Squamous cell carcinoma of the head and neck
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Squamous cell carcinoma of the head and neck
|
0.710 |
Biomarker
|
disease |
CTD_human |
|
|
|
Squamous cell carcinoma of the head and neck
|
0.710 |
CausalMutation
|
disease |
CGI |
|
|
|
Squamous cell carcinoma
|
0.160 |
Biomarker
|
disease |
HPO |
|
|
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The BARF1-transformed cells and the tumour tissues isolated from new-born rats after injection of such transformed cell both express p33.
|
2555151 |
1989 |
Chronic granulomatous disease
|
0.020 |
AlteredExpression
|
group |
BEFREE |
This observation suggests that patients with CGD may also have a defect in lymphocyte function. p47 protein and mRNA levels increase during retinoic acid-induced neutrophil differentiation of HL60 cells.
|
2398896 |
1990 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results demonstrate that ING1 can act as a potent growth regulator in normal and in established cells and provide evidence for a role as a candidate tumour suppressor gene whose inactivation may contribute to the development of cancers.
|
8944021 |
1996 |
Malignant neoplasm of breast
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Limited analyses of tumour cell lines show that mutation of the ING1 gene occurs in neuroblastoma cells and reduced expression was seen in some breast cancer cell lines.
|
8944021 |
1996 |
Breast Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Limited analyses of tumour cell lines show that mutation of the ING1 gene occurs in neuroblastoma cells and reduced expression was seen in some breast cancer cell lines.
|
8944021 |
1996 |
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Limited analyses of tumour cell lines show that mutation of the ING1 gene occurs in neuroblastoma cells and reduced expression was seen in some breast cancer cell lines.
|
8944021 |
1996 |
Central neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Limited analyses of tumour cell lines show that mutation of the ING1 gene occurs in neuroblastoma cells and reduced expression was seen in some breast cancer cell lines.
|
8944021 |
1996 |
Childhood Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Limited analyses of tumour cell lines show that mutation of the ING1 gene occurs in neuroblastoma cells and reduced expression was seen in some breast cancer cell lines.
|
8944021 |
1996 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both ING1 and ING1L are expressed in a variety of human tissues, but we found ING1L expression to be significantly more pronounced in tumors from several colon-cancer patients than in normal colon tissues excised at the same surgical sites.
|
10072587 |
1998 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Although the significance of this observation with respect to carcinogenesis remains to be established, the data suggest that ING1L might be involved in colon cancers through interference with signal(s) transmitted through p53 and p33(ING1).
|
10072587 |
1998 |
Malignant neoplasm of breast
|
0.090 |
Biomarker
|
disease |
BEFREE |
The ING1 gene encodes p33(ING1), a putative tumor suppressor for neuroblastomas and breast cancers, which has been shown to cooperate with p53 in controlling cell proliferation.
|
10072587 |
1998 |
Neuroblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The ING1 gene encodes p33(ING1), a putative tumor suppressor for neuroblastomas and breast cancers, which has been shown to cooperate with p53 in controlling cell proliferation.
|
10072587 |
1998 |
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although the significance of this observation with respect to carcinogenesis remains to be established, the data suggest that ING1L might be involved in colon cancers through interference with signal(s) transmitted through p53 and p33(ING1).
|
10072587 |
1998 |
Malignant neoplasm of stomach
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
A significant decrease in p33(ING1) expression was evident in 15 of 20 gastric cancers.
|
10660101 |
1999 |
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Decreased expression of p33ING1 mRNA in lymphoid malignancies.
|
10577281 |
1999 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings are interpreted to mean that p33(ING1) may function as a tumor suppressor in gastric carcinogenesis, even though the gene is preserved in the majority of gastrointestinal carcinomas.
|
10660101 |
1999 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The ING1 is a newly cloned putative tumor-suppressor gene, which is involved in the p53 signaling pathway.
|
10577281 |
1999 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, ING1 mutation is very rare in breast or ovarian cancers, however, repression of ING1 expression frequently accompanies tumour development of breast cancer.
|
10498868 |
1999 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our findings are interpreted to mean that p33(ING1) may function as a tumor suppressor in gastric carcinogenesis, even though the gene is preserved in the majority of gastrointestinal carcinomas.
|
10660101 |
1999 |
Malignant neoplasm of breast
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Thus, ING1 mutation is very rare in breast or ovarian cancers, however, repression of ING1 expression frequently accompanies tumour development of breast cancer.
|
10498868 |
1999 |
Malignant neoplasm of breast
|
0.090 |
Biomarker
|
disease |
BEFREE |
Furthermore, a novel gene, designated as ING2, sharing 76% nucleotide homology with ING1 was identified in the breast cancer cDNA library.
|
10626813 |
1999 |