Common KCNMB1 gain-of-function variant Glu65Lys influences GFR, and 65Lys carriers exhibit not only elevated baseline GFR, but also more rapid GFR decline (and consequent development of renal failure) in CKD.
Genotype and allele frequency analyses revealed that the frequency of genotypes KCNJ11-rs2285676 and KCNMB1-rs11739136 was not significantly different between the EH and NT groups.
These results demonstrate that GAS infection preferentially induces ineffective LAP to evade xenophagic killing in endothelial cells through the SLO/β1 integrin/NOX2/ROS pathway.<b>IMPORTANCE</b> Our previous reports showed that the LC3-associated GAS-containing single membrane vacuoles are inefficient for bacterial clearance in endothelial cells, which may result in bacteremia.
Additionally, overexpression of miR-29b in normal PASMC decreased large-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> (BK<sub>Ca</sub>) channel currents and downregulated BK<sub>Ca</sub> channel β1 subunit (BK<sub>Ca</sub>β1 or KCNMB1) expression, while inhibition of miR-29b in IPAH-PASMC increased BK<sub>Ca</sub> channel activity and BK<sub>Ca</sub>β1 levels.