|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
We therefore conducted a genetic case-control association analysis of the gene for ARRB2 with schizophrenia and METH use disorder in a Japanese population (547 people with schizophrenia, 177 with METH use disorder and 546 controls).
|
17233643 |
2007 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia.
|
19049562 |
2008 |
|
Mood Disorders
|
0.310 |
Biomarker
|
group |
BEFREE |
Deficient beta-arrestin-2-CRF(1) receptor interactions could contribute to the pathophysiology of affective disorders by inducing excessive CRF(1) receptor signaling.
|
17363685 |
2007 |
|
Cocaine Dependence
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Association study of the β-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population.
|
22472784 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.220 |
Biomarker
|
disease |
BEFREE |
Loss or dysfunction of beta-arrestin-2 results in deficiency of this signal complex and disturbance of insulin signalling in vivo, thereby contributing to the development of insulin resistance and progression of type 2 diabetes.
|
19122674 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.220 |
Biomarker
|
disease |
BEFREE |
β-arrestin-2 is involved in irisin induced glucose metabolism in type 2 diabetes via p38 MAPK signaling.
|
28888936 |
2017 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
In vivo experiments showed that ADV.ARR(2)PB-iCasp9 induced apoptosis in LNCaP but not in HuH-7 xenograft tumors in an AP20187-dependent manner.Furthermore, a simple i.p. injection of AP20187 dramatically suppressed LNCaP tumor growth in nude mice and led to a significantly increased host survival.
|
11559553 |
2001 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Indeed, Arrb2 siRNAs decreased the expression of Wnt target genes in cells isolated from 12 of 18 tumors from Apc(Δ14/+) mice.
|
22315403 |
2012 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
We found that the xenograft tumor initiated earlier and grew more rapidly in beta-Arr1 transgenic mice than in both the beta-Arr2 transgenic and wild-type mice after inoculating murine liver cancer Hepa1-6 cells or lymphoma EL4 cells.
|
17890288 |
2008 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Overexpression of ARRB2 resulted in reduced tumor growth and increased response to Gemcitabine in tumor xenografts.
|
30787175 |
2019 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Experimentally, we show that knockout of ARRB2 decreases rate of RCC cell proliferation and migration in vitro and xenograft tumor growth in animals.
|
29559707 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
β-arrestin 2 has been reported to widely involve in multiple aspects of tumor development.
|
25973019 |
2015 |
|
Malignant neoplasm of prostate
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
To determine whether Cav-1 cooperates with c-Myc in development of premalignant lesions and prostate cancer in vivo, we generated transgenic mice with c-Myc overexpression driven by the ARR(2)PB promoter.
|
22144662 |
2012 |
|
Malignant neoplasm of prostate
|
0.040 |
Biomarker
|
disease |
BEFREE |
Collectively, these data provide evidence that Stat3 and Akt signaling cooperate in prostate cancer development and progression and that ARR(2)Pb.Stat3C x PTEN(+/-) mice represent a novel mouse model of prostate cancer to study these interactions.
|
21390188 |
2011 |
|
Malignant neoplasm of prostate
|
0.040 |
Biomarker
|
disease |
BEFREE |
The ARR(2) PB-PNP/Fludara system induced massive tumor cell death and a prolonged life span without systemic cytotoxicity; therefore, it might be a more attractive strategy for suicide gene therapy of prostate cancer.
|
22009763 |
2011 |
|
Malignant neoplasm of prostate
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We have recently developed a replication-deficient adenovirus carrying the human NIS cDNA linked to a composite probasin promoter, ARR(2)PB, aiming toward specific expression of the human NIS gene (h-NIS) in prostate tissue for targeted radioactive iodide therapy of prostate cancer (Ad-ARR(2)PB/hNIS).
|
14633711 |
2003 |
|
Prostate carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The ARR(2) PB-PNP/Fludara system induced massive tumor cell death and a prolonged life span without systemic cytotoxicity; therefore, it might be a more attractive strategy for suicide gene therapy of prostate cancer.
|
22009763 |
2011 |
|
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
To determine whether Cav-1 cooperates with c-Myc in development of premalignant lesions and prostate cancer in vivo, we generated transgenic mice with c-Myc overexpression driven by the ARR(2)PB promoter.
|
22144662 |
2012 |
|
Prostate carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Collectively, these data provide evidence that Stat3 and Akt signaling cooperate in prostate cancer development and progression and that ARR(2)Pb.Stat3C x PTEN(+/-) mice represent a novel mouse model of prostate cancer to study these interactions.
|
21390188 |
2011 |
|
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We have recently developed a replication-deficient adenovirus carrying the human NIS cDNA linked to a composite probasin promoter, ARR(2)PB, aiming toward specific expression of the human NIS gene (h-NIS) in prostate tissue for targeted radioactive iodide therapy of prostate cancer (Ad-ARR(2)PB/hNIS).
|
14633711 |
2003 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Emerging evidence indicates that β-arrestin 2, an important regulator of G protein coupled receptors, is involved in the pathogenesis of Alzheimer's disease (AD).
|
24635845 |
2014 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, these studies identify β-arrestin 2 as a new therapeutic target for reducing amyloid pathology and GPCR dysfunction in Alzheimer's disease.
|
23202293 |
2013 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Although expression of both ARRB1 and ARRB2 was reduced in serum from patients with AD, the levels of ARRB1 were much lower than those of ARRB2 in AD.
|
28611418 |
2017 |
|
Cerebrovascular accident
|
0.030 |
Biomarker
|
group |
BEFREE |
These results suggested that β-arrestin-2-MAPK-PDGF-β signaling enhanced protection of endothelial function and barrier integrity after stroke.
|
30718498 |
2019 |
|
Cerebrovascular accident
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Splenic ARRB2 expression was significantly increased after stroke and also showed a significant positive correlation with the sympathetic system activity.
|
29636059 |
2018 |