|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interleukin 8 production in whole blood assays: Is interleukin 10 responsible for the downregulation observed in sepsis?
|
10623443 |
2000 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Specifically, we review the role of IL-10 in human endotoxemia/sepsis and in HIV infection, conditions for which preliminary phase I trials have recently been undertaken.
|
11197608 |
2000 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adenoviral delivery of human and viral IL-10 in murine sepsis.
|
11441115 |
2001 |
|
Sepsis
|
0.600 |
Therapeutic
|
disease |
CTD_human |
Adenoviral delivery of human and viral IL-10 in murine sepsis.
|
11441115 |
2001 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We report here that inhibition of thymocyte apoptosis by targeted adenovirus-induced thymic expression of human IL-10 reduced blood bacteremia and prevented mortality in sepsis.
|
11553765 |
2001 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells.
|
11907099 |
2002 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We subjected IL-10-deficient (IL-10(-/-)) and wild-type (IL-10(+/+)) mice to CLP and monitored the progression of sepsis, the onset of irreversible shock, and mortality.
|
12117955 |
2002 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, in the patients who developed sepsis, interleukin-10 release at admission to the intensive care unit was significantly lower than in patients who did not subsequently develop sepsis (median [range] 1.47 [0.13-6.90] ng/mL compared with 4.93 [0.03-16.80] ng/mL, p = .001).
|
12544990 |
2003 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Interleukin-10 (IL-10) is an anti-inflammatory cytokine and levels have been shown to be highest in those patients who develop sepsis after trauma or surgery.
|
12925485 |
2003 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Other candidate genes for sepsis and septic shock include the interleukin (IL)-1 receptor antagonist gene, the heat shock protein gene, the IL-6 gene, the IL-10 gene, the CD-14 gene, the Toll-like receptor (TLR)-4 gene, and the TLR-2 gene, to name a few.
|
12970043 |
2003 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Considering combinations of genotypes, the TNF-alpha high and IL-10 low producer genotype combination was associated with a approximately 6-fold increased risk of death compared to the TNF-alpha-low and IL-10 intermediate/high producer genotype combination, after adjustment for either APACHE II (P=0.004), MOF score (P=0.004) or sepsis (P=0.006).
|
15036247 |
2004 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study may indicate that TNF-alpha-308G/A and IL-10-592C/A polymorphisms involved in subsequent activation of cytokine network had a larger effect on clinical outcome in patients with sepsis than TLR4Asp299Gly, Thr399Ile, and CD14-159C/T polymorphisms associated with the initial host-microbial interaction.
|
16051275 |
2005 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Therefore, polymorphisms within the IL-10 gene may be predictors of outcome in patients with sepsis from pneumonia.
|
16162776 |
2005 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Interleukin-10 haplotype associated with increased mortality in critically ill patients with sepsis from pneumonia but not in patients with extrapulmonary sepsis.
|
16162776 |
2005 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The A allele of the -1082 polymorphism in the interleukin-10 gene promoter is associated with sepsis susceptibility, whereas G allele is associated with higher stimulated interleukin-10 production and increased mortality in severe sepsis.
|
16435103 |
2006 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Surviving sepsis patients had a significant decrease of IL-10-1082 allele G frequency, compared with controls (17% vs 47.2%; p=0.012).
|
16435103 |
2006 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results demonstrate the advantageous role of de novo IL-10 synthesis in early stages of sepsis and suggest the beneficial impact of gene transfer approach to recombinant protein infusions.
|
16783196 |
2006 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis.
|
16859504 |
2006 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the seven HCMV-positive patients with positive IL-10 levels in BAL only, HCMV persisted in BAL for a median of 579 days without signs of systemic infection (positive plasma levels) or clinical symptoms.
|
17667821 |
2007 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have previously shown that intrathymic delivery of IL-10 with an adenoviral vector in wild-type mice significantly improves outcome to sepsis.
|
18959626 |
2008 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
RGD |
Paeoniflorin inhibits systemic inflammation and improves survival in experimental sepsis.
|
19371254 |
2009 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The objectives of this prospective study were to investigate the distribution of IL-10 promoter polymorphisms in a cohort of 308 Chinese Han patients with major trauma, and to identify associations of IL-10 promoter polymorphisms with IL-10 production and incidence of sepsis and MODS.
|
19939284 |
2009 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Distribution of TNF-α(308) genotypes is associated with outcome, IL-10(1082) with type of microorganism and underlying cause of sepsis, and CD14(159) with type of microorganism.
|
20163933 |
2010 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of IL-1beta/-1470, IL-1beta/-511, IL-1beta/-31, IL-4/-589, IL-6/-572, IL-8/-251, IL-10/-819, and TNFalpha/-308 are susceptibility loci for the development of sepsis and organ dysfunction in major trauma patients.
|
20217044 |
2010 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These and other research data clearly demonstrated that the -1082 A/G polymorphism in the IL-10 gene promoter has an important impact on susceptibility of sepsis and sepsis outcome.
|
20236506 |
2010 |