Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Several human astrocytoma and glioblastoma cell lines expressed high levels of IL-8 and MCAF mRNA in vitro upon stimulation with IL-1 and TNF-alpha.
|
1937574 |
1991 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A glucocorticoid, dexamethasone, inhibited the production of a leukocyte chemotactic cytokine, interleukin 8 (IL-8), as well as mRNA expression by a glioblastoma cell line, T98G, stimulated with interleukin 1 (IL-1).
|
8175759 |
1994 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hypoxic/anoxic insults on glioblastoma cells in vitro using anaerobic chamber systems or within spheroids developing central necrosis induced an increase in IL-8 messenger RNA (mRNA) and protein expression. mRNA for IL-8-binding chemokine receptors CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC) were found in all astrocytoma grades by reverse transcription/PCR analysis.
|
9334359 |
1997 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-17 stimulates the expression of IkappaB alpha mRNA and the secretion of IL-6 and IL-8 in glioblastoma cell lines.
|
10580807 |
1999 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Finally, in situ hybridization on glioblastoma sections shows that the in vivo expression patterns of IL-8 and VEGF genes overlap, but are not identical.
|
10050881 |
1999 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since various external stimuli have been shown to increase intracellular Ca(2+) in glioma cells, we investigated Ca(2+) mobilization-dependent IL-8 expression and effect of cyclosporin A (CsA), an inhibitor of calcineurin (Cn), on the expression and invasive potential of human glioblastoma U251MG cells.
|
15286717 |
2004 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines.
|
16356833 |
2006 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness.
|
18524891 |
2008 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consistent with these results, IL8 is upregulated in PTEN-deficient human glioblastoma tumors.
|
18524891 |
2008 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
We recently reported that bcl-xL regulates interleukin 8 (CXCL8) protein expression and promoter activity in glioblastoma cells.
|
18786178 |
2008 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We showed that the human glioblastoma cell line U87 secreted considerable levels of IL-8 (CXCL8) upon stimulation by the FPR agonist peptide fMLF.
|
17611713 |
2008 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our results demonstrate the role of NF-kB as the mediator of bcl-xL-induced CXCL8 up-regulation in glioblastoma cells.
|
18786178 |
2008 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma.
|
19668231 |
2009 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma.
|
20127012 |
2010 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to analyze the methylation status of four critical tumor-associated genes (MGMT, RARbeta, RASSF1A, CDH13), and investigate possible links with inflammatory (interleukin [IL]-6, IL-8) and angiogenic mediators (vascular endothelial growth factor [VEGF], cyclooxygenase [COX]-2) and clinical outcome in 23 glioma samples (6 grade II astrocytomas, 17 grade IV glioblastomas).
|
19809523 |
2010 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that invasiveness of GBM cells is driven at least in part by aberrantly expressed IL-8.
|
20577780 |
2011 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Conversely, enforced expression of CypA in the CypA KD cell line, Ud-12, markedly enhanced IL-8 transcripts and restored Ud-12 proliferation, suggesting that CypA-mediated IL-8 production provides a growth advantage to glioblastoma cells.
|
20454998 |
2011 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here we report that IL-1β, IL-6, and IL-8 levels and p38 MAPK activity are elevated in human glioblastoma specimens and that p38 MAPK inhibitors attenuate the secretion of pro-inflammatory cytokines by microglia and glioblastoma cells.
|
22528800 |
2012 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings suggest that NTS/IL-8/CXCR1/STAT3 signaling is crucial for the maintenance of stem-like traits in GSCs and provides a potential therapeutic target for glioblastoma therapy.
|
25200966 |
2014 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Different types of cyto-chemokines are involved in the crosstalk between hAT-MSCs and BTICs (medulloblastoma and AT/RT: CXCR4/SDF-1, CCR5/RANTES, IL6R/IL-6 and IL8R/IL8; glioblastoma: CXCR4/SDF-1, IL6R/IL-6, IL8R/IL-8 and IGF1R/IGF-1).
|
26076490 |
2015 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Using constitutively active HRasG12V that mimics enhanced Ras activation, we demonstrate that elevated Ras activity in glioblastoma cells leads to up-regulation of IL-6 and IL-8.
|
26794430 |
2016 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thus, in the present study, the effects of GBP and PGB on SP‑induced activation were investigated in the human glioblastoma astrocytoma U373 MG cell line, which expresses high levels of functional high‑affinity NK1R, and produces interleukin (IL)‑6 and IL‑8 in response to SP.
|
28849160 |
2017 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We identified highly upregulated interleukin 8 (IL-8)-CXCR2 axis in tumor cells in high-grade human glioma and AAT-treated orthotopic GBM tumors.
|
30236892 |
2018 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results highlight a critical pro-angiogenic role of IL-8 in MES GBMs.
|
29644004 |
2018 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the role of chemokine IL-8 in glioblastoma progression with particular emphasis on immunomodulation, cellular proliferation, invasion and vascular mimicry.
|
30086759 |
2018 |