|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Gastritis, Atrophic
|
0.490 |
Biomarker
|
disease |
HPO |
|
|
|
|
GASTRIC CANCER SUSCEPTIBILITY AFTER H. PYLORI INFECTION
|
0.100 |
SusceptibilityMutation
|
phenotype |
CLINVAR |
|
|
|
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
RGD |
"[Exploration of the theory of ""Fei and Dachang being interior-exteriorly related"" from observing changes of inflammatory cytokines and oxygen free radicals in the lung tissue of ulcerative colitis rats]."
|
24812904 |
2014 |
|
Chronic left-sided ulcerative colitis
|
0.200 |
Biomarker
|
disease |
RGD |
"[Exploration of the theory of ""Fei and Dachang being interior-exteriorly related"" from observing changes of inflammatory cytokines and oxygen free radicals in the lung tissue of ulcerative colitis rats]."
|
24812904 |
2014 |
|
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Abbreviations:</b> ATG16L1: autophagy-related 16-like 1 (S. cerevisiae); DAMP: damage-associated molecular pattern; HBSS: Hanks balanced salt solution; HMGB1: high mobility group box 1; IBD: inflammatory bowel disease; IL1B/Il-1β: interleukin 1 beta; IL10: interleukin 10; IL17/IL-17: interleukin 17; MEFs: mouse embryonic fibroblasts; STAT3: signal transducer and activator of transcription 3; TLR: toll-like receptor; TNF/TNF-α: tumor necrosis factor.
|
30894054 |
2019 |
|
Chronic arthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Calcium pyrophosphate (CPP) microcrystal deposition is associated with wide clinical phenotypes, including acute and chronic arthritis, that are interleukin 1β (IL-1β)-driven.
|
30356764 |
2018 |
|
Idiopathic generalized epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Neuroinflammation is an important feature of epileptogenesis.<b>Objectives:</b> To investigate the association of Interleukin-1beta-31 (IL-1β-31) and Interleukin-1 receptor antagonist (IL1-RA) genetic polymorphisms with idiopathic generalized epilepsy and demonstrate their influence on drug resistance in children.<b>Materials and Methods:</b> One hundred children with idiopathic generalized epilepsy were age and gender-matched with apparently healthy controls.
|
31698971 |
2020 |
|
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
<b>Background:</b> Using a secondary data analysis from randomized controlled trials comparing one year of resistance exercise (<i>n</i> = 109) to a placebo control condition (<i>n</i> = 106) in postmenopausal, posttreatment breast cancer survivors, we investigated the influence of resistance training and changes in body composition on markers associated with cancer progression.<b>Methods:</b> Measures included serum levels of insulin, IGF-1, IGFBP1-3, leptin, serum amyloid A (SAA), adiponectin, C-reactive protein (CRP), IL1β, TNFα, IL6, and IL8, and body composition (total, lean and fat mass in kg) by DXA at baseline, 6, and 12 months.
|
29141853 |
2018 |
|
Adult-Onset Still Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> This is the largest retrospective observational study evaluating the efficacy and safety of IL-1 inhibitors in AOSD patients.
|
28659802 |
2017 |
|
Chagas Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
<b>Conclusions:</b> We suggest some distinct molecular mechanisms for production of IL-1β in innate immune cells from patients with different clinical forms of Chagas disease.
|
31057540 |
2019 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
<b>Materials and Methods:</b> Healthy human colonic mucosal strips (4 × 10 mm) were incubated in carbogenated culture medium at 37°C for 16 h. Proinflammatory cytokines TNFα and IL-1β (each 10 ng/mL) were used to induce colitis in mucosal strips, and the effects of Panx1 and P2X7R on cytokines-induced tissue damage were determined in the presence of the Panx1 channel blocker <sup>10</sup>Panx1 (100 μM) and P2X7R antagonist A438079 (100 μM).
|
30127744 |
2018 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
<b>Results</b>: The <i>IL1B -5</i>11 C/T polymorphism was genotyped in 860 T2DM patients with or without DN and 505 healthy individuals.
|
31044637 |
2019 |
|
Dyspnea
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
<b>Results:</b> Compared with non-anticoagulation group, heparin pre-treatment (50 IU/100 g) delayed the onset of dyspnoea (<i>p</i> < 0.05), and showed a significant decrease in ND (<i>p</i> < 0.01), mortality rate (<i>p</i> < 0.05), HD (<i>p</i> < 0.01) and percentage of positive cells for TNF-α, IL-1β (<i>p</i> < 0.01) in cerebral ischaemia gerbils.
|
31401926 |
2019 |
|
Arteriosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> Our results indicated that the protein levels of HMGB1, TLR4, and pro-inflammatory cytokines including IL-1β, TNF-α were elevated with the development of atherosclerosis in CUMS mice, while the expressions of PPARγ, LXRα, and ABCA1 declined.
|
30881312 |
2019 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> Our results indicated that the protein levels of HMGB1, TLR4, and pro-inflammatory cytokines including IL-1β, TNF-α were elevated with the development of atherosclerosis in CUMS mice, while the expressions of PPARγ, LXRα, and ABCA1 declined.
|
30881312 |
2019 |
|
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> Our results showed that a proinflammatory cytokine interleukin-1β induced the OA model and desumoylation of aggrecan and collagen type II because the small ubiquitin-like modifier 2/3 (SUMO2/3) was co-localized with aggrecan and collagen type II proteins and interacted physically with them.
|
31372032 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> Plasma IL-1β levels were unmodified in SLE respect to HC whereas IL-6 levels were higher in SLE than in HC, resulting significantly increased in SLE-S. Macrophages isolated from SLE patients released lower quantities of IL-1β after stimulation with BzATP, whereas IL-6 release was significantly augmented in SLE-NS respect to both HC and SLE-S after all types of stimulation.
|
31110478 |
2019 |
|
Guillain-Barre Syndrome
|
0.050 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> The random-effects meta-analysis demonstrated that peripheral blood tumor necrosis factor-α (Hedges g, 1.544; 95% confidence interval (CI), 0.923-2.165; <i>p</i> < 0.001), interleukin-1β (IL-1β; Hedges g, 0.678; 95% CI, 0.183-1.172; <i>p</i> = 0.007), IL-6 (Hedges g, 0.630; 95% CI, 0.100-1.160; <i>p</i> = 0.02), IL-4 (Hedges g, 0.822; 95% CI, 0.220-1.423; <i>p</i> = 0.007), IL-17 (Hedges g, 1.452; 95% CI, 0.331-2.573; <i>p</i> = 0.011), interferon-γ (Hedges g, 1.104; 95% CI, 0.490-1.719; <i>p</i> < 0.001), and C-reactive protein (Hedges g, 0.909; 95% CI, 0.453-1.365; <i>p</i> < 0.001) levels were significantly increased in patients with GBS when compared with healthy controls.
|
31379477 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> The results of ELISA (IL-1β and tumor necrosis factor-α), the histological evaluation (Mankin and OARSI score), western blotting [COL2A1, matrix metalloproteinase (MMP)-3, MMP-13, IL-1β, and nuclear factor-kappaB (NF-κB) p65], and immunohistochemistry (COL2A1, MMP-3, and MMP-13) indicated that oral CAR attenuated the development of T2DM-induced OA and suppressed the inflammatory response.
|
29928231 |
2018 |
|
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> The results of ELISA (IL-1β and tumor necrosis factor-α), the histological evaluation (Mankin and OARSI score), western blotting [COL2A1, matrix metalloproteinase (MMP)-3, MMP-13, IL-1β, and nuclear factor-kappaB (NF-κB) p65], and immunohistochemistry (COL2A1, MMP-3, and MMP-13) indicated that oral CAR attenuated the development of T2DM-induced OA and suppressed the inflammatory response.
|
29928231 |
2018 |
|
Mycoplasma Infections
|
0.080 |
Biomarker
|
group |
BEFREE |
<i>Mycoplasma pneumoniae</i> is an atypical bacterial respiratory pathogen known to cause a range of airway inflammation and lung and extrapulmonary pathologies.We recently reported that an <i>M. pneumoniae</i>-derived ADP-ribosylating and vacuolating toxin called community-acquired respiratory distress syndrome (CARDS) toxin is capable of triggering NLRP3 (NLR-family, leucine-rich repeat protein 3) inflammasome activation and interleukin-1β (IL-1β) secretion in macrophages.
|
29061706 |
2018 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
<i>In vitro</i> experiments in rat macrophages showed that hyperglycemia treatment suppresses Nrf2 activation, resulting in oxidative stress with decreased expression of antioxidant genes, including NAD(P)H:quinone oxidoreductase 1 and heme oxygenase 1, together with increased secretion of proinflammatory cytokines, including interleukin 1β (IL1β), IL6, and monocyte chemoattractant protein-1.
|
31616304 |
2019 |
|
Mycoses
|
0.020 |
Biomarker
|
group |
BEFREE |
<i>In vitro</i> stimulation of whole blood samples with fungal antigen showed a highly amplified TNF and IL-1β response.
|
30873038 |
2019 |
|
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
<i>Results.</i> We found that IL-1ß cytokine is significantly higher in patients with PD (<i>p</i> value = 0.0014).
|
31205938 |
2019 |