|
Bacteremia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study describes molecular mechanisms of antimicrobial resistance in an isolate from bacteraemia investigated through whole genome sequencing. bla<sub>NDM-7</sub> was found on IncA/C2 plasmid which also carried sul-1, aadA2, rmtC, bla<sub>CMY-6</sub> and ARR-2. ompK35 had mutations and changes from 39th amino acid. ompK36 was truncated to 248 amino acids.The isolate belonged to ST147.
|
31003835 |
2020 |
|
Encephalitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
β-Arrestin 2 protects against neurological function defects in HSV-1-induced encephalitis mice.
|
31469177 |
2020 |
|
Myocarditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The above results suggest that AVP induces IL-6 induction in murine hearts via the V<sub>1A</sub> receptor-mediated β-arrestin2/ERK<sub>1/2</sub>/NF-κB pathway, thus reveal a novel mechanism of myocardial inflammation in heart failure involving the V<sub>1A</sub>/β-arrestin 2/ERK<sub>1/2</sub>/NF-κB signaling pathway.
|
31515529 |
2020 |
|
Herpes encephalitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We explore the pathophysiological effect of Arrb2 in the brain using experimental HSE mice.
|
31469177 |
2020 |
|
Acute pancreatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
β-Arr1 but not β-arr2 is significantly downregulated in caerulein-induced AP in mice.
|
30144357 |
2019 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibitory effect of tanshinone IIA on inflammatory response in rheumatoid arthritis through regulating β-arrestin 2.
|
30988705 |
2019 |
|
Malignant neoplasm of endometrium
|
0.010 |
Biomarker
|
disease |
BEFREE |
β-arrestin-2 up-regulates toll-like receptor 2 signaling and inhibits apoptosis in human endometrial cancer heterotransplants in nude mice.
|
31675995 |
2019 |
|
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mice with selective deficiency of β-arrestin 2 in DCs developed severer experimental autoimmune encephalomyelitis with more DC infiltration in the CNS and increased IL-6 in serum.
|
30541881 |
2019 |
|
Hyperalgesia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Heroin-based crack induces hyperalgesia through β-arrestin 2 redistribution and phosphorylation of Erk1/2 and JNK in the periaqueductal gray area.
|
30641110 |
2019 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Our data support the novel concept that 'G protein-biased' β3-AR agonists that do not promote β3-AR/barr2 interactions may prove useful for the treatment of obesity and related metabolic disorders.
|
31270323 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In multivariate analysis only ARRB2 was an independent predictor of metastasis, disease-specific-mortality, and failure to Gemcitabine + Cisplatin (G+C) chemotherapy; ∼80% sensitivity and specificity to predict clinical outcome.
|
30787175 |
2019 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data support the novel concept that 'G protein-biased' β3-AR agonists that do not promote β3-AR/barr2 interactions may prove useful for the treatment of obesity and related metabolic disorders.
|
31270323 |
2019 |
|
Retinitis Pigmentosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
When transplanted subretinally into the Pde6brd1 mice, the CRX<sup>+</sup> cells settled next to the inner nuclear layer and made connections with the inner neurons of the host retina, and approximately one-third of them expressed the pan cone marker, Arrestin 3, indicating further maturation upon integration into the host retina.
|
30681766 |
2019 |
|
Sezary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of β-arrestin-2 gene and possible functional consequences on Sezary Syndrome.
|
31106661 |
2019 |
|
Endometrial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that Arr2 overexpression promoted the growth of human EC heterotransplants.
|
31675995 |
2019 |
|
Necrotizing Enterocolitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
β-arrestin-2 enhances intestinal epithelial apoptosis in necrotizing enterocolitis.
|
31612867 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
GPCR mediator β-arrestins (β-arr1 and β-arr2) regulate a variety of physiologic and pathologic processes, including hepatocellular carcinogenesis.
|
30216111 |
2019 |
|
airway disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Methods to Investigate the Roles for β-Arrestin-2 in Allergic Inflammatory Airway Disease.
|
30919364 |
2019 |
|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, β-arrestin-2 deficiency reversed the reduction of colocalization of phospho-ERK1/2 with phospho-cPLA<sub>2</sub>α in TLR4<sup>-/-</sup> mice following ischemic stroke.
|
30794438 |
2019 |
|
Necrotizing enterocolitis in fetus OR newborn
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study suggests that β-arrestin-2 induces NEC development by inhibiting BiP, thereby triggering apoptosis in response to endoplasmic reticulum stress.
|
31612867 |
2019 |
|
Aortic Valve Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
MAPK kinase family, β-arrestin-2, Akt, and Ca<sup>2+</sup>-related signaling pathways were markedly activated in TAC but mildly upregulated or unchanged in AR.
|
29196344 |
2018 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings point to a proinflammatory role for β-arr2-dependent signaling and support β-arr2 as a novel therapeutic target in asthma.
|
29361236 |
2018 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Experimentally, we show that knockout of ARRB2 decreases rate of RCC cell proliferation and migration in vitro and xenograft tumor growth in animals.
|
29559707 |
2018 |
|
Squamous cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We performed IHC on tissue microarrays from two cohorts of lung cancer patients to analyse the expression of beta-arrestin-1, beta-arrestin-2 and clinically used diagnostic markers in ADC and SCC samples.
|
30078843 |
2018 |
|
Coronary Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Apparently, β-arr2 is important on CPC survival by means of mobility and tube formation in myocardial ischemia.
|
29625512 |
2018 |