|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Rare IL10 coding variants were not detected in BD patients, but we identified 28 known single nucleotide polymorphisms with minor allele frequencies ranging from 0.010 to 0.390, and five novel non-coding variants in five heterozygous cases. ss836185595, located in the IL10 3' untranslated region, was also detected in one Iranian control individual and therefore is not specific to BD.
|
24708170 |
2017 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Regarding the non-HLA genes, the three SNPs located in IL23R and one of the SNPs in IL10 were found to be significantly associated with susceptibility to BD in our population.
|
24286189 |
2013 |
|
Behcet Syndrome
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Revealing the key molecular mechanism by which IL-10 expression is regulated is crucial to understanding the pathogenesis of BD.
|
29096751 |
2017 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
The IL10 SNPs did not segregate with BD and KD suggesting that there was no association between the IL10 gene and these diseases in this family.
|
22749664 |
2013 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The evaluation of the IL-2 gene polymorphism (p=0.0065) and IL-10 gene polymorphism (p=0.0483) distributions with respect to age of BD onset revealed a statistically significant distribution.
|
26654556 |
2016 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The objective of the present study was to clarify the pathological roles of CCR1 and IL10 loci identified by previous BD genome-wide association studies (GWASs).
|
29895319 |
2018 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The present study might suggest that TNF-α -308A/G, IL-10 -1082G/A, -819C/T, -592C/A polymorphisms are associated with BD susceptibility.
|
24267724 |
2013 |
|
Behcet Syndrome
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The proinflammatory cytokines versus IL-10 ratios were significantly higher in BD compared with other groups.
|
21334264 |
2011 |
|
Behcet Syndrome
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The same difference was observed in IL-10 levels in culture supernatant after T. Baseline TLR4 expression was significantly higher in BD patients compared to healthy donors (HC).
|
27467286 |
2016 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the goal of this study was to measure the correlation of the IL-10 gene polymorphisms with the susceptibility to Behçet's disease compared with the control group in the Azeri population and to determine the expression of this gene in the two groups.
|
29294320 |
2018 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that TGF-Beta1 and IL-10 gene polymorphisms may affect host susceptibility to BD.
|
19796538 |
2010 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
This link between BD, a chronic, relapsing, autoinflammatory condition, and a genotype associated with low IL-10 production provides evidence that abnormalities in the genetic control of cytokine levels may be relevant in influencing the immune response in Behçet's disease in some patient groups.
|
17321902 |
2007 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD.
|
26213801 |
2015 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis showed that the IL-10 - 819 C/T and - 592 C/A polymorphisms are associated with BD susceptibility, especially in Asian population.
|
31721090 |
2019 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Three risk loci shared with ankylosing spondylitis and psoriasis (the MHC class I region, ERAP1 and IL23R and the MHC class I-ERAP1 interaction), as well as two loci shared with inflammatory bowel disease (IL23R and IL10) implicate shared pathogenic pathways in the spondyloarthritides and Behçet's disease.
|
23291587 |
2013 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Thus, this study aimed to investigate the associations between IL-6 and IL-10 promoter single-nucleotide polymorphisms (SNPs) and the susceptibility to BD and their implication on plasma levels.
|
24703990 |
2014 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Treg and Th17 cell frequencies and Th17 RORγt expression were significantly elevated, and IL-10 concentration in Treg cell supernatants was significantly lower in BD patients than in controls.
|
30601931 |
2019 |
|
Behcet Syndrome
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We revealed that hypermethylation of promoter region was the principal defect for the IL-10 mRNA low expression in patients with Behçet's disease.
|
29719061 |
2018 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
We tested 14 single-nucleotide polymorphisms (SNPs) in 13 genomic loci (excluding the major histocompatibility complex [MHC], IL10, and IL23R-IL12RB2, which have already been associated with BD in Iranians) for allelic and genotypic associations with BD in 973 patients and 828 controls from Iran and performed meta-analyses of the significantly associated markers.
|
26097239 |
2015 |