|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
When administered to beta-arrestin 2 knockout mice, lithium fails to affect Akt/GSK3 signaling and induce behavioral changes associated with GSK3 inhibition as it does in normal animals.
|
18191226 |
2008 |
|
Acute pancreatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
β-Arr1 but not β-arr2 is significantly downregulated in caerulein-induced AP in mice.
|
30144357 |
2019 |
|
Addictive Behavior
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
These data support targeting GHSR1a signaling in addiction therapy but indicate that using signaling biased compounds that modulate βarrestin-2 activity differentially from G protein activity may be required.
|
28941296 |
2018 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Further evaluations indicated that phospho-Stat3, phospho-Akt, phospho-nuclear factor κB, cyclin D1, and Ki67 were upregulated in adenocarcinomas from ARR(2)Pb.Stat3C x PTEN(+/-) mice.
|
21390188 |
2011 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We performed IHC on tissue microarrays from two cohorts of lung cancer patients to analyse the expression of beta-arrestin-1, beta-arrestin-2 and clinically used diagnostic markers in ADC and SCC samples.
|
30078843 |
2018 |
|
Adrenoleukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our data suggested that Arrb2 may serve as a potential therapeutic target for ALD by promoting hepatocyte apoptosis via Akt suppression.
|
30283336 |
2018 |
|
Adult Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that the xenograft tumor initiated earlier and grew more rapidly in beta-Arr1 transgenic mice than in both the beta-Arr2 transgenic and wild-type mice after inoculating murine liver cancer Hepa1-6 cells or lymphoma EL4 cells.
|
17890288 |
2008 |
|
Agnosia for Pain
|
0.020 |
Biomarker
|
disease |
BEFREE |
Intrathecal injection of the mu-opioid receptor agonist [D-Ala(2), NMe-Phe(4), Gly-ol(5)]-enkephalin produces paradoxical behavioural responses: early-phase analgesia and late-phase mechanical allodynia which requires NMDAR; both phases are prolonged in Arrb2 knockout (KO) mice.
|
27538456 |
2016 |
|
Agnosia for Pain
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Ventral striatal-specific increases in KOR levels and KOR-induced G protein activation are seen in RGS12-null mice, as well as enhanced sensitivity to KOR agonist-induced hypolocomotion and analgesia-G protein signaling-dependent behaviors; a ventral striatal-specific increase in KOR levels was also observed in β-arrestin-2-deficient mice, highlighting the importance of β-arrestin signaling to establishing steady-state KOR levels in this particular brain region.
|
31141817 |
2019 |
|
airway disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Methods to Investigate the Roles for β-Arrestin-2 in Allergic Inflammatory Airway Disease.
|
30919364 |
2019 |
|
Alcoholic Liver Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
β-Arrestin 2 Promotes Hepatocyte Apoptosis by Inhibiting Akt Pathway in Alcoholic Liver Disease.
|
30283336 |
2018 |
|
Alzheimer Disease, Late Onset
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genetic variation of ARRB2 is associated with late-onset Alzheimer's disease in Han Chinese.
|
24635845 |
2014 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Emerging evidence indicates that β-arrestin 2, an important regulator of G protein coupled receptors, is involved in the pathogenesis of Alzheimer's disease (AD).
|
24635845 |
2014 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, these studies identify β-arrestin 2 as a new therapeutic target for reducing amyloid pathology and GPCR dysfunction in Alzheimer's disease.
|
23202293 |
2013 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Although expression of both ARRB1 and ARRB2 was reduced in serum from patients with AD, the levels of ARRB1 were much lower than those of ARRB2 in AD.
|
28611418 |
2017 |
|
Amphetamine Abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia.
|
17233643 |
2007 |
|
Amphetamine Addiction
|
0.300 |
Biomarker
|
disease |
CTD_human |
Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia.
|
17233643 |
2007 |
|
Amphetamine-Related Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia.
|
17233643 |
2007 |
|
Aortic Valve Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
MAPK kinase family, β-arrestin-2, Akt, and Ca<sup>2+</sup>-related signaling pathways were markedly activated in TAC but mildly upregulated or unchanged in AR.
|
29196344 |
2018 |
|
Arteriovenous fistula
|
0.200 |
Biomarker
|
phenotype |
RGD |
Gender related alterations of β-adrenoceptor mechanisms in heart failure due to arteriovenous fistula.
|
22015551 |
2012 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To examine the in vivo role of β-arrestin 2 in the pathogenesis of arthritis, WT and β-arrestin 2 KO mice were subjected to collagen antibody-induced arthritis (CAIA).
|
21855149 |
2011 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings point to a proinflammatory role for β-arr2-dependent signaling and support β-arr2 as a novel therapeutic target in asthma.
|
29361236 |
2018 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
β-arrestin (ARRB2) is a member of arrestin family and a negative regulatory protein of G-coupling receptor, which is closely associated with the pathogenesis of several autoimmune diseases.
|
29272019 |
2017 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Taken together, our study identified β-arrestin 2 as a new regulator of DC migration and immune properties, providing new insights into the mechanisms underlying the development of autoimmune disease.
|
30541881 |
2019 |
|
Bacteremia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study describes molecular mechanisms of antimicrobial resistance in an isolate from bacteraemia investigated through whole genome sequencing. bla<sub>NDM-7</sub> was found on IncA/C2 plasmid which also carried sul-1, aadA2, rmtC, bla<sub>CMY-6</sub> and ARR-2. ompK35 had mutations and changes from 39th amino acid. ompK36 was truncated to 248 amino acids.The isolate belonged to ST147.
|
31003835 |
2020 |