MMP3, matrix metallopeptidase 3, 4314

N. diseases: 473; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.400 Biomarker disease CTD_human
CUI: C0410606
Disease: Cervical Disc Degenerative Disorder
Cervical Disc Degenerative Disorder 		0.200 Therapeutic disease RGD "Herb formula ""Fufangqishe-Pill"" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats." 20472983 2010
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.250 Biomarker disease BEFREE <b>Results:</b> The results of ELISA (IL-1β and tumor necrosis factor-α), the histological evaluation (Mankin and OARSI score), western blotting [COL2A1, matrix metalloproteinase (MMP)-3, MMP-13, IL-1β, and nuclear factor-kappaB (NF-κB) p65], and immunohistochemistry (COL2A1, MMP-3, and MMP-13) indicated that oral CAR attenuated the development of T2DM-induced OA and suppressed the inflammatory response. 29928231 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 Biomarker disease BEFREE <b>Results:</b> The results of ELISA (IL-1β and tumor necrosis factor-α), the histological evaluation (Mankin and OARSI score), western blotting [COL2A1, matrix metalloproteinase (MMP)-3, MMP-13, IL-1β, and nuclear factor-kappaB (NF-κB) p65], and immunohistochemistry (COL2A1, MMP-3, and MMP-13) indicated that oral CAR attenuated the development of T2DM-induced OA and suppressed the inflammatory response. 29928231 2018
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.100 AlteredExpression disease BEFREE <b>Results:</b> There were no significant differences between two groups in baseline conventional RA disease activity markers such as RF, erythrocyte sedimentation rate, CRP, and matrix metalloproteinase-3. 31422723 2019
CUI: C0263912
Disease: Rotator cuff syndrome
Rotator cuff syndrome 		0.020 Biomarker disease BEFREE (2) Are there haplotypes of MMP-1 and MMP-3 correlated with rotator cuff tears? 28160256 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE 013); and high tumor cell expression of MMP-3 (P =.077), MMP-11 (P =.031), and MMP-14 (P =.019). 10561218 1999
CUI: C0149871
Disease: Deep Vein Thrombosis
Deep Vein Thrombosis 		0.010 AlteredExpression disease BEFREE 18.18 ± 9.03, P < 0.05).Serum MMP3 level in DVT patients carrying 5A/6A and 6A/6A genotypes was higher than the control group (P < 0.05). 27177702 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.070 GeneticVariation group BEFREE 5A5A and 5A6A genotypes of MMP-3 (odds ratio (OR) 1.5; P = 0.021), II and ID genotypes of ACE (OR 1.7; P = 0.006) along with traditional ischaemic heart disease risk factors such as smoking (OR 4.9; P = 0.001), hypertension (OR 2.0; P = 0.001), diabetes mellitus (OR 2.9; P = 0.001) and dyslipidaemia (OR 2.1; P = 0.001) increased the risk of STEMI. 29141503 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.040 GeneticVariation group BEFREE 5A5A and 5A6A genotypes of MMP-3 (odds ratio (OR) 1.5; P = 0.021), II and ID genotypes of ACE (OR 1.7; P = 0.006) along with traditional ischaemic heart disease risk factors such as smoking (OR 4.9; P = 0.001), hypertension (OR 2.0; P = 0.001), diabetes mellitus (OR 2.9; P = 0.001) and dyslipidaemia (OR 2.1; P = 0.001) increased the risk of STEMI. 29141503 2018
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias 		0.010 GeneticVariation group BEFREE 5A5A and 5A6A genotypes of MMP-3 (odds ratio (OR) 1.5; P = 0.021), II and ID genotypes of ACE (OR 1.7; P = 0.006) along with traditional ischaemic heart disease risk factors such as smoking (OR 4.9; P = 0.001), hypertension (OR 2.0; P = 0.001), diabetes mellitus (OR 2.9; P = 0.001) and dyslipidaemia (OR 2.1; P = 0.001) increased the risk of STEMI. 29141503 2018
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.300 AlteredExpression disease BEFREE AAA wall expressed significantly more stromelysin-1 (MMP-3) (mean log(10) ratio [copy enzyme cDNA/copy GAPDH cDNA], -1.9; range, -3.3 to -0.7) than the AOD wall (mean, 4; range, -5.7 to -2.4), P<0.005. 11815431 2002
CUI: C0003486
Disease: Aortic Aneurysm
Aortic Aneurysm 		0.030 AlteredExpression disease BEFREE AAA wall expressed significantly more stromelysin-1 (MMP-3) (mean log(10) ratio [copy enzyme cDNA/copy GAPDH cDNA], -1.9; range, -3.3 to -0.7) than the AOD wall (mean, 4; range, -5.7 to -2.4), P<0.005. 11815431 2002
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.030 AlteredExpression disease LHGDN Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3. 15763339 2005
CUI: C0155094
Disease: Corneal pannus
Corneal pannus 		0.020 AlteredExpression disease BEFREE Pannus-like tissue and the plica express IL-1β and MMP-3. 21371079 2011
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease 		0.020 Biomarker disease BEFREE LDD is closely associated in occurrence and severity with occupational, environmental risk factors and susceptibility genes namely MMP-3, and VDR (ApaI). 23975061 2014
CUI: C0391826
Disease: Lhermitte-Duclos disease
Lhermitte-Duclos disease 		0.020 Biomarker disease BEFREE LDD is closely associated in occurrence and severity with occupational, environmental risk factors and susceptibility genes namely MMP-3, and VDR (ApaI). 23975061 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Tumor lnc-MMP3-1 levels were closely associated with differentiation degree (P = 0.016), tumor invasion (P = 0.015) and TNM stage (P = 0.015). 28960885 2017
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.100 AlteredExpression disease BEFREE MMP-3 mRNA expression by the PBMC of NAT-RA patients was statistically different to that in ENT-RA patients. 10544841 1999
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.040 AlteredExpression disease BEFREE Stromelysin-1, though strongly expressed in cell lines, does not appear to play a role in glioblastoma tumors in vivo. 10571406 1999
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.030 AlteredExpression disease BEFREE Stromelysin-1, though strongly expressed in cell lines, does not appear to play a role in glioblastoma tumors in vivo. 10571406 1999
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.030 AlteredExpression disease BEFREE Stromelysin-1, though strongly expressed in cell lines, does not appear to play a role in glioblastoma tumors in vivo. 10571406 1999
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.030 AlteredExpression disease BEFREE Stromelysin-1, though strongly expressed in cell lines, does not appear to play a role in glioblastoma tumors in vivo. 10571406 1999
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.040 AlteredExpression group BEFREE Stromelysin-1 is markedly overexpressed at inflamed sites in patients with IBD whereas TIMP-1 remains unaltered. 10861265 2000
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 GeneticVariation disease BEFREE Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis. 11116068 2000