|
Polycystic Ovary Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Expression of FSHR (P < 0.05), AR (P < 0.05), and CYP11A1 (P < 0.05) was lower, and expression of CYP19A1 (P < 0.05), STAR (P < 0.05), HSD3B2 (P = NS), and INHBA (P < 0.05) was higher in PCO GCs.
|
31276164 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Of these genes, INHBA, a TGF-β ligand found mutated in lung adenocarcinoma, showed reduced expression in BMICs with knockdown of SPOCK1.
|
28766011 |
2017 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In stage I AD patients, high levels of primary tumor INHBA transcripts were associated with worse prognosis.
|
19308293 |
2009 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Primary ADs expressed 3.1 times more INHBA mRNA than normal lung.
|
19308293 |
2009 |
|
Polycystic Ovary Syndrome
|
0.020 |
Biomarker
|
disease |
LHGDN |
High serum concentration of total inhibin in polycystic ovary syndrome.
|
18423626 |
2008 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In clinical samples, ANLN and INHBA showed a significantly higher expression in tumors than in normal tissues.
|
17982635 |
2007 |
|
Rheumatoid Arthritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis.
|
16735027 |
2006 |
|
Degenerative polyarthritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis.
|
16735027 |
2006 |
|
Rheumatoid Arthritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
However, there was no difference between these groups in the amount of synovial FRP, suggesting its elevated turnover in RA.
|
9786430 |
1998 |
|
Degenerative polyarthritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
FRP gene expression was higher in RA than OA synovium (P < 0.05).
|
9786430 |
1998 |
|
Fibrosis, Liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The TRIB3-mediated autophagy impairment not only suppressed autophagic degradation of late endosomes but also promoted hepatocellular secretion of INHBA/Activin A-enriched exosomes which caused migration, proliferation and activation of hepatic stellate cells (HSCs), the effector cells of liver fibrosis.
|
31286822 |
2020 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that SPP1, VIP, COL11A1, CA2, ADAM12, INHBA could provide great significant prognostic value for colon cancer.
|
30746900 |
2019 |
|
Noninfiltrating Intraductal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results indicate that ID2 is a key driver of DCIS formation and therefore is considered to be a potential target for prevention of DCIS, while INHBA and GJB2 play vital roles in progression of DCIS to IDC and they may serve as potential prognosis markers.
|
30725231 |
2019 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The unique presence of serpin A3-7, coiled-coil domain containing 88A and inhibin/activin β A chain in HR-EXO, indicates potential biomarkers for cows at-risk for metabolic diseases.
|
31554846 |
2019 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that SPP1, VIP, COL11A1, CA2, ADAM12, INHBA could provide great significant prognostic value for colon cancer.
|
30746900 |
2019 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, knockdown of INHBA in cancer cells impaired cancer xenograft growth through reducing OC stromal fibroblast activation <i>in vivo.</i> Further results confirmed that Smad2 signaling pathway was involved in INHBA-induced stromal fibroblast activation, and inhibiting this pathway could effectively reverse activation of stromal fibroblasts.
|
31827640 |
2019 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, knockdown of INHBA in cancer cells impaired cancer xenograft growth through reducing OC stromal fibroblast activation <i>in vivo.</i> Further results confirmed that Smad2 signaling pathway was involved in INHBA-induced stromal fibroblast activation, and inhibiting this pathway could effectively reverse activation of stromal fibroblasts.
|
31827640 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, knockdown of INHBA in cancer cells impaired cancer xenograft growth through reducing OC stromal fibroblast activation <i>in vivo.</i> Further results confirmed that Smad2 signaling pathway was involved in INHBA-induced stromal fibroblast activation, and inhibiting this pathway could effectively reverse activation of stromal fibroblasts.
|
31827640 |
2019 |
|
Asthma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The activity of CU was assessed by European Academy of Allergology and Clinical Immunology; Global Allergy and Asthma European Network; European Dermatology Forum (EAACI/GA2LEN/EDF) activity score.
|
29694255 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Kaplan-Meier analysis showed that ESCC patients in the low INHBA expression subgroup had significantly better prognosis than those with high INHBA level.
|
29950896 |
2018 |
|
Solid Neoplasm
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
What is more, we conducted a meta-analysis to study the prognostic value of INHBA expression in multiple types of solid tumors.
|
29950896 |
2018 |
|
melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By using primary melanoma cell lines, as well as commercially available melanoma cell lines, we find that the evaluation of MLANA and INHBA expression is as capable as one based on a combined analysis performed with genes for stemness, EMT and invasion/proliferation, in identifying melanoma subtypes that differ in their sensitivity to molecularly targeted drugs.
|
28670440 |
2017 |
|
Cachexia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The bodyweights of mice inoculated with INHBA-overexpressed cells decreased dramatically, and these mice all died at an early stage, suggesting the occurrence of activin-induced cachexia.
|
25449777 |
2015 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our work demonstrates that INHBA mRNA and protein expression are commonly elevated in primary human NSCLC and provide evidence that INHBA is a critical autocrine factor that maintains mesenchymal properties of CICs to promote metastasis in NSCLC.
|
25432175 |
2015 |
|
Carcinoma, Transitional Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
INHBA protein overexpression was significantly associated with advanced clinicopathological features in both groups of UC.
|
25488476 |
2015 |