IRF1, interferon regulatory factor 1, 3659

N. diseases: 257; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0392164
Disease: Pulmonary Cystic Fibrosis
Pulmonary Cystic Fibrosis 		0.010 Biomarker disease BEFREE These results add a new element, the S/MAR, that can be considered to improve the persistence and safety of gene therapy vectors for cystic fibrosis pulmonary disease. 29673202 2018
CUI: C0392557
Disease: Nuclear cataract
Nuclear cataract 		0.010 Biomarker disease BEFREE Presence of nuclear cataract was defined when the log MAR visual acuity with correction was greater than or equal to 0.2 and one or more of the following were met: Pentacam Nuclear Staging (PNS) grading score ≥ 1, average value of nuclear density ≥ 15%, maximum value of nuclear density ≥ 30%. 30305075 2018
CUI: C1112705
Disease: Nuclear non-senile cataract
Nuclear non-senile cataract 		0.010 Biomarker disease BEFREE Presence of nuclear cataract was defined when the log MAR visual acuity with correction was greater than or equal to 0.2 and one or more of the following were met: Pentacam Nuclear Staging (PNS) grading score ≥ 1, average value of nuclear density ≥ 15%, maximum value of nuclear density ≥ 30%. 30305075 2018
CUI: C1264610
Disease: Infectious peritonitis
Infectious peritonitis 		0.010 AlteredExpression disease BEFREE Finally, the antiviral activity of IRF1 against feline panleukopenia virus, feline herpesvirus, and feline infectious peritonitis virus was demonstrated. 30009167 2018
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.010 AlteredExpression disease BEFREE Mechanistically, we found that metformin depressed YAP promoter by competing with the binding of the transcription factor IRF-1 in lung cancer cells. 30389502 2018
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.010 Biomarker disease BEFREE The generation of MAR-ASD-specific epitope autoantibodies in female mice prior to breeding created a model that demonstrates for the first time that ASD-specific antigen-induced maternal autoantibodies produced alterations in a constellation of ASD-relevant behaviors. 29955164 2018
CUI: C2062441
Disease: Influenza A
Influenza A 		0.010 Biomarker disease BEFREE Overall, our study identified IRF1 as an upstream regulator of NLRP3 inflammasome and cell death during IAV infection and further highlights the complex and multilayered regulation of key molecules controlling inflammatory response and cell fate decisions during infections. 29321274 2018
CUI: C3805043
Disease: Vascular cognitive impairment
Vascular cognitive impairment 		0.010 Biomarker disease BEFREE Therefore, we assessed the effect of IRF-1 on cognitive function using a vascular cognitive impairment mouse model created by chronic cerebral hypoperfusion. 30082820 2018
CUI: C0003864
Disease: Arthritis
Arthritis 		0.010 AlteredExpression disease BEFREE We conclude that pristane enhanced autophagy, leading to a STAT1-IRF1 controlled upregulation of TLR3 expression in macrophages, is a pathogenic mechanism in the development of arthritis. 27940139 2017
CUI: C0011311
Disease: Dengue Fever
Dengue Fever 		0.010 Biomarker disease BEFREE These results reveal a key antiviral role for IRF-1 by activating both type I and II IFN responses during DENV infection. 29117564 2017
CUI: C0014057
Disease: Japanese Encephalitis
Japanese Encephalitis 		0.010 Biomarker disease BEFREE The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection. 28196914 2017
CUI: C0019100
Disease: Severe Dengue
Severe Dengue 		0.010 Biomarker disease BEFREE The former are enriched in binding sites for STAT1, STAT2, and IRF1, which are associated with DHF-promoting antibody-dependent enhancement, whereas the latter are considered to be related to the dysfunction of spliceosomes, which may mediate haemorrhage. 28276456 2017
CUI: C0021053
Disease: Immune System Diseases
Immune System Diseases 		0.010 Biomarker group BEFREE These data reveal broad cooperation between STAT1 and IRF1, explain cell type specific differences in ISG-responsiveness, and identify genetic variants that may participate in the pathogenesis of immune disorders. 28274199 2017
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.010 AlteredExpression group BEFREE Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease. 28416283 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.010 Biomarker disease BEFREE This highlights IRF1's relevance to obesity-related inflammation and the resultant metabolic dysregulation. 28416283 2017
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.010 GeneticVariation disease BEFREE The IRF1, SUMO1P1 and KRR1 loci may confer PCOS risk in development. 28068351 2017
CUI: C0036690
Disease: Septicemia
Septicemia 		0.010 AlteredExpression disease BEFREE Although the exact mechanisms responsible for sepsis-induced mitochondrial damage are unknown, the nuclear transcription factor, interferon regulatory factor-1 (IRF-1) has been reported to cause mitochondrial damage in several diseases. 28849179 2017
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.010 Biomarker disease BEFREE To examine genetic defects of the IFNγ-IRF1 pathway in non-small cell lung cancer (NSCLC), we analyzed The Cancer Genome Atlas (TCGA) lung adenocarcinoma (LuAd) and lung squamous cell carcinoma (LuSc) data. 28977839 2017
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.010 Biomarker disease BEFREE To examine genetic defects of the IFNγ-IRF1 pathway in non-small cell lung cancer (NSCLC), we analyzed The Cancer Genome Atlas (TCGA) lung adenocarcinoma (LuAd) and lung squamous cell carcinoma (LuSc) data. 28977839 2017
CUI: C0243026
Disease: Sepsis
Sepsis 		0.010 AlteredExpression disease BEFREE Although the exact mechanisms responsible for sepsis-induced mitochondrial damage are unknown, the nuclear transcription factor, interferon regulatory factor-1 (IRF-1) has been reported to cause mitochondrial damage in several diseases. 28849179 2017
CUI: C0278883
Disease: Metastatic melanoma
Metastatic melanoma 		0.010 AlteredExpression disease BEFREE Nuclear IRF-1 expression as a mechanism to assess "Capability" to express PD-L1 and response to PD-1 therapy in metastatic melanoma. 28331615 2017
CUI: C0339434
Disease: Choroidal effusion
Choroidal effusion 		0.010 Biomarker disease BEFREE The median log MAR VA improved from 0.77 (range, 0.3 to 2) preoperatively to 0.44 (range, 0 to 3) postoperatively (P=0.27).Four patients had postoperatory surgical complications: choroidal effusion (2), vitreous hemorrhage and hyphema (1), vertical diplopia (1). 28671924 2017
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.010 AlteredExpression disease BEFREE Hyperactive mTOR induces neuroendocrine differentiation in prostate cancer cell with concurrent up-regulation of IRF1. 28905415 2017
CUI: C0574002
Disease: Edema of foot (finding)
Edema of foot (finding) 		0.010 AlteredExpression phenotype BEFREE IRF-1 expression limited CHIKV-induced foot swelling in joint-associated tissues and prevented dissemination of CHIKV and RRV at early time points. 28835505 2017
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.010 AlteredExpression disease BEFREE Hyperactive mTOR induces neuroendocrine differentiation in prostate cancer cell with concurrent up-regulation of IRF1. 28905415 2017