressure Ulcer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The infected and irradiated PUs exhibited a thinner neo-epidermis than those in the infected group, and the bacterial survival decreased in the laser group; the relative expression IL-1β mRNA levels demonstrated an increasing tendency while the relative expression IL-10 mRNA levels demonstrated a decreasing tendency in the infected + laser and laser groups.
|
31473868 |
2020 |
|
Enteritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that, compared with the control group, dietary CT (1) induced intestinal histopathological lesions and aggravated enteritis; (2) decreased the lysozyme and acid phosphatase activities, complement 3 (C3), C4 and immunoglobulin M contents, and down-regulated the Hepcidin, liver-expressed antimicrobial peptide(LEAP)-2A, LEAP-2B, Mucin2 and β-defensin-1 mRNA levels in the proximal intestine (PI), mid intestine (MI) and distal intestine (DI) (P < 0·05); (3) down-regulated the mRNA levels of anti-inflammatory cytokines transforming growth factor (TGF)-β1, TGF-β2 (not in MI and DI), IL-4/13A (not IL-4/13B), IL-10 and IL-11 partly correlated with target of rapamycin (TOR) signalling; (4) up-regulated the mRNA levels of pro-inflammatory cytokines interferon-γ2 (IFN-γ2), interleukin-1β (IL-1β), IL-6, IL-8 (not in PI), IL-12p35, IL-12p40, IL-15 and IL-17D partly related to nuclear factor kappa B (NF-κB) signalling in the intestine of on-growing grass carp.
|
31831090 |
2020 |
|
Klebsiella Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Elevated urinary IL-1β levels in multidrug resistant Escherichia coli and Klebsiella infections.
|
31820023 |
2020 |
|
Lymphohistiocytosis, Hemophagocytic
|
0.010 |
Biomarker
|
disease |
BEFREE |
CD8+ T cells and the IL-33/ST2 axis remained essential mediators of disease; however, IFNγ-independent HLH immunopathology correlated with a 10-15-fold increase in neutrophilia (P < 0.001) and an altered cytokine milieu dominated by IL-6, IL-1β, and granulocyte-macrophage colony-stimulating factor (GM-CSF) (P < 0.05).
|
31400073 |
2020 |
|
Melancholia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with MDD with melancholic features showed higher IL-1β levels than those without melancholia.
|
31693974 |
2020 |
|
Peyronie Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In vitro model of PD was designed using experimental model of inflammation induced by Interleukin-1 (IL-1) in cultured fibroblasts and mechanical damage of the cells.
|
31733276 |
2020 |
|
Pleural effusion disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
IL-1β, HMGB1, HO-1, and LDH in the pleural effusions (PE) of patients with transudative, infectious, and malignant etiologies were determined using ELISA and enzymatic assays.
|
31639457 |
2020 |
|
Pulpitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry was used to compare interleukin-1β (IL-1β) and osteocalcin (OCN) expression in the pulpitis model.
|
31419325 |
2020 |
|
Recurrent urinary tract infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-1β has been implicated in the differentiation of symptomatic and asymptomatic urinary tract infections, but its role in MDR infections has not been elucidated.
|
31820023 |
2020 |
|
Hemophilic arthropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The cascade starts with iron accumulation leading to an increase in CD<sup>68+</sup> and CD<sup>11b+</sup> cells responsible for initiating the inflammation.<b>Areas covered</b>: During inflammation, different factors and cytokines such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor α (TNF-α) actively play parts in the pathogenesis of HA and also angiogenesis.
|
31657968 |
2020 |
|
Laryngomalacia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Presence and level of salivary pepsin was not significantly associated with need for surgical management, nor were the levels or presence of IL-1β or IL-8 significantly associated with presence or level of pepsin, diagnosis of laryngomalacia, or need for operative management.
|
31631681 |
2020 |
|
Idiopathic generalized epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Neuroinflammation is an important feature of epileptogenesis.<b>Objectives:</b> To investigate the association of Interleukin-1beta-31 (IL-1β-31) and Interleukin-1 receptor antagonist (IL1-RA) genetic polymorphisms with idiopathic generalized epilepsy and demonstrate their influence on drug resistance in children.<b>Materials and Methods:</b> One hundred children with idiopathic generalized epilepsy were age and gender-matched with apparently healthy controls.
|
31698971 |
2020 |
|
Juvenile disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Response to IL-1 blockade was assessed by (1) clinical response (at least initial response compared to poor response), (2) switch to anti-IL-6 receptor therapy following IL-1 blockade or not (3) clinically inactive disease within 6 months of IL-1 blockade, (4) modified juvenile disease activity score and (5) reaching of a glucocorticoid free state.
|
31599092 |
2020 |
|
Caries (morphologic abnormality)
|
0.010 |
Biomarker
|
disease |
BEFREE |
This controlled split-mouth study aimed to estimate the effect of caries and related treatment on concentrations of interleukin (IL)-2, interferon (IFN)-γ, IL-12, IL-17A, IL-13, IL-10, IL-6, IL-5, IL-4, IL-22, tumor necrosis factor (TNF)-α, and IL1-β in gingival crevicular fluid (GCF) of caries affected teeth before (B), 7 (7D) and 30 (30D) days post-treatment and to compare them with concentrations from healthy teeth.
|
31791000 |
2020 |
|
Supragingival dental plaque
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subjective pain (assessed by visual analogue scale in pain diary and by chairside archwire activation), periodontal status (assessed by periodontal clinical parameters), cytokines in gingival crevicular fluid (interleukin 1β, prostaglandin E<sub>2</sub>, substance P) and periodontopathic bacteria (Porphyromonas gingivalis and Treponema denticola) in supragingival plaque were assessed.
|
31833004 |
2020 |
|
Acute low back pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
To investigate the association between plasma levels of inflammatory cytokines (interleukin [IL]-1-β, IL-6, tumor necrosis factor [TNF]-α, and the soluble TNF receptor 1 [sTNF-R1]), disability, and risk of falls in older women with acute low back pain (LBP).
|
31606818 |
2020 |
|
Nephronophthisis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Herein, we show that the NF-κB signaling is active in Glis2 knockout kidney epithelial cells and that genetic inactivation of the toll-like receptor (TLR)/IL-1 receptor or pharmacologic elimination of senescent cells (senolytic therapy) reduces tubule damage, fibrosis, and apoptosis in the Glis2 mouse model of NPHP.
|
31676329 |
2020 |
|
Acute encephalopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cerebrospinal fluid levels of granzyme A were significantly higher, and those of TNF-α and IL-1RA were significantly lower in the AE group than in the cFS group; however, no significant differences in the levels of granzyme B, IFN-γ, IL-1β, IL-4, IL-6, IL-8, and IL-10 were observed between the 2 groups.
|
31709864 |
2020 |
|
Pneumonia, Ventilator-Associated
|
0.010 |
Biomarker
|
disease |
BEFREE |
The VAPrapid2 trial aimed to determine whether measurement of bronchoalveolar lavage fluid IL-1β and IL-8 could effectively and safely improve antibiotic stewardship in patients with clinically suspected ventilator-associated pneumonia.
|
31810865 |
2020 |
|
Alcoholic Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Deletion of GSDMD reduced IL-1β release and ameliorated alcoholic steatohepatitis in vivo.
|
31670032 |
2020 |
|
Nonrheumatic aortic (valve) stenosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Peripheral blood IL-1 family mRNA and protein levels in NR-AS patients and healthy adults were quantified by real-time quantitative polymerase chain reaction (RT-qPCR) and enzyme-linked immunosorbent assay.
|
31416779 |
2020 |
|
RETINOSCHISIS 1, X-LINKED, JUVENILE
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RA+RS signifificantly decreased the diastolic blood pressure, renal vascular resistance index, and parenchymal thickness, increased 24 h urinary volume as well as lowered the levels of urine mALB and serum cystatin ^C, IL-1β and β2-Mg of SHRs (P <0.05 vs. SHRs).
|
31388973 |
2020 |
|
Acute alcoholic liver disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Proinflammatory cytokine expression, including IL-1β and IL-23, was also higher than in healthy controls, but both classical (CD14<sup>++</sup>CD16<sup>-</sup>) and intermediate monocytes in AH were refractory to TLR stimulation.
|
31722987 |
2019 |