Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
<b>Conclusion</b> We uncovered an association between IL-10 1082 gene variation and sepsis in VLBW infants but did not identify associations between neonatal sepsis and TNF-α 308 or IL-6 gene variation.
|
27960200 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Sepsis increased plasma interleukin-6 (IL-6) and IL-10 and clonidine further increased IL-10 (1.6 ± 0.1 to 3.3 ± 0.7 ng/mL), but not IL-6.Clonidine reduced rectal temperature.
|
29489737 |
2019 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Interleukin-10 (IL-10) is an anti-inflammatory cytokine and levels have been shown to be highest in those patients who develop sepsis after trauma or surgery.
|
12925485 |
2003 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
A Cox proportional hazards model focussed on the acute phase showed that the above combined score was significantly related with patient prognosis, suggesting that the cytokine network of IL-6, IL-8, MCP-1 and IL-10 could play a pivotal role in the acute phase of sepsis.
|
30228372 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
A total of 120 consecutive Chinese patients with sepsis were prospectively included, and serum levels of FGF21 and biomarkers such as interleukin (IL)-6, tumor necrosis factor alpha (TNF-α), IL-10, procalcitonin (PCT), C-reactive protein (CRP), and lactate (LAC) were measured within 24 h after intensive care unit admission.
|
29861384 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adenoviral delivery of human and viral IL-10 in murine sepsis.
|
11441115 |
2001 |
Sepsis
|
0.600 |
Therapeutic
|
disease |
CTD_human |
Adenoviral delivery of human and viral IL-10 in murine sepsis.
|
11441115 |
2001 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
After adjustment for shock and sepsis status at admission, CD74 and IL10 levels were found to be significantly associated with IAI occurrence [subdistribution hazard ratio (95% confidence interval) 0.67 (0.46-0.97) for CD74 D3/D1 expression ratio and 2.21 (1.63-3.00) for IL10 at D3].
|
28477143 |
2017 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Altogether, AT treatment improved survival, increased IL-10 levels, and mitigated a pro-inflammatory response during sepsis.
|
30897322 |
2019 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because of B-1a cell loss, Cmtm7-deficient mice produced less IgM and IL-10, and were more susceptible to microbial sepsis.
|
31081901 |
2019 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Blockade of IL-10R by Ab or genetic deficiency of IL-10 resulted in 3-5-fold higher concentrations of IL-27(p28) in endotoxic shock and polymicrobial sepsis.
|
25348624 |
2014 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
CD19<sup>+</sup>CD11b<sup>+</sup>CD5<sup>+</sup> B1a regulatory cells were shown to rapidly express IL-10 in a TLR2-dependent manner in response to <i>S. aureus</i>, and adoptive transfer of B1a cells was protective during acute systemic infection in IL-10-deficient hosts.
|
28167629 |
2017 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Circulating IL-10 levels increased significantly after 12 h in the sepsis groups compared with sham animals, while that of the NT and HT groups were comparable.
|
29505782 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Circulating concentrations of CRP, PCT, interleukin (IL)-10 and IL-1 receptor antagonist (IL-1Ra) were significantly higher in patients with sepsis, with IL-10 identified as the best biomarker in differentiating sepsis from SIRS.
|
31125901 |
2019 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
CMV is reactivated in sepsis and these patients presented a higher risk of developing septic shock and higher mortality rates and our data suggest that IL-10 and NO may be involved in this process.
|
31227794 |
2019 |
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Considering combinations of genotypes, the TNF-alpha high and IL-10 low producer genotype combination was associated with a approximately 6-fold increased risk of death compared to the TNF-alpha-low and IL-10 intermediate/high producer genotype combination, after adjustment for either APACHE II (P=0.004), MOF score (P=0.004) or sepsis (P=0.006).
|
15036247 |
2004 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cytokine levels were higher in patients with sepsis vs. controls (interleukin [IL]-10, blisters: 65.9 vs. 4.3 pg/ml, P < 0.001, serum: 25.7 vs. 4.5 pg/ml, P = 0.004; IL-6, blisters: 41.9 vs. 0.03 pg/ml, P < 0.001, serum: 45.5 vs. 2.1 pg/ml, P < 0.001).
|
27514616 |
2017 |
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Distribution of TNF-α(308) genotypes is associated with outcome, IL-10(1082) with type of microorganism and underlying cause of sepsis, and CD14(159) with type of microorganism.
|
20163933 |
2010 |
Sepsis
|
0.600 |
Therapeutic
|
disease |
RGD |
Effects of Pseudomonas aeruginosa mannose-sensitive hemagglutinin (PA-MSHA) pretreatment on septic rats.
|
24055021 |
2013 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Finally, to provide additional potential clinical relevance, we examined the effect of IL-10 on T cell IFN-γ production in an in vivo cecal ligation and puncture model of sepsis using C57 black/J6 female mice.
|
31501258 |
2019 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Following CASP, Dusp1(-/-) mice had increased serum levels of CCL4, interleukin-10 (IL-10) and IL-6, with differences from wild-type mice being dependent on severity of sepsis.
|
20561086 |
2010 |
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Further studies are needed to investigate the effect of IL-10-1082A/G polymorphism on sepsis susceptibility in Caucasians.
|
23716201 |
2013 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we demonstrated that IL-10 reduction of T-cell functionality was associated with increased FOXP3 expression in CD4<sup>+</sup>CD25<sup>+</sup>CD127<sup>-</sup> regulatory T cells as observed in sepsis.
|
29182416 |
2018 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrate that omega-9 treatment is associated with increased levels of the anti-inflammatory cytokine IL-10 and decreased levels of the proinflammatory cytokines TNF-<i>α</i> and IL-1<i>β</i> in peritoneal lavage fluid of mice with sepsis.
|
30538802 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-38 administration decreased the inflammatory response, as reflected by lower levels of cytokines and chemokines (including IL-6, TNF-α, interleukin 10, interleukin 17, interleukin 27, CXCL1, and CCL2), and less damage to tissues (including lung, liver, and kidney) in CLP-induced sepsis.
|
29762676 |
2018 |