MMP3, matrix metallopeptidase 3, 4314

N. diseases: 473; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.010 Biomarker phenotype BEFREE Recent studies have demonstrated that matrix metalloproteinase 3 (MMP3) is a key event in associative memory formation, learning and synaptic plasticity, which are important in psychiatric disorders. 19245826 2009
CUI: C0022602
Disease: Actinic keratosis
Actinic keratosis 		0.010 AlteredExpression disease BEFREE MMP-2 and MMP-3 mRNAs were detected in SCC but not in AK. 10362121 1999
CUI: C0241868
Disease: acute aortic dissection
acute aortic dissection 		0.010 AlteredExpression disease BEFREE Pooled analyses demonstrated no significant differences in MMP-1 (4 studies; P = 0.21), MMP-2 (5 studies; P = 0.62) and MMP-3 levels (2 studies; P = 0.94) between AAD patients and control subjects; and significantly higher MMP-8 (2 studies; SMD 2.11; P = 0.020), MMP-9 (9 studies; SMD 1.54; P < 0.001) and MMP-12 levels (2 studies; SMD 1.33; P < 0.001) in AAD patients than in control subjects. 31808522 2020
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.020 GeneticVariation disease BEFREE Because of linkage disequilibrium, MMP1 and MMP3 polymorphisms were combined on chromosome 11q22.3, and the 5A-1171-G-519 haplotype had a genetic risk factor for ACS (OR=1.505, 95% CI=1.219-1.857, P=0.00013), whereas the 6A-1171-G-519 haplotype had a decreased risk of ACS (OR=0.815, 95% CI=0.677-0.981, P=0.03). 23377317 2013
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.020 GeneticVariation disease BEFREE The aim of this study was to examine the association between MMP1-1607dupG (rs1799750) and MMP3-1171dupA (rs3025058) gene polymorphisms and acute coronary syndromes (ACS) in the form of unstable angina. 29044936 2017
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.030 GeneticVariation disease BEFREE The aim of this study was to examine the association between MMP1-1607dupG (rs1799750) and MMP3-1171dupA (rs3025058) gene polymorphisms and acute coronary syndromes (ACS) in the form of unstable angina. 29044936 2017
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.030 GeneticVariation disease BEFREE In conclusion, the MMP-3 5A/6A polymorphism is significantly associated with the occurrence of acute coronary syndrome, MMP-3 activity, and severity of coronary atherosclerosis. 17027562 2006
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.030 GeneticVariation disease BEFREE Within this context, our aim was to examine whether MMP1, MMP3, and MMP9 gene polymorphisms are associated with susceptibility to acute coronary syndrome (ACS) or angiographic coronary artery disease (CAD). 23377317 2013
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.070 GeneticVariation disease BEFREE We can conclude that there was a significant association between the 5A/6A polymorphism in the promoter region of stromelysin-1 gene and young MI in Taiwan. 12876636 2003
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.070 GeneticVariation disease BEFREE The 5A allele of the MMP3 5A/6A polymorphism was associated with acute myocardial infarction (odds ratio (OR) 1.26, 95% confidence interval (CI) 1.1 to 1.4, p<0.001), suggesting its role in plaque rupture. 16905683 2006
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.070 Biomarker disease BEFREE Matrix metalloproteinases, such as stromelysin-1, are implicated in the pathogenesis of coronary artery disease (CAD) and acute myocardial infarction (MI). 12515907 2002
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.070 AlteredExpression disease BEFREE Also, MMP-3 levels in patients with AMI carrying 5A/5A were elevated compared with those carrying 6A/6A. 26712881 2016
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.070 GeneticVariation disease BEFREE There are significant differences in MMP-3 '5A' allele and genotype in the patients with AMI comparing with controls. 20616708 2010
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.070 GeneticVariation disease BEFREE Moreover, The 5A/6A polymorphism in the promoter region of the stromelysin-1 gene may be a pathogenetic risk factor for acute myocardial infarction. 12205736 2002
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.070 Biomarker disease BEFREE Together with previous findings, these results primarily implicate MMP-3 in atherosclerosis progression rather than in acute MI. 16629857 2006
CUI: C0001342
Disease: Acute periodontitis
Acute periodontitis 		0.010 GeneticVariation disease BEFREE Moreover, MMP3 rs35068180 polymorphism might be associated with a lower risk of aggressive periodontitis (AgP) in Asians (allelic genetic model: OR = 0.66, 95% CI: 0.48-0.91, P(heterogeneity) = 0.945), and CP in Caucasians and Brazilians. 26123623 2015
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.020 Biomarker group BEFREE Tissue samples were also examined for the expression of type-I collagenase (9 adenocarcinomas and 4 normal) and stromelysin I (13 adenocarcinomas) by northern analysis. 1848860 1991
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.020 GeneticVariation group BEFREE The functional SNP in the matrix metalloproteinase-3 promoter modifies susceptibility and lymphatic metastasis in esophageal squamous cell carcinoma but not in gastric cardiac adenocarcinoma. 15319302 2004
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.010 AlteredExpression disease BEFREE We examined gene expression signatures of colon adenocarcinoma cell lines with different metastatic potentials and found that rapidly metastatic cells powerfully expressed genes encoding MMP3 and MMP9. 29761931 2018
CUI: C0279628
Disease: Adenocarcinoma Of Esophagus
Adenocarcinoma Of Esophagus 		0.010 GeneticVariation disease BEFREE Two MMP haplotypes [MMP1-MMP3-MMP12 (-82) 2G-5A-A (adjusted odds ratio 1.36, 95% confidence interval 1.0-1.8; P = 0.03) and 2G-5A-G (adjusted odds ratio 1.70, 95% confidence interval 1.1-2.6; P = 0.01)] were also associated with increased EA risk. 19321798 2009
CUI: C0007112
Disease: Adenocarcinoma of prostate
Adenocarcinoma of prostate 		0.010 Biomarker disease BEFREE Additional northern blot analysis was performed using probes to human type-IV collagenase, type-I collagenase and stromelysin I in human prostate adenocarcinoma as well as normal prostate tissue. 1848860 1991
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 GeneticVariation group LHGDN Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma. 17125518 2006
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.010 GeneticVariation disease BEFREE Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma. 17125518 2006
CUI: C0032580
Disease: Adenomatous Polyposis Coli
Adenomatous Polyposis Coli 		0.010 Biomarker disease BEFREE Pro-MMP1 protein predominated over MMP3 in FAP-associated cell culture supernatants, while MMP3 was the dominant antigen in sporadic tumor cell supernatants. 19728161 2009
CUI: C0410702
Disease: Adolescent idiopathic scoliosis
Adolescent idiopathic scoliosis 		0.030 GeneticVariation disease BEFREE Lack of association between the promoter polymorphisms of MMP-3 and IL-6 genes and adolescent idiopathic scoliosis: a case-control study in a Chinese Han population. 20436380 2010