|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The present study examined the neuropeptide-Y Y1 receptor gene (NPYY1R) for involvement in essential hypertension (HT) and obesity.
|
7902088 |
1993 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Ultimately, characterization of the specific "feeding' receptors which mediate NPY's central effects on energy homeostasis may provide opportunities for designing drugs to manipulate and appetite and energy balance in man, notably obesity and the cachexia commonly associated with malignancy and chronic infection.
|
8871182 |
1996 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Two complementary genetic approaches were used: 1) linkage analyses between obesity and polymorphic markers located nearby NPY and rNPY-Y1/-Y5 genes (respectively on chromosomes 7p15.1 and 4q[31.3-32]) in 93 French Caucasian morbidly obese families; 2) single strand conformation polymorphism (SSCP) scanning of the coding region of the NPY and rNPY-Y1 genes performed in 50 unrelated obese patients ascertained on the basis of a body mass index of 27 kg/m2 or more and a family history of obesity.
|
9222646 |
1997 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
NPY deficiency attenuates the obesity syndrome of mice deficient for leptin (ob/ob), but these effects are not mediated by NPY signaling through the Y5R because Y5R-null ob/ob mice are equally obese.
|
9623983 |
1998 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Significant linkage (P = 0.042) was found between obesity and NPY within the obese sibling pairs.
|
10207720 |
1999 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The role of NPY in metabolic homeostasis: implications for obesity therapy.
|
11060746 |
2000 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Sequence variation within the neuropeptide Y gene and obesity in Mexican Americans.
|
10832764 |
2000 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
To determine the possibility of the disturbance in neuropeptides in human obesity and their consequent changes in response to negative energy balance, we evaluated plasma and cerebrospinal fluid (CSF) leptin, NPY, and alpha-MSH levels in obese women before and after weight loss in comparison with normal control women.
|
11600552 |
2001 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Modest overexpression of neuropeptide Y in the brain leads to obesity after high-sucrose feeding.
|
11334428 |
2001 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
One of these, a cytosine to thymine (C-->T) substitution in the untranslated region between the genes for NPY Y1 and Y5 (allele frequency 0.11), was significantly associated with both lower fasting triglyceride level (152 vs 125 mg/dl), and higher high-density lipoprotein (HDL) concentrations (49 vs 45 mg/dl) (p < 0.01) in 306 obese subjects.
|
12220433 |
2002 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The regulation of NPY/NPY-R expression and function appears to be part of a complex system controlling multiple physiological functions, and its disruption might be relevant in the pathophysiology of disease states such as obesity.
|
12570784 |
2003 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
These various effects plus a number of others make NPY an attractive target for the potential treatment of human diseases, such as obesity, metabolic disorders, hypertension and heart failure.
|
12678499 |
2003 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Reduced dopaminergic neurotransmission in the suprachiasmatic nucleus of seasonally obese animals appears to drive noradrenalin and NPY mediated transmissions in other nuclei to induce the obesity syndrome at the appropriate time of year.
|
14623356 |
2003 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in the ghrelin (GHRL) and neuropeptide Y (NPY) genes were examined in the same population-based case-control study of NHL to further explore the role of genes involved in energy homeostasis and obesity in susceptibility to NHL.
|
15894681 |
2005 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Ghrelin and NPY mRNA levels followed the same trend and were significantly higher in the hypothalamus in obese compared to lean subjects, suggesting a central origin for the increased protein content in the obese subjects.
|
16957407 |
2006 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The consistent findings among men suggest that the NPY Leu7Pro polymorphism (or another linked marker) might be involved in the development of obesity at younger ages.
|
16568137 |
2006 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Centrally administered NPY causes robust increases in food intake and body weight and, with chronic administration, can eventually produce obesity.
|
17785427 |
2007 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
RGD |
Difference of NPY and its receptor gene expressions between obesity and obesity-resistant rats in response to high-fat diet.
|
17447163 |
2007 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our findings show that life-long tonic repression of NPY system with a stable increase in leptin availability in the hypothalamus prevented the age-related and high fat-diet-induced obesity, hyperinsulinemia and diabetes and extended lifespan.
|
17979776 |
2007 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Together, these results indicate that DMH NPY plays an important role in modulating food intake and energy balance and its dysregulation causes disordered energy balance leading to obesity.
|
19129396 |
2009 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Neuropeptide Y polymorphism significantly magnifies diabetes and cardiovascular disease risk in obesity: the Hoorn Study.
|
18043699 |
2009 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis did not reveal significant association with obesity and NPY single-nucleotide polymorphisms (SNPs) in the present study.
|
20531438 |
2010 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Recent research demonstrates that stress, acting through the neuropeptide Y (NPY) and glucocorticoid systems, potentiates the development of obesity and other aspects of metabolic syndrome in mice fed a high caloric, fat and sugar diet.
|
20881319 |
2010 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Conflicting evidence has been found for the association between polymorphisms of the NPY gene and obesity in humans.
|
21937627 |
2011 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The neuropeptide Y system has proven to be one of the most important regulators of feeding behaviour and energy homeostasis, thus presenting great potential as a therapeutic target for the treatment of disorders such as obesity and at the other extreme, anorexia.
|
21545413 |
2011 |