|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia.
|
19049562 |
2008 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
We therefore conducted a genetic case-control association analysis of the gene for ARRB2 with schizophrenia and METH use disorder in a Japanese population (547 people with schizophrenia, 177 with METH use disorder and 546 controls).
|
17233643 |
2007 |
|
Cocaine Dependence
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Association study of the β-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population.
|
22472784 |
2012 |
|
Mood Disorders
|
0.310 |
Biomarker
|
group |
PSYGENET |
Deficient beta-arrestin-2-CRF(1) receptor interactions could contribute to the pathophysiology of affective disorders by inducing excessive CRF(1) receptor signaling.
|
17363685 |
2007 |
|
Mood Disorders
|
0.310 |
Biomarker
|
group |
BEFREE |
Deficient beta-arrestin-2-CRF(1) receptor interactions could contribute to the pathophysiology of affective disorders by inducing excessive CRF(1) receptor signaling.
|
17363685 |
2007 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Bipolar Disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Here we show that lithium, a pharmacological agent used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling and related behaviors in mice by disrupting a signaling complex composed of Akt, beta-arrestin 2, and protein phosphatase 2A.
|
18191226 |
2008 |
|
Mental Depression
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Here we show that lithium, a pharmacological agent used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling and related behaviors in mice by disrupting a signaling complex composed of Akt, beta-arrestin 2, and protein phosphatase 2A.
|
18191226 |
2008 |
|
Depressive disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Here we show that lithium, a pharmacological agent used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling and related behaviors in mice by disrupting a signaling complex composed of Akt, beta-arrestin 2, and protein phosphatase 2A.
|
18191226 |
2008 |
|
Amphetamine-Related Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia.
|
17233643 |
2007 |
|
Amphetamine Addiction
|
0.300 |
Biomarker
|
disease |
CTD_human |
Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia.
|
17233643 |
2007 |
|
Amphetamine Abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia.
|
17233643 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.220 |
Biomarker
|
disease |
BEFREE |
β-arrestin-2 is involved in irisin induced glucose metabolism in type 2 diabetes via p38 MAPK signaling.
|
28888936 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.220 |
Therapeutic
|
disease |
RGD |
Effects of Chinese Fructus Mume formula and its separated prescription extract on insulin resistance in type 2 diabetic rats.
|
24337852 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.220 |
Biomarker
|
disease |
BEFREE |
Loss or dysfunction of beta-arrestin-2 results in deficiency of this signal complex and disturbance of insulin signalling in vivo, thereby contributing to the development of insulin resistance and progression of type 2 diabetes.
|
19122674 |
2009 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
RGD |
Overactivation of cannabinoid receptor type 1 in rostral ventrolateral medulla promotes cardiovascular responses in spontaneously hypertensive rats.
|
27861247 |
2017 |
|
Myocardial Reperfusion Injury
|
0.200 |
Biomarker
|
phenotype |
RGD |
β-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling.
|
29016703 |
2017 |
|
Portal Hypertension
|
0.200 |
Therapeutic
|
disease |
RGD |
Reactive oxygen species are involved in regulating hypocontractility of mesenteric artery to norepinephrine in cirrhotic rats with portal hypertension.
|
24719556 |
2014 |
|
Arteriovenous fistula
|
0.200 |
Biomarker
|
phenotype |
RGD |
Gender related alterations of β-adrenoceptor mechanisms in heart failure due to arteriovenous fistula.
|
22015551 |
2012 |
|
Graft Rejection
|
0.200 |
Biomarker
|
phenotype |
RGD |
Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys.
|
21193245 |
2011 |
|
Liver Neoplasms, Experimental
|
0.200 |
Biomarker
|
phenotype |
RGD |
Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats.
|
21167192 |
2011 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Overexpression of ARRB2 resulted in reduced tumor growth and increased response to Gemcitabine in tumor xenografts.
|
30787175 |
2019 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Experimentally, we show that knockout of ARRB2 decreases rate of RCC cell proliferation and migration in vitro and xenograft tumor growth in animals.
|
29559707 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
β-arrestin 2 has been reported to widely involve in multiple aspects of tumor development.
|
25973019 |
2015 |