|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found an association between the SNP LTA +252 with the development of sepsis [OR 1.29 (1.00-1.68)]; the SNP IL10 -1082 with sepsis severity [OR 0.53 (0.29-0.97)]; the TNF -308 with mortality [OR 0.33 (0.12-0.95)]; and the IL10 -592 and IL10 -1082 with admission to the intensive care unit (ICU) [OR 3.36 (1.57-7.18)] and [OR 0.18 (0.04-0.86)], respectively.
|
27592234 |
2016 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis.
|
16859504 |
2006 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The objectives of this prospective study were to investigate the distribution of IL-10 promoter polymorphisms in a cohort of 308 Chinese Han patients with major trauma, and to identify associations of IL-10 promoter polymorphisms with IL-10 production and incidence of sepsis and MODS.
|
19939284 |
2009 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Distribution of TNF-α(308) genotypes is associated with outcome, IL-10(1082) with type of microorganism and underlying cause of sepsis, and CD14(159) with type of microorganism.
|
20163933 |
2010 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These and other research data clearly demonstrated that the -1082 A/G polymorphism in the IL-10 gene promoter has an important impact on susceptibility of sepsis and sepsis outcome.
|
20236506 |
2010 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Therefore, polymorphisms within the IL-10 gene may be predictors of outcome in patients with sepsis from pneumonia.
|
16162776 |
2005 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients.
|
20835611 |
2010 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We sought to determine whether there was an association between IL-6, IL-10 and IL-17 polymorphisms with cytokine production and development of sepsis.
|
22079540 |
2012 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We conclude allelic variations in PLA2G2A, TLR2, TLR5, and IL10 may moderate the predisposition to sepsis in preterm infants.
|
20463618 |
2010 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This work attempts to further quantitatively assess the association of three widely evaluated polymorphisms of IL-10 (-592C/A, -819C/T, -1082A/G) with sepsis susceptibility through a meta-analysis.
|
25497741 |
2015 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The A allele of the -1082 polymorphism in the interleukin-10 gene promoter is associated with sepsis susceptibility, whereas G allele is associated with higher stimulated interleukin-10 production and increased mortality in severe sepsis.
|
16435103 |
2006 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study may indicate that TNF-alpha-308G/A and IL-10-592C/A polymorphisms involved in subsequent activation of cytokine network had a larger effect on clinical outcome in patients with sepsis than TLR4Asp299Gly, Thr399Ile, and CD14-159C/T polymorphisms associated with the initial host-microbial interaction.
|
16051275 |
2005 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
<b>Conclusion</b> We uncovered an association between IL-10 1082 gene variation and sepsis in VLBW infants but did not identify associations between neonatal sepsis and TNF-α 308 or IL-6 gene variation.
|
27960200 |
2017 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The variants of IL-10 -1082 A allele and IL-6 -174 C allele contributed to an increased risk of pneumonia-induced sepsis.
|
27388228 |
2017 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Interleukin-10 haplotype associated with increased mortality in critically ill patients with sepsis from pneumonia but not in patients with extrapulmonary sepsis.
|
16162776 |
2005 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Patients with IL-10 (-1082A/A) genotypes were found significantly higher in post traumatic sepsis patients and had a significantly higher risk to developed sepsis complication (p < 0.05, OR = 0.86, C.I = 0.08-8.8).In case of TNF-α (-308) position, GA and GG genotype patients have a significantly lower risk of poor outcome (p < 0.05, OR = 0.25, C.I = 0.01-1.3) and (p < 0.05, OR = 0.22, C.I = 0.01-0.5) in comparison to AA genotype.
|
26561011 |
2015 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Surviving sepsis patients had a significant decrease of IL-10-1082 allele G frequency, compared with controls (17% vs 47.2%; p=0.012).
|
16435103 |
2006 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Further studies are needed to investigate the effect of IL-10-1082A/G polymorphism on sepsis susceptibility in Caucasians.
|
23716201 |
2013 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Considering combinations of genotypes, the TNF-alpha high and IL-10 low producer genotype combination was associated with a approximately 6-fold increased risk of death compared to the TNF-alpha-low and IL-10 intermediate/high producer genotype combination, after adjustment for either APACHE II (P=0.004), MOF score (P=0.004) or sepsis (P=0.006).
|
15036247 |
2004 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigate whether interleukin-10 (IL-10)-1082 G/G genotype is associated with the mortality rate of acute respiratory distress syndrome (ARDS) in a hospital-based case-control study in China conducted on 314 patients with ARDS and 210 controls admitted to an intensive care unit for sepsis, trauma, aspiration, or massive transfusions.
|
21138342 |
2011 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Circulating concentrations of CRP, PCT, interleukin (IL)-10 and IL-1 receptor antagonist (IL-1Ra) were significantly higher in patients with sepsis, with IL-10 identified as the best biomarker in differentiating sepsis from SIRS.
|
31125901 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
RAGE-Mediated Suppression of Interleukin-10 Results in Enhanced Mortality in a Murine Model of Acinetobacter baumannii Sepsis.
|
28052995 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Blockade of IL-10R by Ab or genetic deficiency of IL-10 resulted in 3-5-fold higher concentrations of IL-27(p28) in endotoxic shock and polymicrobial sepsis.
|
25348624 |
2014 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results demonstrate the advantageous role of de novo IL-10 synthesis in early stages of sepsis and suggest the beneficial impact of gene transfer approach to recombinant protein infusions.
|
16783196 |
2006 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Makino, or C. longa L. in control or sepsis groups in this study, only the influence of IL-10 was consistent in both control and sepsis groups.
|
29462699 |
2018 |