IRF1, interferon regulatory factor 1, 3659

N. diseases: 257; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0677932
Disease: Progressive Neoplastic Disease
Progressive Neoplastic Disease 		0.010 AlteredExpression phenotype BEFREE Nuclear IRF-1 expression was higher in patients with partial or complete response (PR/CR) than in patients with stable or progressive disease (SD/PD) (<i>p =</i> 0.044). 28331615 2017
CUI: C0729531
Disease: Viral respiratory infection
Viral respiratory infection 		0.010 Biomarker group BEFREE Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition. 28581456 2017
CUI: C0751079
Disease: Diplopia, Vertical
Diplopia, Vertical 		0.010 Biomarker disease BEFREE The median log MAR VA improved from 0.77 (range, 0.3 to 2) preoperatively to 0.44 (range, 0 to 3) postoperatively (P=0.27).Four patients had postoperatory surgical complications: choroidal effusion (2), vitreous hemorrhage and hyphema (1), vertical diplopia (1). 28671924 2017
CUI: C3539781
Disease: Progressive cGVHD
Progressive cGVHD 		0.010 AlteredExpression disease BEFREE Nuclear IRF-1 expression was higher in patients with partial or complete response (PR/CR) than in patients with stable or progressive disease (SD/PD) (<i>p =</i> 0.044). 28331615 2017
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.010 GeneticVariation disease BEFREE We further show that in ALS brain tissue, neuronal ERVK reactivation is associated with the nuclear translocation of IRF1 and NF-κB isoforms p50 and p65. 27512062 2016
CUI: C0018081
Disease: Gonorrhea
Gonorrhea 		0.010 Biomarker disease BEFREE In this study, we focus on the miRNA-associated single nucleotide polymorphisms (SNPs) in the 3'untranslated region (UTR) of IRF-1 to further investigate the functional relationship and potential diagnostic value of the SNPs and miRNAs among Chinese gastric cancer (GC) patients. 27866197 2016
CUI: C0238339
Disease: Hereditary pancreatitis
Hereditary pancreatitis 		0.010 AlteredExpression disease BEFREE Carrying the G genotype was related to significantly low expression of IRF-1 and Hp infection, poor differentiation, big tumor size, invasion depth, as well as the high probability of metastasis, and moreover, the C/G SNP was associated with shorter survival of GC patients with five years of follow-up study. 27866197 2016
CUI: C0333983
Disease: Hyperplastic Polyp
Hyperplastic Polyp 		0.010 AlteredExpression disease BEFREE Carrying the G genotype was related to significantly low expression of IRF-1 and Hp infection, poor differentiation, big tumor size, invasion depth, as well as the high probability of metastasis, and moreover, the C/G SNP was associated with shorter survival of GC patients with five years of follow-up study. 27866197 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.010 Biomarker disease BEFREE These data suggest that IRF1 may regulate bevacizumab-induced autophagy, and may be one important mediator of glioblastoma resistant to bevacizumab. 26362401 2015
CUI: C0017638
Disease: Glioma
Glioma 		0.010 Biomarker disease BEFREE Consistently, IRF1 depletion increased the efficacy of anti-VEGF therapy in a glioma xenograft model, which was due to less bevacizumab-promoted autophagy and increased apoptosis in tumors with down-regulated IRF1. 26362401 2015
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.010 Biomarker group BEFREE Gene expression meta-analysis reveals immune response convergence on the IFNγ-STAT1-IRF1 axis and adaptive immune resistance mechanisms in lymphoma. 26362649 2015
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms 		0.010 Biomarker group BEFREE These studies define a novel mechanism associated with skin tumor promotion by the anthrone class of tumor promoters involving upregulation of IFNγ signaling in the epidermis and downstream signaling through activated (phosphorylated) Stat1, IRF-1 and uStat1. 24464587 2015
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.010 Biomarker disease BEFREE These data suggest that IRF1 may regulate bevacizumab-induced autophagy, and may be one important mediator of glioblastoma resistant to bevacizumab. 26362401 2015
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.010 Biomarker disease BEFREE These data suggest that IRF1 may regulate bevacizumab-induced autophagy, and may be one important mediator of glioblastoma resistant to bevacizumab. 26362401 2015
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma 		0.010 Biomarker disease BEFREE Gene expression meta-analysis reveals immune response convergence on the IFNγ-STAT1-IRF1 axis and adaptive immune resistance mechanisms in lymphoma. 26362649 2015
CUI: C1332979
Disease: Childhood Lymphoma
Childhood Lymphoma 		0.010 Biomarker disease BEFREE Gene expression meta-analysis reveals immune response convergence on the IFNγ-STAT1-IRF1 axis and adaptive immune resistance mechanisms in lymphoma. 26362649 2015
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.010 Biomarker disease BEFREE These data suggest that IRF1 may regulate bevacizumab-induced autophagy, and may be one important mediator of glioblastoma resistant to bevacizumab. 26362401 2015
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.010 AlteredExpression disease BEFREE We examined the relative mRNA and protein expression of IRF-1 in human monocyte-derived DCs in patients with coronary artery disease (CAD). 25997853 2015
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.010 AlteredExpression disease BEFREE Additionally, IRF1 was correlated with high-sensitivity C-reactive protein, erythrocyte sedimentation rate, Crohn's disease activity index, Crohn's disease endoscopic index of severity, and simple endoscopic score for Crohn's disease in Crohn's disease and with high-sensitivity C-reactive protein, erythrocyte sedimentation rate, Mayo score, Baron score, modified Baron score, Rachmilewitz score, ulcerative colitis endoscopic index of severity, ulcerative colitis colonoscopic index of severity, and disease duration in ulcerative colitis. 25208103 2014
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.010 AlteredExpression group BEFREE IRF1 was upregulated in human IBD and in the colon epithelium of mice with dextran sulfate sodium-induced colitis. 25208103 2014
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma 		0.010 Biomarker disease BEFREE Interferon regulatory factor 1 is an independent predictor of platinum resistance and survival in high-grade serous ovarian carcinoma. 24995581 2014
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.010 PosttranslationalModification disease BEFREE We investigated whether IRF1 and IRF2 are involved in the progression of pancreatic cancer. 24632547 2014
CUI: C0340279
Disease: Ventricular hypertrophy
Ventricular hypertrophy 		0.010 AlteredExpression disease BEFREE Transgenic mice with cardiac-specific IRF1 overexpression exacerbated aortic banding-induced cardiac hypertrophy, ventricular dilation, fibrosis, and dysfunction, whereas IRF1-deficient (knockout) mice exhibited a significant reduction in the hypertrophic response. 24732887 2014
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.010 PosttranslationalModification disease BEFREE We investigated whether IRF1 and IRF2 are involved in the progression of pancreatic cancer. 24632547 2014
CUI: C0936223
Disease: Metastatic Prostate Carcinoma
Metastatic Prostate Carcinoma 		0.010 AlteredExpression disease BEFREE DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. 24886089 2014