ING1, inhibitor of growth family member 1, 3621

N. diseases: 99; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Squamous cell carcinoma of the head and neck
0.710 GeneticVariation disease UNIPROT Of 34 informative cases of head and neck squamous cell carcinoma, 68% of tumors showed loss of heterozygosity at chromosome 13q33-34, where the ING1 gene is located. 10866301 2000
Squamous cell carcinoma of the head and neck
0.710 Biomarker disease BEFREE Because ING1 resides on the long arm of chromosome 13 (13q34) (a region frequently deleted in many tumor types), we sought to characterize its role in head and neck squamous-cell carcinoma (HNSCC). 10679922 2000
Squamous cell carcinoma of the head and neck
0.710 CausalMutation disease CLINVAR
Squamous cell carcinoma of the head and neck
0.710 Biomarker disease CTD_human
Squamous cell carcinoma of the head and neck
0.710 CausalMutation disease CGI
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.320 Biomarker disease CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753 2011
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.320 AlteredExpression disease BEFREE However, there has been no report on the prognostic significance of the ING1 expression level in human cancers, though the expression of the wild-type ING1 gene is significantly decreased in breast, lymphoid and gastric cancers as compared with their corresponding normal tissues. 15375504 2004
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.320 AlteredExpression disease BEFREE A significant decrease in p33(ING1) expression was evident in 15 of 20 gastric cancers. 10660101 1999
CUI: C0011616
Disease: Contact Dermatitis
Contact Dermatitis
0.300 Biomarker disease CTD_human Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay. 25724174 2015
CUI: C0162351
Disease: Contact hypersensitivity
Contact hypersensitivity
0.300 Biomarker phenotype CTD_human Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay. 25724174 2015
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.300 Biomarker group CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753 2011
CUI: C0235874
Disease: Disease Exacerbation
Disease Exacerbation
0.300 Biomarker phenotype CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753 2011
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.300 Biomarker disease CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753 2011
CUI: C0280302
Disease: Squamous cell carcinoma of lip
Squamous cell carcinoma of lip
0.300 SomaticCausalMutation disease ORPHANET Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. 10866301 2000
Squamous cell carcinoma of oropharynx
0.300 SomaticCausalMutation disease ORPHANET Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. 10866301 2000
Squamous cell carcinoma of the hypopharynx
0.300 SomaticCausalMutation disease ORPHANET Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. 10866301 2000
CUI: C0280324
Disease: Laryngeal Squamous Cell Carcinoma
Laryngeal Squamous Cell Carcinoma
0.300 SomaticCausalMutation disease ORPHANET Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. 10866301 2000
CUI: C0585362
Disease: Squamous cell carcinoma of mouth
Squamous cell carcinoma of mouth
0.300 SomaticCausalMutation disease ORPHANET Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. 10866301 2000
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.160 Biomarker disease BEFREE Nuclear entrapment of p33ING1b by inhibition of exportin-1: A trigger of apoptosis in head and neck squamous cell cancer. 29729696 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.160 Biomarker disease LHGDN Nuclear to cytoplasmic shift of p33(ING1b) protein from normal oral mucosa to oral squamous cell carcinoma in relation to clinicopathological variables. 17805569 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.160 AlteredExpression disease BEFREE GAPDH mRNA expression was detectable in 12 out of 21 oral squamous cell carcinoma (SCC) samples. p21WAF1 mRNA expression was detectable in 5 out of 12 SCC samples, MDM2 mRNA expression was detectable in 5 our of 12 SCC samples and p33ING1 mRNA expression was detectable in 6 out of 12 SCC samples. 12926130 2003
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.160 AlteredExpression disease BEFREE Twenty-six of 28 oral squamous cell carcinomas (SCCs) expressed p33ING1 mRNA. 12063558 2002
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.160 Biomarker disease BEFREE Mutational analysis of the candidate tumor suppressor gene ING1 in Indian oral squamous cell carcinoma. 11287275 2001
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.160 GeneticVariation disease BEFREE Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. 10866301 2000
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.160 Biomarker disease HPO