Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that invasiveness of GBM cells is driven at least in part by aberrantly expressed IL-8.
|
20577780 |
2011 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Several human astrocytoma and glioblastoma cell lines expressed high levels of IL-8 and MCAF mRNA in vitro upon stimulation with IL-1 and TNF-alpha.
|
1937574 |
1991 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma.
|
20127012 |
2010 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We identified highly upregulated interleukin 8 (IL-8)-CXCR2 axis in tumor cells in high-grade human glioma and AAT-treated orthotopic GBM tumors.
|
30236892 |
2018 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results highlight a critical pro-angiogenic role of IL-8 in MES GBMs.
|
29644004 |
2018 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A glucocorticoid, dexamethasone, inhibited the production of a leukocyte chemotactic cytokine, interleukin 8 (IL-8), as well as mRNA expression by a glioblastoma cell line, T98G, stimulated with interleukin 1 (IL-1).
|
8175759 |
1994 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that bradykinin-induced IL-8 expression is dependent on B1R which causes phosphorylated STAT3 and acetylated SP-1 to translocate to the nucleus, hence resulting in GBM migration.
|
30366000 |
2019 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-17 stimulates the expression of IkappaB alpha mRNA and the secretion of IL-6 and IL-8 in glioblastoma cell lines.
|
10580807 |
1999 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Finally, in situ hybridization on glioblastoma sections shows that the in vivo expression patterns of IL-8 and VEGF genes overlap, but are not identical.
|
10050881 |
1999 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the role of chemokine IL-8 in glioblastoma progression with particular emphasis on immunomodulation, cellular proliferation, invasion and vascular mimicry.
|
30086759 |
2018 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Different types of cyto-chemokines are involved in the crosstalk between hAT-MSCs and BTICs (medulloblastoma and AT/RT: CXCR4/SDF-1, CCR5/RANTES, IL6R/IL-6 and IL8R/IL8; glioblastoma: CXCR4/SDF-1, IL6R/IL-6, IL8R/IL-8 and IGF1R/IGF-1).
|
26076490 |
2015 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here we report that IL-1β, IL-6, and IL-8 levels and p38 MAPK activity are elevated in human glioblastoma specimens and that p38 MAPK inhibitors attenuate the secretion of pro-inflammatory cytokines by microglia and glioblastoma cells.
|
22528800 |
2012 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells.
|
31440166 |
2019 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consistent with these results, IL8 is upregulated in PTEN-deficient human glioblastoma tumors.
|
18524891 |
2008 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since various external stimuli have been shown to increase intracellular Ca(2+) in glioma cells, we investigated Ca(2+) mobilization-dependent IL-8 expression and effect of cyclosporin A (CsA), an inhibitor of calcineurin (Cn), on the expression and invasive potential of human glioblastoma U251MG cells.
|
15286717 |
2004 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the results suggest that the recurrence of GBM is associated with high gene expression levels VEGFA and CXCL8, and the development of the central nervous system.
|
31788092 |
2019 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Using constitutively active HRasG12V that mimics enhanced Ras activation, we demonstrate that elevated Ras activity in glioblastoma cells leads to up-regulation of IL-6 and IL-8.
|
26794430 |
2016 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Blockade of IL-8 inhibited these effects in GBM-EC co-cultures, while IL-8 supplementation increased CSC-mediated growth and invasion in GBM-monocultures.
|
31227783 |
2019 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings suggest that NTS/IL-8/CXCR1/STAT3 signaling is crucial for the maintenance of stem-like traits in GSCs and provides a potential therapeutic target for glioblastoma therapy.
|
25200966 |
2014 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We showed that the human glioblastoma cell line U87 secreted considerable levels of IL-8 (CXCL8) upon stimulation by the FPR agonist peptide fMLF.
|
17611713 |
2008 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, IL-8 knockdown significantly delayed PDX GBM tumor growth in vivo (p < 0.0005).
|
30926789 |
2019 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma.
|
19668231 |
2009 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interestingly, IL-8, the main mediator regulating glioblastoma cell invasion, was suppressed in both transcriptional and protein level.
|
29412148 |
2018 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our results demonstrate the role of NF-kB as the mediator of bcl-xL-induced CXCL8 up-regulation in glioblastoma cells.
|
18786178 |
2008 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thus, in the present study, the effects of GBP and PGB on SP‑induced activation were investigated in the human glioblastoma astrocytoma U373 MG cell line, which expresses high levels of functional high‑affinity NK1R, and produces interleukin (IL)‑6 and IL‑8 in response to SP.
|
28849160 |
2017 |