|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Conflicting evidence has been found for the association between polymorphisms of the NPY gene and obesity in humans.
|
21937627 |
2011 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Data were extracted and summary estimates of the association between the NPY variants and obesity were examined.
|
26240981 |
2015 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the role of two functional NPY polymorphisms, NPY-Leu7Pro (rs16139) and NPY-399C/T (rs16147) and obesity for the development of asthma as well as atherosclerosis in asthmatic and non-asthmatic subjects.
|
23122776 |
2012 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis did not reveal significant association with obesity and NPY single-nucleotide polymorphisms (SNPs) in the present study.
|
20531438 |
2010 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Neuropeptide Y polymorphism significantly magnifies diabetes and cardiovascular disease risk in obesity: the Hoorn Study.
|
18043699 |
2009 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The objective was to examine the effects of NPY variant rs16147 on central obesity and abdominal fat distribution in response to dietary interventions.
|
26156739 |
2015 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
One of these, a cytosine to thymine (C-->T) substitution in the untranslated region between the genes for NPY Y1 and Y5 (allele frequency 0.11), was significantly associated with both lower fasting triglyceride level (152 vs 125 mg/dl), and higher high-density lipoprotein (HDL) concentrations (49 vs 45 mg/dl) (p < 0.01) in 306 obese subjects.
|
12220433 |
2002 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In obese males, the rs164147 polymorphism of the NPY gene is associated with leptin, insulin level, HOMA-IR, and an increased risk of MetS and its related phenotypes, such as central obesity and hyperglycemia.
|
27788523 |
2016 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Because NPY is a potent orexigenic peptide stimulating food intake, and genetic variation of the gene has been shown to influence development of obesity, we investigated the impact of NPY polymorphisms on antipsychotic-induced BWG.We analyzed 5 polymorphisms in the NPY gene (rs10551063, rs16147, rs5573, rs5574, and rs16475) in schizophrenia subjects (n = 226), treated mostly with clozapine and olanzapine for up to 14 weeks.
|
23277265 |
2013 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Sequence variation within the neuropeptide Y gene and obesity in Mexican Americans.
|
10832764 |
2000 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The consistent findings among men suggest that the NPY Leu7Pro polymorphism (or another linked marker) might be involved in the development of obesity at younger ages.
|
16568137 |
2006 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
No significant interaction between NPY SNP polymorphisms and obesity were detected.
|
27469060 |
2016 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The role of NPY in metabolic homeostasis: implications for obesity therapy.
|
11060746 |
2000 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Together, these results indicate that DMH NPY plays an important role in modulating food intake and energy balance and its dysregulation causes disordered energy balance leading to obesity.
|
19129396 |
2009 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
These data illustrate that mild cold stress is a critical factor preventing the development of obesity in Snord116<sup>-/-</sup> mice via the NPY system.
|
27823858 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Centrally administered NPY causes robust increases in food intake and body weight and, with chronic administration, can eventually produce obesity.
|
17785427 |
2007 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our results provide evidence that the functionally relevant SNP in the NP-Y promoter gene affects body fat distribution and serum leptin levels in women, pointing towards possible behavioral effects of NPY in obesity.
|
23652383 |
2013 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The neuropeptide Y (NPY) Y<sub>4</sub> receptor (Y<sub>4</sub>R) is involved in energy homeostasis and considered a potential drug target for the treatment of obesity.
|
28345900 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The neuropeptide Y system has proven to be one of the most important regulators of feeding behaviour and energy homeostasis, thus presenting great potential as a therapeutic target for the treatment of disorders such as obesity and at the other extreme, anorexia.
|
21545413 |
2011 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Loss of neuropeptide Y (NPY) can correct the obesity syndrome of mutant mice lacking of leptin (ob/ob).
|
28864114 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
These various effects plus a number of others make NPY an attractive target for the potential treatment of human diseases, such as obesity, metabolic disorders, hypertension and heart failure.
|
12678499 |
2003 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
As NPY and NPY2R are interesting candidate genes for obesity, we hypothesized that a genetic variation in these genes might be implicated in the pathogenesis of obesity.
|
28857123 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, long-term interference with the NPY system to target obesity or cancer related aspects needs to consider potential side effects on bone health.
|
21439311 |
2011 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The objective of the present study was to evaluate the association of single nucleotide polymorphisms (SNPs) in the NPY gene with obesity, metabolic syndrome features, and inflammatory and cardiovascular disease (CVD) risk biomarkers in Spanish children.
|
23624317 |
2013 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Reduced dopaminergic neurotransmission in the suprachiasmatic nucleus of seasonally obese animals appears to drive noradrenalin and NPY mediated transmissions in other nuclei to induce the obesity syndrome at the appropriate time of year.
|
14623356 |
2003 |