|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia.
|
17074966 |
2007 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results confirm association of BD and schizophrenia with the 1p36.3 MTHFR locus and with the methyl group transfer using folate-dependent one-carbon pathway.
|
17188847 |
2007 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study examined whether schizophrenia patients homozygous for the risk allele (T/T) exhibit greater impairment in executive function, and determined the extent to which MTHFR's effects on negative symptoms underlie this relationship.
|
17344026 |
2007 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
This study examined whether schizophrenia patients homozygous for the risk allele (T/T) exhibit greater impairment in executive function, and determined the extent to which MTHFR's effects on negative symptoms underlie this relationship.
|
17344026 |
2007 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data provided no evidence that transmission of the MTHFR 677T allele is associated with schizophrenia risk.
|
17503473 |
2007 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Increased MTHFR 677T allele load confers risk for negative symptoms in schizophrenia, while reducing severity of positive symptoms.
|
17543893 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Increased MTHFR 677T allele load confers risk for negative symptoms in schizophrenia, while reducing severity of positive symptoms.
|
17543893 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Our findings do not support a major role for the COMT 324AA and MTHFR 677TT genotype alone, but the combination of both genotypes might increase schizophrenia susceptibility.
|
17716874 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings do not support a major role for the COMT 324AA and MTHFR 677TT genotype alone, but the combination of both genotypes might increase schizophrenia susceptibility.
|
17716874 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder.
|
18165967 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder.
|
18165967 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two common, functional polymorphisms, catechol-O-methyltransferase (COMT) Val108/158Met and methylenetetrahydrofolate reductase (MTHFR) C677T, have separately been associated with executive function performance in schizophrenia.
|
18186041 |
2008 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
CTD_human |
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
|
18583979 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A second polymorphism, methylenetetrahydrofolate reductase (MTHFR) 677C --> T (rs1801133), has been associated with overall schizophrenia risk and executive function impairment in patients, and may influence dopamine signaling through mechanisms upstream of COMT effects.
|
18988738 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
These findings are consistent with epistatic effects of the COMT and MTHFR polymorphisms on prefrontal dopamine signaling, and suggest that in schizophrenia patients, the MTHFR 677T allele exacerbates prefrontal dopamine deficiency.
|
18988738 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, both elevated plasma homocysteine levels and variation in the MTHFR 677C-->T gene are related to increased rates of schizophrenia and are risk factors for schizophrenia.
|
19564051 |
2009 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among the Scandinavian patients the functional MTHFR SNP rs1801133 (C677T) significantly affected age at onset of schizophrenia in a dose-dependent manner (P = 0.0015), with lower age of onset with increasing numbers of the mutant T-allele.
|
19746410 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia.
|
19939410 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that deficient MTHFR enzyme activity in pregnant women, related to the A1298C variant, is associated with a higher risk of having offspring affected with schizophrenia.
|
20044984 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Overall, this study found no support that maternal/child MTHFR C677T genotype and maternal folate intake during pregnancy contribute to common aetiological pathways that are shared between schizophrenia and non-clinical psychotic symptoms in adolescents, assuming that decreased folate-status increases schizophrenia risk.
|
20418067 |
2010 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
These data provide evidence supporting an association between MTHFR and risk of metabolic syndrome in patients with schizophrenia.
|
20547447 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data.
|
20692813 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Further evidence that methylenetetrahydrofolate reductase A1298C polymorphism is a risk factor for schizophrenia.
|
20694488 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, neither winter birth nor MTHFR genotype were significantly associated with increased schizophrenia risk.
|
21093223 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?
|
21185933 |
2011 |