|
Secondary malignant neoplasm of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Clinical osteoblastic bone metastasis samples had higher levels of Notch3 and MMP-3 compared with patient matched visceral metastases or osteolytic metastasis samples.
|
31467432 |
2020 |
|
acute aortic dissection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Pooled analyses demonstrated no significant differences in MMP-1 (4 studies; P = 0.21), MMP-2 (5 studies; P = 0.62) and MMP-3 levels (2 studies; P = 0.94) between AAD patients and control subjects; and significantly higher MMP-8 (2 studies; SMD 2.11; P = 0.020), MMP-9 (9 studies; SMD 1.54; P < 0.001) and MMP-12 levels (2 studies; SMD 1.33; P < 0.001) in AAD patients than in control subjects.
|
31808522 |
2020 |
|
Chronic graft-versus-host disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis focused on previously identified cGVHD cellular biomarkers, including naive helper T (Th) cells, recent thymic emigrant (RTE) Th cells, CD21<sup>low</sup> B cells, CD56<sup>bright</sup> NK<sub>reg</sub> cells, and T<sub>reg</sub> cells ST2, osteopontin, sBAFF, sCD25, TIM-3, matrix metallopeptidase 3, ICAM-1, CXCL10, and soluble aminopeptidase N. The ATG-treated group had a >10-fold decrease in both RTE naive Th and naive Th cells (P < .0001) and a 10-fold increase in CD56<sup>bright</sup> NK<sub>reg</sub> cells (P < .0001).
|
31756535 |
2020 |
|
Metastatic Malignant Neoplasm in the Viscera
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Clinical osteoblastic bone metastasis samples had higher levels of Notch3 and MMP-3 compared with patient matched visceral metastases or osteolytic metastasis samples.
|
31467432 |
2020 |
|
Aortic Valve Stenosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Measures of AS severity were associated with the primary outcome in both sexes, whereas N-terminal pro-B-type natriuretic peptide, MMP-3, and mass/volume were only associated in men.
|
29248646 |
2019 |
|
Dejerine-Sottas Disease (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
The arthritis/DSS-treated mice did not demonstrate changes in hind foot volumes or in the concentration of matrix metalloproteinase-3 (MMP-3) in the plasma; however, plasma levels of interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α were increased.
|
31366877 |
2019 |
|
Encephalitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The patients with encephalitis had the most significantly increased levels of MMPs in CSF, and MMP-3, MMP-8, and MMP-12 were exclusively increased in this group, whereas MMP-9 in CSF was increased in the patients with VZV meningitis.
|
30777092 |
2019 |
|
Encephalitis, St. Louis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We observed significantly higher MMP-3 levels in SLE patients compared to healthy controls (<i>P</i> < 0.001, Hedges' <i>g</i>: 2.104, 95% CI 1.426-2.782).
|
31396295 |
2019 |
|
Peptic Esophagitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Treatment of RE rats with isorhamnetin improved esophageal barrier function, through upregulating proteins expression of occludin and zonula occludens-1 (ZO-1) and downregulating proteins expression of matrix matalloproteinases-3 (MMP3) and -9.
|
31586635 |
2019 |
|
External exotoses
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mice fed 4-MU exhibited lower OARSI scores after DMM; reduced osteophyte formation and reduced MMP3 and MMP13 immunostaining.
|
31774188 |
2019 |
|
Sensorineural Hearing Loss (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
The presence of sensorineural hearing loss was related to matrix metalloproteinase-3 (MMP-3).
|
30893257 |
2019 |
|
Keratoconus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, reduced expression of MMP3 was detected in keratoconus patients.
|
31022731 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We observed significantly higher MMP-3 levels in SLE patients compared to healthy controls (<i>P</i> < 0.001, Hedges' <i>g</i>: 2.104, 95% CI 1.426-2.782).
|
31396295 |
2019 |
|
Lupus Nephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found increased MMP-1, MMP-2, and MMP-3 expression in LN glomeruli and a significant correlation with the activity features, with higher activity index score and worse renal function (p < .001).
|
30973283 |
2019 |
|
Meningitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Encephalitis and meningitis patients differed with respect to other chemokines (CXCL11) and MMPs (MMP-3, MMP-8, MMP-9, and MMP-12), indicating that different location of the virus gives rise to qualitative differences in the ensuing inflammatory response.
|
30777092 |
2019 |
|
polyps
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Interleukin 1 beta and Matrix Metallopeptidase 3 Contribute to Development of Epidermal Growth Factor Receptor-Dependent Serrated Polyps in Mouse Cecum.
|
31470007 |
2019 |
|
Anaplastic thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, we identified a specific molecular mechanisms for the development of ATC by integrated analysis of transcriptome and in vitro experiments, which suggested that MMP3 and MMP13 might be developed as novel therapeutic targets for ATC.
|
31081124 |
2019 |
|
Viral myocarditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, Ginkgo biloba extract may be a promising therapeutic approach against VMC because it improved myocardial injury and alleviated the degree of myocardial fibrosis through suppression of S100A4 and MMP-3.
|
31359441 |
2019 |
|
Autoimmune skin disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MMP3 levels in healthy controls and autoimmune skin disease patients were comparable with either pre-transplant or no-rejection/NSR episodes of VCA patients.
|
31849957 |
2019 |
|
Gastro-esophageal reflux disease with esophagitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Treatment of RE rats with isorhamnetin improved esophageal barrier function, through upregulating proteins expression of occludin and zonula occludens-1 (ZO-1) and downregulating proteins expression of matrix matalloproteinases-3 (MMP3) and -9.
|
31586635 |
2019 |
|
androgen independent prostate cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Combined RNAseq and ChIP-seq revealed that NO66 activates the survival gene MCL1, the invasion-associated genes IGFBP5 and MMP3, the pro-oncogenic genes CTNNB1 and CCND1, and the epigenetic modifier gene KMT2A in androgen-independent PCa.
|
30858546 |
2019 |
|
DOSAGE-SENSITIVE SEX REVERSAL
|
0.010 |
Biomarker
|
disease |
BEFREE |
The arthritis/DSS-treated mice did not demonstrate changes in hind foot volumes or in the concentration of matrix metalloproteinase-3 (MMP-3) in the plasma; however, plasma levels of interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α were increased.
|
31366877 |
2019 |
|
Osteophyte
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mice fed 4-MU exhibited lower OARSI scores after DMM; reduced osteophyte formation and reduced MMP3 and MMP13 immunostaining.
|
31774188 |
2019 |
|
Serrated polyp
|
0.010 |
Biomarker
|
disease |
BEFREE |
MMP3 produced by PDGFRA<sup>+</sup> fibroblasts is important for serrated polyp development.
|
31470007 |
2019 |
|
Anaplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we found that fermentation supernatant (FS) of S. aureus accelerated dedifferentiation of chondrocytes and induced expression of catabolic factors including A Disintegrin-like and Metalloproteinase with Thrombospondin-1 motifs 5, NO synthase 2, matrix metalloproteinase-3, -13.
|
28513981 |
2018 |