|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Behçet's disease (BD) is an immune-mediated and complex disease which has been associated with HLA class I molecules although other genes such as IL23R and IL10 have also been involved in the susceptibility to BD.
|
26005883 |
2016 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Behçet's disease (BD) susceptibility had been associated with single-nucleotide polymorphisms (SNPs) in IL23R-IL12RB2, IL10, STAT4, or ERAP1 locus in Japanese, Turkish, Chinese, and other populations, but not in a Korean genome-wide association study (GWAS).
|
29017598 |
2017 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
IL10 may be the susceptibility gene for BD in Chinese Han population.
|
24269690 |
2014 |
|
Behcet Syndrome
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population.
|
26015771 |
2015 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population.
|
26015771 |
2015 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Although we were not able to formally replicate the association with IL10 and IL23R-IL12RB2, we do report that BD in Iran is strongly associated with HLA-B*51, MICA-A6, and the three HLA-linked SNPs (odds ratio (OR) = 3.38, P = 6.21 × 10(-14); OR = 2.08, P = 1.58 × 10(-13); and OR = 1.67-4.05, P = 1.45 × 10(-04) to 4.79 × 10(-34), respectively).
|
25940109 |
2015 |
|
Behcet Syndrome
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, a positive correlation was observed between IL-10 serum levels and ocular manifestations in BD patients, in contrast to those of IL-17, showing no correlation with the different clinical manifestations.
|
31122907 |
2019 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
|
23291587 |
2013 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
CTD_human |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
Behcet Syndrome
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
HBV: hepatitis B virus; HCC hepatocellular carcinoma; TNFSF10: tumor necrosis factor superfamily member 10; ATG5: autophagy-related protein 5; DNA: deoxyribonucleic acid; LDR-PCR: ligase detection reactions-polymerase chain reaction; PCR: polymerase chain reaction; SLE: systemic lupus erythematosus; BD: Behçet's disease; IL-10: interlukin-10; LPS: lipopolysaccharide; PBMC: peripheral blood mononuclear cells; CWP: coal workers' pneumoconiosis; TNF-α: tumor necrosis factor-α.
|
30907204 |
2019 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In IL10, rs1518111 was nominally associated with BD before and after adjustment for population stratification (odds ratio [OR] for T allele 1.20, 95% confidence interval [95% CI] 1.02-1.40, unadjusted P [P(unadj) ] = 2.53 × 10(-2) ; adjusted P [P(adj) ] = 1.43 × 10(-2) ), and rs1554286 demonstrated a trend toward association (P(unadj) = 6.14 × 10(-2) ; P(adj) = 3.21 × 10(-2) ).
|
22378604 |
2012 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the current study of Behçet disease (BD), nonsynonymous variants (NSVs) identified by deep exonic resequencing of 10 genes found by GWAS (IL10, IL23R, CCR1, STAT4, KLRK1, KLRC1, KLRC2, KLRC3, KLRC4, and ERAP1) and 11 genes selected for their role in innate immunity (IL1B, IL1R1, IL1RN, NLRP3, MEFV, TNFRSF1A, PSTPIP1, CASP1, PYCARD, NOD2, and TLR4) were evaluated for BD association.
|
23633568 |
2013 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Non-HLA genetic associations such as endoplasmic reticulum aminopeptidase 1 (ERAP1), interleukin 23 receptor (IL23R) and IL10 variations suggest that BD shares susceptibility genes and inflammatory pathways with spondyloarthritis.
|
26068404 |
2015 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our aim was to fully examine the relationship between IL-10 and BD, the associations between BD and single nucleotide polymorphisms (SNPs) in IL-10-mediated signalling pathways (JAK1, TYK2, and STAT3) were examined in Korean patients with BD.
|
24428981 |
2014 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese.
|
27464962 |
2017 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates that functional TNF-α, IL10 genotypes or combined TNF-α, IL10 genotypes do not play a role in BS susceptibility in Turkish BS patients.
|
20191386 |
2010 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in interleukin-10, IL-8 and CD28 genes were also associated with Behçet's disease.
|
18281862 |
2008 |