|
Hypertension, Diastolic, Resistance to
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Elevated diastolic blood pressure
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Ventricular Fibrillation, Paroxysmal Familial, 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It is suggested that coexpression of hbeta(1) exposes a more severe functional defect that results in a greater overlap in the relationship between channel inactivation and activation (window current) in T1620M, which is proposed to be a potential pathophysiological mechanism of IVF in vivo.
|
10618304 |
2000 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
RGD |
Downregulation of the BK channel beta1 subunit in genetic hypertension.
|
14551242 |
2003 |
|
Anoxia
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
Post-transcriptional control of human maxiK potassium channel activity and acute oxygen sensitivity by chronic hypoxia.
|
14522958 |
2003 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Current transients associated with BK channels in human glioma cells.
|
12962281 |
2003 |
|
Diastolic hypertension
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension.
|
15057310 |
2004 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
BEFREE |
Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita Study.
|
15671602 |
2005 |
|
Diastolic hypertension
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk.
|
16293791 |
2005 |
|
Diastolic hypertension
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
A recent study reported a new polymorphism (E65 K) in the beta(1) subunit (KCNMB1) gene of the Ca(2+)-dependent potassium channel with a protective effect against the severity of diastolic hypertension, but further data have lead to conflicting results.
|
16155733 |
2005 |
|
Coronary Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients.
|
16155733 |
2005 |
|
Myocardial Ischemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients.
|
16155733 |
2005 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
RGD |
Altered expression of BK channel beta1 subunit in vascular tissues from spontaneously hypertensive rats.
|
16814121 |
2006 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
CTD_human |
KCNMB1 is involved in calcium sensitivity and hypertension.
|
17700361 |
2007 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
BEFREE |
KCNMB1 is involved in calcium sensitivity and hypertension.
|
17700361 |
2007 |
|
Hypertensive disease
|
0.550 |
GeneticVariation
|
group |
BEFREE |
We also found that the carriers of minor T allele of KCNMB1-rs11739136 had a significantly decreased risk for hypertension (TT+CT vs. CC; odds ratio=0.83; 95% confidence interval, 0.72-0.95; P value after the Bonferroni correction=0.008 x 5=0.040).
|
18496125 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
RGD |
Impaired Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats.
|
18790848 |
2008 |
|
Diastolic hypertension
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The rs11739136 KCNMB1 Glu65Lys polymorphism in the beta1 subunit of the Ca2+ and voltage-dependent potassium channel has, in some studies, been reported to associate with a protective effect on diastolic hypertension.
|
18854753 |
2008 |
|
Airway Obstruction
|
0.010 |
GeneticVariation
|
group |
LHGDN |
An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity.
|
18535015 |
2008 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
The C818T SNP and four other KCNMB1 variants were genotyped in two independent groups of African American asthmatics (n = 509) and tested for association with the pulmonary function measure--forced expiratory volume (FEV(1)) % of predicted value.
|
18535015 |
2008 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The C818T SNP and four other KCNMB1 variants were genotyped in two independent groups of African American asthmatics (n = 509) and tested for association with the pulmonary function measure--forced expiratory volume (FEV(1)) % of predicted value.
|
18535015 |
2008 |
|
Hypertensive disease
|
0.550 |
AlteredExpression
|
group |
LHGDN |
Maxi-K+ channel beta1 expression in sleep apnea patients and its modulation by CPAP treatment.
|
19057512 |
2009 |
|
Sleep Apnea, Obstructive
|
0.010 |
Biomarker
|
disease |
LHGDN |
Maxi-K+ channel beta1 expression in sleep apnea patients and its modulation by CPAP treatment.
|
19057512 |
2009 |
|
Hypertensive disease
|
0.550 |
GeneticVariation
|
group |
BEFREE |
KCNMB1 gain-of-function variant Glu65Lys results in generalized vasorelaxation and thus protection against systemic hypertension.
|
20861615 |
2010 |
|
Kidney Failure
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Common KCNMB1 gain-of-function variant Glu65Lys influences GFR, and 65Lys carriers exhibit not only elevated baseline GFR, but also more rapid GFR decline (and consequent development of renal failure) in CKD.
|
20861615 |
2010 |