|
Ovarian papillary adenocarcinoma
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Elevated carcinoembryonic antigen level
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Elevated carcinoma antigen 125 level
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Urinary Urgency, CTCAE 5
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Malignant neoplasm of stomach
|
0.050 |
Biomarker
|
disease |
BEFREE |
On the basis of the observations and findings of this study, INHBA gene silencing inhibited the progression of GC by inactivating the TGF-β signaling pathway, which provides a potential target in the treatment of GC.
|
30963572 |
2019 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
On the basis of the observations and findings of this study, INHBA gene silencing inhibited the progression of GC by inactivating the TGF-β signaling pathway, which provides a potential target in the treatment of GC.
|
30963572 |
2019 |
|
Malignant neoplasm of stomach
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
INHBA gene expression in gastric cancer tissue is considered a useful independent predictor of outcomes in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1.
|
28652421 |
2018 |
|
Stomach Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
INHBA gene expression in gastric cancer tissue is considered a useful independent predictor of outcomes in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1.
|
28652421 |
2018 |
|
Malignant neoplasm of stomach
|
0.050 |
Biomarker
|
disease |
BEFREE |
Overexpression of the INHBA gene is considered a useful independent predictor of outcomes in patients with gastric cancer after curative surgery.
|
24778035 |
2014 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Overexpression of the INHBA gene is considered a useful independent predictor of outcomes in patients with gastric cancer after curative surgery.
|
24778035 |
2014 |
|
Malignant neoplasm of stomach
|
0.050 |
Biomarker
|
disease |
BEFREE |
The 8 genes are composed of down-regulated KLF4, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA in gastric cancer.
|
20043075 |
2010 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The 8 genes are composed of down-regulated KLF4, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA in gastric cancer.
|
20043075 |
2010 |
|
Malignant neoplasm of stomach
|
0.050 |
Biomarker
|
disease |
BEFREE |
When a representative predictor set of 92 genes was examined, pathways of 'focal adhesion' (with gene components of THBS2, PDGFD, MAPK1, COL1A2, COL6A3), 'ECM-receptor interaction' pathway (THBS2, COL1A2, COL6A3, FN1) and 'TGF-beta signaling' (THBS2, MAPK1, INHBA) represent some of the main differences between normal and tumor of gastric cancer at a molecular level.
|
17601708 |
2007 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
When a representative predictor set of 92 genes was examined, pathways of 'focal adhesion' (with gene components of THBS2, PDGFD, MAPK1, COL1A2, COL6A3), 'ECM-receptor interaction' pathway (THBS2, COL1A2, COL6A3, FN1) and 'TGF-beta signaling' (THBS2, MAPK1, INHBA) represent some of the main differences between normal and tumor of gastric cancer at a molecular level.
|
17601708 |
2007 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
In addition, knockdown of INHBA in cancer cells impaired cancer xenograft growth through reducing OC stromal fibroblast activation <i>in vivo.</i> Further results confirmed that Smad2 signaling pathway was involved in INHBA-induced stromal fibroblast activation, and inhibiting this pathway could effectively reverse activation of stromal fibroblasts.
|
31827640 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
In addition, knockdown of INHBA in cancer cells impaired cancer xenograft growth through reducing OC stromal fibroblast activation <i>in vivo.</i> Further results confirmed that Smad2 signaling pathway was involved in INHBA-induced stromal fibroblast activation, and inhibiting this pathway could effectively reverse activation of stromal fibroblasts.
|
31827640 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
INHBA, which encodes a member of the TGF-beta superfamily of proteins, has been identified to play a critical role in different types of cancer.
|
29950896 |
2018 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
INHBA, which encodes a member of the TGF-beta superfamily of proteins, has been identified to play a critical role in different types of cancer.
|
29950896 |
2018 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Relative INHBA gene expression was measured in surgical specimens of cancer tissue and adjacent normal mucosa by quantitative real-time, reverse-transcription polymerase chain reaction.
|
24778035 |
2014 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Relative INHBA gene expression was measured in surgical specimens of cancer tissue and adjacent normal mucosa by quantitative real-time, reverse-transcription polymerase chain reaction.
|
24778035 |
2014 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In some cancer cell lines, the gene encoding activin A (inhibin βA [INHBA]) is over-expressed and enhances cancer proliferation.
|
20926007 |
2010 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In some cancer cell lines, the gene encoding activin A (inhibin βA [INHBA]) is over-expressed and enhances cancer proliferation.
|
20926007 |
2010 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Thus, this study intends to investigate the effects of inhibin βA (INHBA) gene silencing on the migration and invasion of GC cells via the transforming growth factor-β (TGF-β) signaling pathway.
|
30963572 |
2019 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Mesometrial tissues from seropositive dams were analyzed for expression of interleukin 1β, 6, and 10, TNF, TGF-β, follistatin-related protein 3, and inhibin beta A chain since these genes regulate extravillous trophoblast invasion.
|
29788108 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
The expression level of TGFB/INHBA and other invasion-associated genes was measured by quantitative-PCR (Q-PCR) and Western Blot after transfection/treatments with clones/reagents in normal/cancer cells.
|
26298390 |
2015 |