ARRB2, arrestin beta 2, 409

N. diseases: 119; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 GeneticVariation disease BEFREE We therefore conducted a genetic case-control association analysis of the gene for ARRB2 with schizophrenia and METH use disorder in a Japanese population (547 people with schizophrenia, 177 with METH use disorder and 546 controls). 17233643 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 GeneticVariation disease BEFREE The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia. 19049562 2008
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.310 GeneticVariation disease BEFREE Association study of the β-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population. 22472784 2012
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement 		0.100 GeneticVariation phenotype GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.020 GeneticVariation group BEFREE Further studies are needed to determine whether variations in ARRB2 (or other MORIPs) are relevant to cocaine or opioid dependence in different ethnic populations or whether they confer a risk that is specific to dependence on other drugs of abuse. 22472784 2012
CUI: C0004610
Disease: Bacteremia
Bacteremia 		0.010 GeneticVariation disease BEFREE This study describes molecular mechanisms of antimicrobial resistance in an isolate from bacteraemia investigated through whole genome sequencing. bla<sub>NDM-7</sub> was found on IncA/C2 plasmid which also carried sul-1, aadA2, rmtC, bla<sub>CMY-6</sub> and ARR-2. ompK35 had mutations and changes from 39th amino acid. ompK36 was truncated to 248 amino acids.The isolate belonged to ST147. 31003835 2020
CUI: C0013384
Disease: Dyskinetic syndrome
Dyskinetic syndrome 		0.010 GeneticVariation disease LHGDN The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia. 19049562 2008
CUI: C0013404
Disease: Dyspnea
Dyspnea 		0.010 GeneticVariation phenotype BEFREE For univariate morphine associations, 1 variant on the 5-hydroxytryptamine type 3B (HTR3B) gene, and 4 on the β-2-arrestin gene (ARRB2) were associated with more intense breathlessness. 25948405 2015
CUI: C0028043
Disease: Nicotine Dependence
Nicotine Dependence 		0.010 GeneticVariation disease BEFREE In summary, our results provide the first evidence of a significant association for ARRB1 and ARRB2 variants with ND in an EA sample. 17579607 2008
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.010 GeneticVariation disease BEFREE The genetic variation of ARRB2 is associated with late-onset Alzheimer's disease in Han Chinese. 24635845 2014
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		0.010 GeneticVariation disease BEFREE Further studies are needed to determine whether variations in ARRB2 (or other MORIPs) are relevant to cocaine or opioid dependence in different ethnic populations or whether they confer a risk that is specific to dependence on other drugs of abuse. 22472784 2012
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.310 Biomarker group PSYGENET Deficient beta-arrestin-2-CRF(1) receptor interactions could contribute to the pathophysiology of affective disorders by inducing excessive CRF(1) receptor signaling. 17363685 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.310 Biomarker group BEFREE Deficient beta-arrestin-2-CRF(1) receptor interactions could contribute to the pathophysiology of affective disorders by inducing excessive CRF(1) receptor signaling. 17363685 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.300 Biomarker disease PSYGENET Here we show that lithium, a pharmacological agent used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling and related behaviors in mice by disrupting a signaling complex composed of Akt, beta-arrestin 2, and protein phosphatase 2A. 18191226 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.300 Biomarker disease PSYGENET Here we show that lithium, a pharmacological agent used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling and related behaviors in mice by disrupting a signaling complex composed of Akt, beta-arrestin 2, and protein phosphatase 2A. 18191226 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.300 Biomarker disease PSYGENET Here we show that lithium, a pharmacological agent used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling and related behaviors in mice by disrupting a signaling complex composed of Akt, beta-arrestin 2, and protein phosphatase 2A. 18191226 2008
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0236733
Disease: Amphetamine-Related Disorders
Amphetamine-Related Disorders 		0.300 Biomarker group CTD_human Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia. 17233643 2007
CUI: C0236804
Disease: Amphetamine Addiction
Amphetamine Addiction 		0.300 Biomarker disease CTD_human Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia. 17233643 2007
CUI: C0236807
Disease: Amphetamine Abuse
Amphetamine Abuse 		0.300 Biomarker disease CTD_human Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia. 17233643 2007
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.220 Biomarker disease BEFREE Loss or dysfunction of beta-arrestin-2 results in deficiency of this signal complex and disturbance of insulin signalling in vivo, thereby contributing to the development of insulin resistance and progression of type 2 diabetes. 19122674 2009
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.220 Biomarker disease BEFREE β-arrestin-2 is involved in irisin induced glucose metabolism in type 2 diabetes via p38 MAPK signaling. 28888936 2017
CUI: C0003855
Disease: Arteriovenous fistula
Arteriovenous fistula 		0.200 Biomarker phenotype RGD Gender related alterations of β-adrenoceptor mechanisms in heart failure due to arteriovenous fistula. 22015551 2012
CUI: C0018129
Disease: Graft Rejection
Graft Rejection 		0.200 Biomarker phenotype RGD Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys. 21193245 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.200 Biomarker group RGD Overactivation of cannabinoid receptor type 1 in rostral ventrolateral medulla promotes cardiovascular responses in spontaneously hypertensive rats. 27861247 2017